Results 61 to 70 of about 1,379 (186)

The range of validity of cluster masses and ages derived from broad-band photometry [PDF]

Proceedings of the International Astronomical Union, 2009
AbstractI analyze the stochastic effects introduced by sampling the stellar initial mass function (SIMF) in the derivation of the individual masses and the cluster mass function (CMF) from broad-band visible/near-infrared unresolved photometry. The classical method of using unweighted U BV photometry to simultaneously establish ages and extinctions of ...
openaire   +2 more sources

Peroxisome Proliferator‑Activated Receptor Gamma Coactivator‑1α Deficiency in Hippocampal Astrocytes Underlies Enhanced Fear Memory Retrieval in Male Posttraumatic Stress Disorder Model Mice

MedComm, Volume 7, Issue 3, March 2026.
PGC‑1α downregulation in hippocampal astrocytes disrupts ATP release and reduces connexin 43 (CX43) expression, impairing neuro‑glial communication. This promotes enhanced fear memory retrieval in PTSD. Chemogenetic activation of astrocytes or PGC‑1α agonist treatment rescues both CX43 expression and fear behavior, identifying astrocytic PGC‑1α/CX43 as
Juan Wang, Xiaoyu Chen, Daokang Chen, Shaojie Yang, Jingji Wang, Ming Chen, Guoqi Zhu   +6 more
wiley   +1 more source

The Pre-perihelion Evolution of the Activity of Comet C/2017 K2 (Pan-STARRS) during the Water Ice-line Crossover

The Astronomical Journal
Comets, relics from the early solar system, consist of dust and ice. The ice sublimates as comets approach the Sun, ejecting dust from their nuclei seen as activity.
Yuna G. Kwon, Stefano Bagnulo, Johannes Markkanen, Ludmilla Kolokolova, Jessica Agarwal, Manuela Lippi, Zuri Gray   +6 more
doaj   +1 more source

Drug Product Development of Lipid Nanoparticle‐Based mRNA Therapeutics and Vaccines

WIREs Nanomedicine and Nanobiotechnology, Volume 18, Issue 2, March/April 2026.
Overview of the development path from an mRNA–lipid nanoparticle (LNP) concept to a licensed drug product, covering LNP design, manufacturing process development, formulation, and analytical characterization. ABSTRACT Lipid nanoparticles (LNP) are currently the most relevant non‐viral delivery systems for mRNA and occasionally for smaller nucleic acids
Gideon Kersten, Eleonora Cerasoli, Bruce Kerwin, Olivia M. Merkel, Andrea Hawe   +4 more
wiley   +1 more source

The Discovery of the Faintest Known Milky Way Satellite Using UNIONS

The Astrophysical Journal
We present the discovery of Ursa Major III/UNIONS 1, the least luminous known satellite of the Milky Way, which is estimated to have an absolute V -band magnitude of $+{2.2}_{-0.3}^{+0.4}$ mag, equivalent to a total stellar mass of ${16}_{-5}^{+6}$ M _⊙ .
Simon E. T. Smith, William Cerny, Christian R. Hayes, Federico Sestito, Jaclyn Jensen, Alan W. McConnachie, Marla Geha, Julio F. Navarro, Ting S. Li, Jean-Charles Cuillandre, Raphaël Errani, Ken Chambers, Stephen Gwyn, Francois Hammer, Michael J. Hudson, Eugene Magnier, Nicolas Martin   +16 more
doaj   +1 more source

Review of Existing Approaches and Potential Role of Pharmacometrics in the Interpretation of Prognostic Circulating Serum Biomarkers in Advanced NSCLC

Clinical and Translational Science, Volume 19, Issue 3, March 2026.
ABSTRACT Circulating serum biomarkers have prognostic value in patients with advanced NSCLC, yet their potential still remains underappreciated at present. This review discusses classical approaches of biomarker data analysis, highlighting gaps, and summarizing current methodologies to evaluate the relationship between serum biomarkers and clinical ...
Francis Williams Ojara, Yomna M. Nassar, Kimberly Geiger, Madele van Dyk, Stefan Holdenrieder, Markus Joerger, Charlotte Kloft   +6 more
wiley   +1 more source

Brightness Behavior of Distant Oort Cloud Comets

The Planetary Science Journal
Dynamically new comets provide important insights into the conditions of the presolar nebula and its evolution, as they are believed to have experienced minimal solar heating before their discovery.
Carrie E. Holt, Matthew M. Knight, Michael S. P. Kelley, Tim Lister, Quanzhi Ye, Colin Snodgrass, Cyrielle Opitom, Rosita Kokotanekova, Megan E. Schwamb, Matthew M. Dobson, Michele T. Bannister, Marco Micheli, Stefanie N. Milam, Derek C. Richardson, The LCO Outbursting Objects Key (LOOK) Project, Edward Gomez, Joseph P. Chatelain, Sarah Greenstreet   +17 more
doaj   +1 more source

Spectral and Photometric Studies of NGC 4151 in the Optical Range: Current Results

Universe
We present the results of long-term photometric and spectroscopic monitoring of the Seyfert galaxy NGC 4151 based on new observational data complemented by archival material spanning several decades. NGC 4151 is one of the most extensively studied active
Nazim Huseynov, Saule Shomshekova, Alexander Serebryanskiy, Luydmila Kondratyeva, Samira Rahimli, Gabit Nazymbekov, Inna Reva, Gaukhar Aimanova   +7 more
doaj   +1 more source

ULTI-WAVELENGTH MONITORING OF THE CHANGING-LOOK AGN NGC 2617 DURING STATE CHANGES

Odessa Astronomical Publications, 2017
Optical  and  near-infrared  photometry, optical spectroscopy, and  soft X-ray and UV  monitoring of  the  changing-look  active  galactic  nucleus  NGC  2617 show that it continues to have the appearance of a type-1 Seyfert galaxy.
V. L. Oknyansky, C. M. Gaskell, N. A. Huseynov, Kh. M. Mikailov, V. M. Lipunov, N. I. Shatsky, S. S. Tsygankov, E. S. Gorbovskov, A. M. Tatarnikov, V. G. Metlov, K. L. Malanchev, M. B. Brotherton, D. Kasper, P. Du, X. Chen, M. A. Burlak, D. A. H. Buckley, R. Rebolo, M. Serra-Ricart, R. Podesta, H. Levato   +20 more
doaj   +1 more source

The fc fragment of IgMs binds C1q to activate the first step of the classical complement pathway, while inhibiting complement‐dependent cytotoxicity

The FEBS Journal, Volume 293, Issue 5, Page 1358-1375, March 2026.
Multimeric IgM‐fragment crystallizable region (Fc) fragments retain the ability to bind C1q and initiate the classical complement pathway, leading to C4 activation and deposition in vitro. However, the Fc cores can also inhibit complement‐dependent cytotoxicity by competing with surface‐bound antibodies for C1q engagement.
Andrea J. Pinto, Anne Chouquet, Isabelle Bally, Véronique Rossi, Nicole M. Thielens, Chantal Dumestre‐Pérard, Renate Kunert, Christine Gaboriaud, Wai Li Ling, Jean‐Baptiste Reiser   +9 more
wiley   +1 more source