Results 91 to 100 of about 4,269 (166)

Does performance on the standard antisaccade task meet the co-familiality criterion for an endophenotype?

, 2008
Does performance on the standard antisaccade task meet the co-familiality criterion for an ...
V Krause (13479856), NR Mendell (14464548), DL Levy (14464545), Larry Abel (13056207), EA Bowman (14464509), O Krastoshevsky (13479853)   +5 more
core  

Model endophenotype for bipolar disorder: Qualitative Analysis, etiological factors, and research areas [PDF]

, 2014
The aim of this study is to present an updated view of the writings on the endophenotype model for bipolar disorder using analytical methodologies. A review and analysis of networks was performed through descriptors and keywords that characterize the ...
Naraiana de Oliveira Tavares, Fernando da Silva Neves, Leandro Fernandes Malloy-Diniz, Tavares, Naraiana de Oliveira, Neves, Fernando da Silva, Malloy-Diniz, Leandro Fernandes   +5 more
core   +1 more source

Attention Deficits in a Comorbidity-Free Sample of Euthymic Pediatric Bipolar Disorder

Frontiers in Psychiatry, 2019
Attention deficits are considered one of the potential endophenotypic markers of Bipolar Disorder (BD). Pediatric bipolar disorder (PBD) likely has stronger genetic underpinnings than adult onset BD; therefore, demonstrating attention deficits in PBD can
Nandini Banerjee, Shi-Kai Liu, Vinod K. Sinha, Meera Jayaswal, Pushpal Desarkar   +4 more
doaj   +1 more source

Starting at the endophenotype: A role for alpha-CaMKII in schizophrenia? [PDF]

, 2008
Using an endophenotype-driven screen, a new study finds that α-calcium/calmodulin kinase II mutant mice exhibit a range of behavioral abnormalities related to schizophrenia.
Paul W Frankland, Frankland Paul W, Sakaguchi Masanori, Maithé Arruda-Carvalho, Arruda-Carvalho Maithé, Frankland, Paul W, Masanori Sakaguchi, Arruda-Carvalho, Maithé, Sakaguchi, Masanori   +8 more
core   +1 more source

Mouse behavioral endophenotypes for schizophrenia

Brain Research Bulletin, 2010
An endophenotype is a heritable trait that is generally considered to be more highly, associated with a gene-based neurological deficit than a disease phenotype itself. Such, endophenotypic deficits may therefore be observed in the non-affected relatives of disease patients.
Laura C, Amann, Michael J, Gandal, Tobias B, Halene, Richard S, Ehrlichman, Samantha L, White, Hilary S, McCarren, Steven J, Siegel   +6 more
openaire   +2 more sources

Irony comprehension in first-degree relatives of patients with bipolar affective disorder – a preliminary fMRI study

Frontiers in Psychiatry
IntroductionMentalization or Theory of Mind (ToM) is crucial for interpreting social situations and understanding others’ beliefs and intentions. Irony comprehension, which involves constructing a coherent narrative from contradictory information, is ...
András Sándor Hajnal, Eszter Varga, Tamás Tényi, Borbála Pethő, Noémi Albert, Márton Herold, Márton Áron Kovács, Tímea Csulak, Dóra Hebling, Róbert Herold   +9 more
doaj   +1 more source

Deconstructing the resting state: Exploring the temporal dynamics of frontal alpha asymmetry as an endophenotype for depression

Frontiers in Human Neuroscience, 2010
Asymmetry in frontal electrocortical alpha-band (8-13 Hz) activity recorded during resting situations (i.e., in absence of a specific task) has been investigated in relation to emotion and depression for over 30 years.
John J. B. Allen, Michael X eCohen, Michael X eCohen   +2 more
doaj   +1 more source

Motor abnormalities as a putative endophenotype for Autism Spectrum Disorders

Frontiers in Integrative Neuroscience, 2013
Autism spectrum disorders (ASDs) represent a complex group of behaviorally defined conditions with core deficits in social communication and the presence of repetitive and restrictive behaviors.
Gianluca eEsposito, Sergiu ePasca
doaj   +1 more source

EndoPRS: Incorporating Endophenotype Information to Improve Polygenic Risk Scores for Clinical Endpoints [PDF]

Polygenic risk score (PRS) prediction of complex diseases can be improved by leveraging related phenotypes. This has motivated the development of several multi-trait PRS methods that jointly model information from genetically correlated traits.
Auer, Paul L., Mathias, Rasika A., Li, Yun, Ober, Carole, Kelada, Samir, Kharitonova, Elena V., Tao, Ran, Chen, Brian, Zhou, Laura Y., Sun, Quan, Ockerman, Frank, Raffield, Laura M., Cox, Nancy J., Cao, Hongyuan, Reiner, Alexander P.   +14 more
core   +1 more source

Genetically stratified Parkinson’s disease with freezing of gait is related to specific pattern of cognitive impairment and non-motor dominant endophenotype

Frontiers in Aging Neuroscience
BackgroundFreezing of gait (FOG) is an important milestone in the individual disease trajectory of people with Parkinson’s disease (PD). Based on the cognitive model of FOG etiology, the mechanism behind FOG implies higher executive dysfunction in PDFOG+.
Lukas Pavelka, Lukas Pavelka, Lukas Pavelka, Rajesh Rawal, Stefano Sapienza, Jochen Klucken, Jochen Klucken, Jochen Klucken, Claire Pauly, Claire Pauly, Claire Pauly, Venkata Satagopam, Rejko Krüger, Rejko Krüger, Rejko Krüger   +14 more
doaj   +1 more source