Results 81 to 90 of about 20,878 (232)

Building a Brief Multidomain Questionnaire for Gambling Dual Disorder: Psychometric Validation and RDoC‐Based Dimensional Structure

open access: yesInternational Journal of Methods in Psychiatric Research, Volume 35, Issue 2, June 2026.
ABSTRACT Objectives Gambling Disorder (GD) frequently co‐occurs with other mental disorders, a clinical condition termed Gambling Dual Disorder (GDD) that is often overlooked. We aimed to develop and validate a brief multidomain questionnaire to assess GDD severity within a dimensional, transdiagnostic framework.
Ignacio Basurte‐Villamor   +6 more
wiley   +1 more source

Endophenotypes of psychosis [PDF]

open access: yesAnnals of General Psychiatry, 2008
There is growing appreciation that the major psychiatric disorders may be composed of sub-syndromes that can be characterized by specific pathophysiological markers. For example, schizophrenia can be deconstructed into several separable sub-syndromes i.e., psychosis, negative symptoms, and mood instability.
openaire   +2 more sources

Amine Metabolism Is Influenced by Dietary Protein Source

open access: yesFrontiers in Nutrition, 2017
Growth in world population will inevitably leads to increased demand for protein for humans and animals. Protein from insects and blood plasma are being considered as possible alternatives, but more research on their nutritional quality and health ...
Soumya K. Kar   +10 more
doaj   +1 more source

The Role of Dopamine in Anticipatory Pursuit Eye Movements: Insights from Genetic Polymorphisms in Healthy Adults [PDF]

open access: yes, 2016
There is a long history of eye movement research in patients with psychiatric diseases for which dysfunctions of neurotransmission are considered to be the major pathologic mechanism.
Billino, Jutta   +2 more
core   +1 more source

From Molecular Pathology to Cognitive Phenotypes: The Emerging Role of Artificial Intelligence in Neuroimaging

open access: yes
iRADIOLOGY, EarlyView.
Xiaohui Zhang   +6 more
wiley   +1 more source

Genetic Contribution to Asthma Informs Acute Chest Syndrome Pathophysiology and Risk Stratification

open access: yesAmerican Journal of Hematology, Volume 101, Issue 5, Page 961-971, May 2026.
ABSTRACT Acute chest syndrome (ACS) is a severe complication of sickle cell disease (SCD) occurring in ~50% of patients, some presenting frequent episodes. We lack tools to identify patients at high risk of ACS occurrence or frequent episodes. Epidemiological studies have found an association between asthma and ACS, but whether this link is causal is ...
Sara El Aouhel   +10 more
wiley   +1 more source

Evaluating the causal effect of mitochondrial dysfunction on Alzheimer's disease and Parkinson's disease using polygenic risk scores and Mendelian randomization

open access: yesAlzheimer's &Dementia, Volume 22, Issue 5, May 2026.
Abstract INTRODUCTION Mitochondrial DNA copy number (mtDNAcn), a measure of mitochondrial genomes per nucleated cell, has an unclear causal relationship with Alzheimer's disease (AD) and Parkinson's disease (PD). We integrated genetic correlation, polygenic risk scores (PRSs), and Mendelian randomization (MR) to assess whether mtDNAcn influences the ...
Aadrita Chatterjee   +10 more
wiley   +1 more source

Adjudicating neurocognitive endophenotypes for schizophrenia

open access: yesAmerican Journal of Medical Genetics Part B: Neuropsychiatric Genetics, 2006
AbstractAlthough genetic influences on schizophrenia are well established, localization of the genes responsible for this illness has proven extremely difficult. Given evidence that genes predisposing to schizophrenia may be transmitted without expression of the clinical phenotype, efforts have focused on developing endophenotypes.
Burk, Gary   +11 more
openaire   +4 more sources

White Matter Tract Alterations in Bipolar Disorder: A Systematic Review and Meta‐Analysis of Diffusion Tensor Imaging Studies

open access: yesBrain and Behavior, Volume 16, Issue 5, May 2026.
This systematic review and meta‐analysis synthesizes diffusion tensor imaging evidence of white matter microstructural abnormalities in bipolar disorder. Across published studies, patients with bipolar disorder showed reduced fractional anisotropy in several major white matter tracts, including the corpus callosum, cingulum bundle, corona radiata ...
Behnaz Mahmoudvand   +18 more
wiley   +1 more source

Endophenotypes in the personality disorders

open access: yesDialogues in Clinical Neuroscience, 2005
The identification of endophenotypes in the personality disorders may provide a basis for the identification of underlying genotypes that influence the traits and dimensions of the personality disorders, as well as susceptibility to major psychiatric illnesses.
openaire   +3 more sources

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