Results 41 to 50 of about 4,269 (166)

Hypertension in obesity: A focus on individualized pharmacotherapy and the role of body composition, on behalf of the European Society of Hypertension Working Group on Diabetes and Metabolic Risk Factors and Working Group on Lifestyle, Cardiovascular Pharmacotherapy and Adherence

British Journal of Clinical Pharmacology, EarlyView.
Hypertension in obesity represents a major global health challenge, closely linked to the global epidemics of obesity, type 2 diabetes and metabolic dysfunction. Excess adiposity contributes to elevated blood pressure through multiple, interrelated mechanisms, including activation of the renin–angiotensin–aldosterone system, sympathetic nervous system ...
Christina Antza, Andrej Belancic, Jens Jordan, Alberto Esteban, Anna Oliveras, Ryan McNally, Panagiota Anyfanti, Jorie Versmissen, María S. Fernández‐Alfonso, Vasilios Kotsis, Thomas Weber, Alexandre Persu, Reinhold Kreutz   +12 more
wiley   +1 more source

sj-docx-1-anp-10.1177_00048674211047189 – Supplemental material for A biomarker and endophenotype for anorexia nervosa?

, 2021
Supplemental material, sj-docx-1-anp-10.1177_00048674211047189 for A biomarker and endophenotype for anorexia nervosa? by Andrea Phillipou, Susan L Rossell, Caroline Gurvich, David J Castle, Denny Meyer and Larry A Abel in Australian & New Zealand ...
Denny Meyer (828573), Andrea Phillipou (2580517), Caroline Gurvich (2580529), Larry A Abel (13143688), Susan L Rossell (5197346), David J Castle (8123582)   +5 more
core   +1 more source

Altered cortical synchronization in photosensitive idiopathic generalized epilepsy

Epilepsia, EarlyView.
Abstract Objective To characterize cortical excitability and synchronization dynamics in patients with idiopathic generalized epilepsy (IGE) and photosensitivity by assessing steady‐state visual evoked potentials (SSVEPs) elicited by intermittent photic stimulation.
Alessandro Benedetto, Cecilia Steinwurzel, Francesco Turco, Enrica Bonanni, Roberto Cantello, Gionata Strigaro   +5 more
wiley   +1 more source

Can neurological soft signs and neurocognitive deficits serve as a combined endophenotype for Han Chinese with bipolar disorder?

International Journal of Methods in Psychiatric Research, 2023
Background Bipolar disorder's (BD) potential endophenotypes include neurological soft signs (NSS) and neurocognitive disorders (ND). Few research, meanwhile, has coupled NSS and ND as combined endophenotypes of BD.
Yingying Feng, Jia Song, Guorong Lin, Hong Qian, Li Feng, Zongqin Wang, Juan Wen, Chengchen Wang, Jiayuan Wang, Peifu Li, Zuohui Gao, Xiaoli Wang, Xiaohua Hu   +12 more
doaj   +1 more source

Characteristics of Multimodal Brain Connectomics in Patients With Schizophrenia and the Unaffected First-Degree Relatives

Frontiers in Cell and Developmental Biology, 2021
ObjectiveIncreasing pieces of evidence suggest that abnormal brain connectivity plays an important role in the pathophysiology of schizophrenia. As an essential strategy in psychiatric neuroscience, the research of brain connectivity-based neuroimaging ...
Xiao Lin, WeiKai Li, Guangheng Dong, Qiandong Wang, Hongqiang Sun, Jie Shi, Yong Fan, Peng Li, Lin Lu, Lin Lu, Lin Lu   +10 more
doaj   +1 more source

Predicting levetiracetam neuropsychiatric adverse effects using graph‐theoretical electroencephalographic network metrics in drug‐naive focal epilepsy: A multicenter longitudinal study

Epilepsia, EarlyView.
Abstract Objective Levetiracetam (LEV) is an antiseizure medication approved for focal and generalized epilepsy. Despite its efficacy, neuropsychiatric adverse effects (NP‐AEs) may lead to treatment discontinuation. Quantitative electroencephalographic (qEEG) graph‐theoretical analysis has emerged as a valuable tool for identifying neurophysiological ...
Marco Sferruzzi, Lorenzo Ricci, Margherita Anna Grazia Matarrese, Francesca Izzi, Fabio Placidi, Biagio Maria Sancetta, Emanuele Cerulli Irelli, Patrizia Pulitano, Vincenzo Di Lazzaro, Mario Tombini, Giovanni Assenza   +10 more
wiley   +1 more source

Discovering Endophenotypes for Major Depression [PDF]

Neuropsychopharmacology, 2004
The limited success of genetic studies of major depression has raised questions concerning the definition of genetically relevant phenotypes. This paper presents strategies to improve the phenotypic definition of major depression by proposing endophenotypes at two levels: First, dissecting the depressive phenotype into key components results in narrow ...
Gregor, Hasler, Wayne C, Drevets, Husseini K, Manji, Dennis S, Charney   +3 more
openaire   +2 more sources

Theory of mind: A cognitive endophenotype of juvenile myoclonic epilepsy?

Epilepsia, EarlyView.
Abstract Objective Juvenile myoclonic epilepsy (JME), the most common idiopathic generalized epilepsy, is associated with neuropsychological and psychiatric comorbidities, including social cognition and theory of mind (ToM) deficits. The interplay between clinical features, social cognition, and their neural and genetic substrates remains poorly ...
Bernardo Crespo‐Pimentel, Lucas J. Rainer, Mario Braun, Martin Kronbichler, Patrick Langthaler, Lisa Kronbichler, Sarah Said‐Yürekli, Laura Zamarian, Hennric Jokeit, Kornelius Winds, Elias Legat, Eugen Trinka, Julia Höfler, Giorgi Kuchukhidze   +13 more
wiley   +1 more source

Gut‐microbiota‐brain Axis and post‐traumatic epilepsy

Epilepsia Open, EarlyView.
Abstract There has been growing evidence that perturbations in gut‐microbiota‐brain axis (GMBA) are involved in mechanisms of chronic sequelae of traumatic brain injury (TBI). This review discusses the connection between GMBA and post‐traumatic epilepsy (PTE), the latter being a common outcome of TBI.
Andrey Mazarati
wiley   +1 more source

Alcoholism: the dissection for endophenotypes

Dialogues in Clinical Neuroscience, 2005
Alcohol dependence (alcoholism) is a complex disorder attributed to the interaction of genetic and environmental factors that form a collage of "disease" predisposition, which is not identical for every alcohol-dependent individual. There is considerable evidence to demonstrate that genetic predisposition accounts for roughly half the risk in the ...
Lisa M, Hines, Lara, Ray, Kent, Hutchison, Boris, Tabakoff   +3 more
openaire   +3 more sources