Results 61 to 70 of about 20,878 (232)

Relationship between endophenotype and phenotype in ADHD [PDF]

, 2008
Background: It has been hypothesized that genetic and environmental factors relate to psychiatric disorders through the effect of intermediating, vulnerability traits called endophenotypes.
Altink, M.E., Buitelaar, J., Buschgens, C., Faraone, S.V., Martin, N.C., Oosterlaan, J., Rommelse, N.N.J., Sergeant, J.A.   +7 more
core   +2 more sources

Dietary and biomarker‐guided strategies as supportive measures in the fragile X syndrome

Food Biomacromolecules, EarlyView.
Abstract The fragile X syndrome (FXS) is an inherited neurodevelopmental disorder that primarily affects males, often resulting in an IQ below 55, while about two‐thirds of females also experience intellectual disability. Physical features may include an elongated face, prominent ears, finger joint laxity, and enlarged testes in males.
Jailan E. El Halawani, Reem R. AlOlaby
wiley   +1 more source

Differential Effects of Serotonin Transporter Genotype on Anxiety-Like Behavior and Cognitive Judgment Bias in Mice

Frontiers in Behavioral Neuroscience, 2019
In humans, the short allele of a common polymorphism in the serotonin transporter (5-HTT) gene is associated with a higher risk to develop depression and anxiety disorders.
Viktoria Krakenberg, Viktoria Krakenberg, Vanessa Tabea von Kortzfleisch, Vanessa Tabea von Kortzfleisch, Sylvia Kaiser, Sylvia Kaiser, Norbert Sachser, Norbert Sachser, S. Helene Richter, S. Helene Richter   +9 more
doaj   +1 more source

Seasonal changes in brain serotonin transporter binding in short 5-HTTLPR-allele carriers but not in long-allele homozygotes [PDF]

, 2008
Several findings suggest seasonal variations in the serotonin (5-HT) system. We sought evidence for seasonal variation in the serotonin transporter (5-HTT).
David Erritzoe, Finn A. Nielsen, Gitte M. Knudsen, Jan Kalbitzer, Klaus K. Holst, Lisbeth Marner, Szabolcs Lehel, Terry L. Jernigan, Tine Arentzen   +8 more
core   +1 more source

Endophenotypes and child psychiatry [PDF]

British Journal of Psychiatry, 2001
The search for an appropriate way to define psychiatric phenotypes in order to enhance the discriminative capacity of linkage and association studies is increasingly recognised to be of crucial importance for understanding the genetic basis of both child and adult psychiatry ([Skuse, 1997][1]; [
openaire   +2 more sources

Neurodevelopmental variations cascading from age 10 months to 3 years leading to attention‐deficit hyperactivity disorder/autism traits at age 9 in a general population

JCPP Advances, EarlyView.
Associations of neurodevelopmental measures (Z‐scores of gross motor, visual reception, fine motor, receptive language, expressive language) at ages 10, 14, 18, 24, 32, and 40 months with (a) attention‐deficit/hyperactivity disorder trait, (b) autism spectrum disorder trait, (c) developmental coordination disorder trait, and (d) intellectual ...
Kenji J. Tsuchiya, Nagahide Takahashi, Yoko Nomura, Jeffrey H. Newcorn, Shigenobu Toda, Yuuka Ishikawa‐Omori, Akemi Okumura, Mohammad Shafiur Rahman, Toshiki Iwabuchi, Taeko Harada, Ikue Hirata, Chikako Nakayasu, Yuko Amma, Haruka Suzuki, Tomoko Nishimura   +14 more
wiley   +1 more source

Transcriptome-Wide Association Supplements Genome-Wide Association in Zea mays. [PDF]

, 2019
Modern improvement of complex traits in agricultural species relies on successful associations of heritable molecular variation with observable phenotypes. Historically, this pursuit has primarily been based on easily measurable genetic markers.
Bandillo, Nonoy B, Buckler, Edward S, Diepenbrock, Christine H, Gore, Michael A, Kremling, Karl AG   +4 more
core   +1 more source

Conditional Modeling of GNAO1 Disorder Dissociates Circuit Specific Contributions to Pathology and Rationalizes Ameliorative Strategies

Movement Disorders, EarlyView.
Abstract Background Neurodevelopmental disorders feature various symptoms that frequently include seizures and motor manifestations, but their attribution to disruptions of specific circuits and molecular alterations is notoriously hard to establish, which limits therapeutic interventions.
Gloria Brunori, Stefano Zucca, Colten K. Lankford, Yi‐Zhi Wang, Marianna Franco, Nina A. Alekseeva, Sevinj Ahmedova, Han My Van, Jeffrey N. Savas, Kirill A. Martemyanov   +9 more
wiley   +1 more source

Psychedelics, entactogens and psychoplastogens for depression and related disorders

British Journal of Pharmacology, EarlyView.
Currently, the most actively investigated rapidly acting antidepressants, anxiolytics and/or anti PTSD agents, include psychedelics e.g. psilocybin, LSD, N,N‐dimethyltryptamine, ayahuasca; non‐hallucinogenic entactogens, e.g. MDMA; psychoplastogens which rapidly promote neuroplasticity, e.g.
Daniel Hoyer
wiley   +1 more source

Theory of mind in schizophrenia through a clinical liability approach: a sib-pair study

Frontiers in Psychology
BackgroundConsistent findings indicate that Theory of Mind (ToM) is impaired in schizophrenia (SZ). To investigate whether such deficits are trait- or state-dependent, we investigated if ToM is modified by clinical liability markers (such as basic ...
M. Giralt-López, M. Giralt-López, M. Giralt-López, S. Miret, S. Miret, S. Miret, S. Campanera, M. Moreira, M. Moreira, M. Moreira, A. Sotero-Moreno, A. Sotero-Moreno, MO. Krebs, L. Fañanás, L. Fañanás, M. Fatjó-Vilas, M. Fatjó-Vilas, M. Fatjó-Vilas   +17 more
doaj   +1 more source