Results 11 to 20 of about 4,269 (166)
Digit ratio as an endophenotype in a schizophrenia population
South African Journal of Psychiatry, 2021 Background: Schizophrenia is a debilitating mental health condition affecting the lives of many South Africans. The origins of the heterogeneity in the presentation of the illness remain uncertain.
Wilhelm D.B. Nieuwoudt +4 more
doaj +1 more source
TULP4, a novel E3 ligase gene, participates in neuronal migration as a candidate in schizophrenia
CNS Neuroscience &Therapeutics, EarlyView., 2023 Mutations identified from four SCZ pedigrees resulted in decreased TULP4 expression. Tulp4 knockdown caused delayed neuron migration in embryonic mice, and impaired cognition and prepulse inhibition in adult mice. These phenotypes may be related to TULP4 through its involvement in the formation of a novel E3 ubiquitin ligases.
Yan Bi +19 more
wiley +1 more source
Neuromodulation: Technology at the Neural Interface, EarlyView., 2021 Abstract Introduction Deep brain stimulation (DBS) is an effective treatment for refractory obsessive–compulsive disorder (OCD). Neuropsychological assessment contributes to DBS treatment in several ways: it monitors the cognitive safety of the treatment, identifies beneficial or detrimental cognitive side effects and it could aid to explain ...
Tim A. M. Bouwens van der Vlis +7 more
wiley +1 more source
ENDOPHENOTYPE AND PSYCHIATRY: AN INTERESTING COMBINATION [PDF]
, 2021 The endophenotype is a measurable component which is characterized as an intermediate part of the path existing between the genotype and phenotype of a disease.
Juli, Giada, Juli, Rebecca, Juli, Luigi
core +1 more source
Frontiers in Behavioral Neuroscience, 2020 Prepulse inhibition (PPI) of the startle reflex is a measure of sensory-motor synchronization. A deficit in PPI has been observed in psychiatric patients, especially those with schizophrenia and vulnerable subjects, since the neural bases of this ...
M. Carmen Arenas +3 more
doaj +1 more source
Endophenotype: a conceptual analysis [PDF]
Molecular Psychiatry, 2010 This paper provides a conceptual analysis of the endophenotype (EP) construct that is having an increasing role in genetic strategies for unraveling the etiology of psychiatric disorders (PDs). We make six major points illustrated through the method of path analysis.
K S, Kendler, M C, Neale
openaire +2 more sources
A Brain-based Endophenotype For Major Depressive Disorder [PDF]
, 2011 We have identified a brain-based endophenotype for major depressive disorder (MDD) that includes thinning of the cortex of the lateral aspect of the right hemisphere and the medial aspect of the left, as well as bilateral hypoplasia of frontal and ...
Weissman, Myrna M., Peterson, Bradley S.
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Extension of the Generalized Disequilibrium Test to polytomous phenotypes and two-locus models
Frontiers in Genetics, 2014 We extend the usual logistic model between a dichotomous phenotype and an allele count in two ways: a polytomous phenotype with K > 2 levels, and modelling of allele counts at two unlinked marker loci.
Alexandre eBureau +7 more
doaj +1 more source
Advances in endophenotyping schizophrenia [PDF]
World Psychiatry, 2008 The search for the genetic architecture of schizophrenia has employed multiple, often converging strategies. One such strategy entails the use of tracing the heritability and neurobiology of endophenotypes. Endophenotypes are quantifiable traits not visible to the eye, which are thought to reflect an intermediate place on the path from genes to ...
David L, Braff +4 more
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The involvement of noradrenaline in rapid eye movement (REM) sleep mentation
Frontiers in Neurology, 2011 Noradrenaline, one of the main brain monoamines, has powerful central influences on neurobiological processes in the forebrain which support the mental activities occurring during the sleep–waking cycle. Noradrenergic neurons are activated during waking,
Claude eGottesmann
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