Results 51 to 60 of about 4,269 (166)

A network-based approach for isolating the chronic inflammation gene signatures underlying complex diseases towards finding new treatment opportunities

Frontiers in Pharmacology, 2022
Complex diseases are associated with a wide range of cellular, physiological, and clinical phenotypes. To advance our understanding of disease mechanisms and our ability to treat these diseases, it is critical to delineate the molecular basis and ...
Stephanie L. Hickey, Alexander McKim, Alexander McKim, Christopher A. Mancuso, Christopher A. Mancuso, Arjun Krishnan, Arjun Krishnan, Arjun Krishnan   +7 more
doaj   +1 more source

Auditory gamma‐band synchronization and attentional performance in juvenile myoclonic epilepsy

Epilepsia Open, EarlyView.
Abstract Objective Cognitive difficulties in juvenile myoclonic epilepsy (JME) are part of the clinical phenotype alongside epileptic seizures; however, the underlying neurophysiological mechanisms remain unclear. Auditory steady‐state responses (ASSRs) to repetitive 40‐ and 80‐Hz stimuli are widely used measures of gamma‐band oscillations (GBOs ...
Ryo Mitoma, Shunsuke Tamura, Yoji Hirano, Takako Mitsudo, Yubin Sung, Takahiko Mukaino, Takahiro Yamaguchi, Kou Matsumoto, Toshiaki Onitsuka, Shogo Hirano, Tomohiro Nakao, Noriko Isobe, Hiroshi Shigeto   +12 more
wiley   +1 more source

A cognitive endophenotype of autism in families with multiple incidence

, 2011
Twin and family studies have established that there is a strong genetic basis for autism spectrum disorders. To facilitate the identification of susceptibility genes and to study pathways from gene-brain to cognition a more refined endophenotype-based ...
Hagberg, Bibbi, Nydén, Agneta, Råstam, Maria, Goussé, Véronique, Råstam, Maria,, Lund University., Véronique Goussé, Maria Rastam, Agneta Nydén, Bibbi Hagberg   +9 more
core   +1 more source

Endophenotypes and child psychiatry [PDF]

British Journal of Psychiatry, 2001
The search for an appropriate way to define psychiatric phenotypes in order to enhance the discriminative capacity of linkage and association studies is increasingly recognised to be of crucial importance for understanding the genetic basis of both child and adult psychiatry ([Skuse, 1997][1]; [
openaire   +2 more sources

Is processing speed a valid cognitive endophenotype for bipolar disorder?

Objectives: The current study investigated whether a single brief cognitive assessment, processing speed, could be considered as a valid endophenotype for bipolar disorder (BD).
Etain B, Leboyer M, Bellivier F, Raust A, Daban C, Cochet B, Mathieu F, Scott J   +7 more
core   +4 more sources

Identifying Affective Patterns in Patients With Eating Disorders: A Latent Profile Analysis

European Eating Disorders Review, EarlyView.
ABSTRACT Background Emotional difficulties are common among individuals with Eating Disorders (EDs). Following Panksepp's theoretical model, which conceptualises primary emotional systems as the evolutionary foundation of personality, this study aimed to identify distinct profiles of primary emotional systems within a clinical eating disorder (ED ...
Rachele Fasolato, Chiara Bonetto, Rosa Bruna Dall’Agnola, Emily Boifava, Federica Bonora, Mariasole Castellazzi, Silvia Castelli, Doriana Cristofalo, Silvia Danese, Monica Ferlin, Stuart B. Murray, Martina Puglisi, Silvia Rigon, Antonio Elia Rizzo, Benedetta Signoretto, Corrado Barbui   +15 more
wiley   +1 more source

Emotion Processing Deficit in Euthymic Bipolar Disorder: A Potential Endophenotype [PDF]

, 2021
Background: Emotion processing deficits have been described in patients with bipolar disorder (BD) and are considered one of the core cognitive abnormalities in BD with endophenotype potential.
Reddy, Preethi V., Anandan, Saravanakumar, Vasu, Sunil Kalmady, Joseph, Boban, Agarwal, Sri Mahavir, Rakesh, Gopalkumar, Venkatasubramanian, Ganesan, Muralidharan, Kesavan, Narayanaswamy, Janardhanan C., Shivakumar, Venkatarama, Venkatarama Shivakumar, Janardhanan C. Narayanaswamy, Ganesan Venkatasubramanian, Preethi V. Reddy, Boban Joseph, Gopalkumar Rakesh, Sunil Kalmady Vasu, Sri Mahavir Agarwal, Saravanakumar Anandan, Kesavan Muralidharan   +19 more
core   +1 more source

Specific peptide enrichment strategies for neuropsychiatric disorders: From material design to diagnostic applications

Interdisciplinary Medicine, EarlyView.
This review outlines specific peptide enrichment strategies, including metal, magnetic oxides, functional polymers, and antibody‐based approaches, and their mechanisms, highlighting applications in biomarker discovery for major neurological and psychiatric disorders.
Xue Zhang, Yejiao Shi, Minghui Guo, Yang Huang, Yirong Wang, Leping Huang, Helena S. Azevedo, Honggang Hu, Xin Dong   +8 more
wiley   +1 more source

Differential Effects of Serotonin Transporter Genotype on Anxiety-Like Behavior and Cognitive Judgment Bias in Mice

Frontiers in Behavioral Neuroscience, 2019
In humans, the short allele of a common polymorphism in the serotonin transporter (5-HTT) gene is associated with a higher risk to develop depression and anxiety disorders.
Viktoria Krakenberg, Viktoria Krakenberg, Vanessa Tabea von Kortzfleisch, Vanessa Tabea von Kortzfleisch, Sylvia Kaiser, Sylvia Kaiser, Norbert Sachser, Norbert Sachser, S. Helene Richter, S. Helene Richter   +9 more
doaj   +1 more source

Chromatin Accessibility Profiling of the Canine Brain Reveals Regulatory Programs Associated With Dog‐Wolf Divergence and Human Psychiatric Risk

Integrative Zoology, EarlyView.
The dog is a valuable model for studying social behavior and neuropsychiatric disease. We generated an ATAC‐seq atlas of 7 brain regions and pituitary from 4 beagles, identifying 251,492 CREs. Integrating dog‐wolf divergence revealed tissue‐specific CREs overlapping divergent loci, including neuronal and neuroendocrine genes.
Biao Deng, Junze Wu, Ye Liu, Xuan Li, Yuanfang Xu, Rongjie Duan, Yibo Tong, Jinsheng Xu, Mengyang Ni, Zijie Scott Zhang, Dan Xue, Bowen Zhou, Yanhu Liu, Rui Cheng, Yuedong Zhang, Ya‐Ping Zhang   +15 more
wiley   +1 more source