Results 51 to 60 of about 20,878 (232)
On the importance of including both sexes in animal studies – insights from home‐cage monitoring
Biological Reviews, EarlyView.ABSTRACT A review of behavioural studies using home‐cage monitoring (HCM) systems revealed that over 61% of studies used only male subjects, with only 24% including both sexes, despite evidence of substantial behavioural differences between male and female animals. This bias could influence the outcomes of biomedical research.
Maša Čater +12 more
wiley +1 more source
Epilepsia, EarlyView.Abstract Understanding the mechanisms underlying post‐traumatic epilepsy (PTE) following traumatic brain injury (TBI), and developing strategies to prevent or modify its progression, has been the focus of large collaborative efforts within the epilepsy and TBI research communities for over a decade.
Elisa R. Zanier +82 more
wiley +1 more source
Frontiers in Pharmacology, 2022 Complex diseases are associated with a wide range of cellular, physiological, and clinical phenotypes. To advance our understanding of disease mechanisms and our ability to treat these diseases, it is critical to delineate the molecular basis and ...
Stephanie L. Hickey +7 more
doaj +1 more source
The antisaccade task as a research tool in psychopathology: A critical review [PDF]
, 2006 The antisaccade task is a measure of volitional control of behavior sensitive to fronto-striatal dysfunction. Here we outline important issues concerning antisaccade methodology, consider recent evidence of the cognitive processes and neural mechanisms ...
Ettinger, Ulrich, Hutton, Samuel
core +1 more source
Modeling dopaminergic and other processes involved in learning from reward prediction error: contributions from an individual differences perspective [PDF]
, 2014 Phasic firing changes of midbrain dopamine neurons have been widely characterized as reflecting a reward prediction error (RPE). Major personality traits (e.g., extraversion) have been linked to inter-individual variations in dopaminergic ...
Alan D. Pickering, Francesca Pesola
core +2 more sources
Gut‐microbiota‐brain Axis and post‐traumatic epilepsy
Epilepsia Open, EarlyView.Abstract There has been growing evidence that perturbations in gut‐microbiota‐brain axis (GMBA) are involved in mechanisms of chronic sequelae of traumatic brain injury (TBI). This review discusses the connection between GMBA and post‐traumatic epilepsy (PTE), the latter being a common outcome of TBI.
Andrey Mazarati
wiley +1 more source
Discovering Endophenotypes for Major Depression [PDF]
Neuropsychopharmacology, 2004 The limited success of genetic studies of major depression has raised questions concerning the definition of genetically relevant phenotypes. This paper presents strategies to improve the phenotypic definition of major depression by proposing endophenotypes at two levels: First, dissecting the depressive phenotype into key components results in narrow ...
Gregor, Hasler +3 more
openaire +2 more sources
European Eating Disorders Review, EarlyView.ABSTRACT Introduction Anorexia nervosa (AN) and autism are distinct conditions, yet individuals with AN often exhibit elevated autistic traits. These traits are linked to complex clinical presentations, but their impact on AN remains unclear. This longitudinal study investigates associations between autistic traits, AN symptoms, and weight recovery in ...
Janneke S. van der Linden +5 more
wiley +1 more source
Alcoholism: the dissection for endophenotypes
Dialogues in Clinical Neuroscience, 2005 Alcohol dependence (alcoholism) is a complex disorder attributed to the interaction of genetic and environmental factors that form a collage of "disease" predisposition, which is not identical for every alcohol-dependent individual. There is considerable evidence to demonstrate that genetic predisposition accounts for roughly half the risk in the ...
Lisa M, Hines +3 more
openaire +3 more sources
Assessment of Metabolic Parameters For Autism Spectrum Disorders [PDF]
, 2009 Autism is a brain development disorder that first appears during infancy or childhood, and generally follows a steady course without remission. Impairments result from maturation-related changes in various systems of the brain.
Ghosh, S +4 more
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