Results 11 to 20 of about 20,878 (232)
All that glisters is not an endophenotype: rethinking endophenotypes in anorexia nervosa [PDF]
European Child & Adolescent Psychiatry, 2016 Dahlgren, CL, Micali, N
core +6 more sources
Digit ratio as an endophenotype in a schizophrenia population
South African Journal of Psychiatry, 2021 Background: Schizophrenia is a debilitating mental health condition affecting the lives of many South Africans. The origins of the heterogeneity in the presentation of the illness remain uncertain.
Wilhelm D.B. Nieuwoudt +4 more
doaj +1 more source
TULP4, a novel E3 ligase gene, participates in neuronal migration as a candidate in schizophrenia
CNS Neuroscience &Therapeutics, EarlyView., 2023 Mutations identified from four SCZ pedigrees resulted in decreased TULP4 expression. Tulp4 knockdown caused delayed neuron migration in embryonic mice, and impaired cognition and prepulse inhibition in adult mice. These phenotypes may be related to TULP4 through its involvement in the formation of a novel E3 ubiquitin ligases.
Yan Bi +19 more
wiley +1 more source
Neuromodulation: Technology at the Neural Interface, EarlyView., 2021 Abstract Introduction Deep brain stimulation (DBS) is an effective treatment for refractory obsessive–compulsive disorder (OCD). Neuropsychological assessment contributes to DBS treatment in several ways: it monitors the cognitive safety of the treatment, identifies beneficial or detrimental cognitive side effects and it could aid to explain ...
Tim A. M. Bouwens van der Vlis +7 more
wiley +1 more source
Frontiers in Behavioral Neuroscience, 2020 Prepulse inhibition (PPI) of the startle reflex is a measure of sensory-motor synchronization. A deficit in PPI has been observed in psychiatric patients, especially those with schizophrenia and vulnerable subjects, since the neural bases of this ...
M. Carmen Arenas +3 more
doaj +1 more source
Whole-brain functional hypoconnectivity as an endophenotype of autism in adolescents
NeuroImage: Clinical, 2015 Endophenotypes are heritable and quantifiable markers that may assist in the identification of the complex genetic underpinnings of psychiatric conditions. Here we examined global hypoconnectivity as an endophenotype of autism spectrum conditions (ASCs).
R.L. Moseley +9 more
doaj +1 more source
Error-related brain activity as a transdiagnostic endophenotype for obsessive-compulsive disorder, anxiety and substance use disorder [PDF]
, 2019 Background Increased neural error-signals have been observed in obsessive-compulsive disorder (OCD), anxiety disorders, and inconsistently in depression. Reduced neural error-signals have been observed in substance use disorders (SUD). Thus, alterations
Bey, Katharina +8 more
core +1 more source
Frontiers in Genetics, 2015 Effects of genetic variants on the risk of complex diseases estimated from association studies are typically small. Nonetheless, variants may have important effects in presence of specific levels of environmental exposures, and when a trait related to ...
Alexandre eBureau +7 more
doaj +1 more source
Editorial: Standardizing cognitive endophenotype profiling in bipolar disorder and schizophrenia [PDF]
Frontiers in PsychologyPau Soldevila-Matías +13 more
doaj +2 more sources
Pdxdc1 modulates prepulse inhibition of acoustic startle in the mouse. [PDF]
, 2017 Current antipsychotic medications used to treat schizophrenia all target the dopamine D2 receptor. Although these drugs have serious side effects and limited efficacy, no novel molecular targets for schizophrenia treatment have been successfully ...
Boutros, PC +5 more
core +1 more source