Results 111 to 120 of about 1,283 (170)

Retrospective analysis of adverse drug reaction patterns from the national monitoring system in a tertiary care hospital in China (2019-2024). [PDF]

Open Med (Wars)
Yuan XL, Fang XY, Li F, Wang FJ, Ma QQ, Chen JT, Wang YN.   +6 more
europepmc   +1 more source

Field survey on warnings to prevent drug abuse when selling over-the-counter drugs at drugstores. [PDF]

Explor Res Clin Soc Pharm
Nagashima K, Nasu H, Sekine Y.
europepmc   +1 more source

[Bromhexine (Bisolvon) in chronic bronchitis].

Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke, 1972
openaire   +1 more source

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Bromhexine in the treatment of otitis media with effusion

Clinical Otolaryngology, 1985
In a double blind randomised trial of 95 children aged 3-8 years with otitis media with effusion (OME), the efficacy of the mucolytic agent bromhexine hydrochloride (Bisolvon) was compared with a placebo. Each child received two 4 week courses of either bromhexine or placebo in a random fashion.
I A, Stewart, A M, Guy, R S, Allison, N J, Thomson   +3 more
exaly   +3 more sources

Bioavailability of Bromhexine in the Horse

Zentralblatt für Veterinärmedizin Reihe A, 1980
SummaryBromhexine was administered orally (2 mg./kg.) and intravenously (i. v.) (1 mg./kg.) in 3 horses. Plasma levels were measured and the pharmacokinetic behaviour and bioavailability were estimated. The half‐life of elimination after i. v. administration ranged from 3.1 to 4.4 hours.
P, de Backer, L M, Vandecasteele-Thienpont, J A, Jonckheere, F M, Belpaire, M, Debackere, A P, de Leenheer   +5 more
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Bromhexine in severe asthma

British Journal of Diseases of the Chest, 1978
Fourteen patients with acute severe asthma necessitating hospital admission were all treated with a standard therapeutic regimen, and in addition received either bromhexine or placebo (initially intravenously and subsequently orally) double-blind. We were unable to show any significant improvement in the rate of recovery of the bromhexine-treated group,
M, Rudolf, J F, Riordan, B J, Grant, D J, Maberly, K B, Saunders   +4 more
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Elemental impurities determination in bromhexine hydrochloride injections

Journal of Pharmaceutical and Biomedical Analysis, 2023
Elemental impurities in drug products have no therapeutic effect and may pose toxicological concerns, therefore it is urgent to assess the safety of elements especially in parenteral exposure drug. In the present work, a high throughput inductively coupled plasma mass spectrometry (ICP-MS) method was developed for the quantitative determination of 31 ...
Shujuan, Xu, Lei, Zhang, Qingshan, Bai, Lihua, Wang, Xiao, Chen   +4 more
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Metabolism of bromhexine in pig hepatocyte cultures

Journal of Veterinary Pharmacology and Therapeutics, 2004
The metabolism of bromhexine [N‐cyclohexyl‐N‐methyl‐2‐(2‐amino‐3,5‐di‐bromo‐benzyl)‐amine] was studied using pig hepatocyte cultures and LC/MS/MS techniques. Phase I ‘single‐step’ reactions, i.e. hydroxylation and demethylation occurred the fastest whereas the formation of hydroxylated/demethylated and aminal hydroxylated metabolites, which can be ...
Meijer, L.A., Verstegen, J.C.M., Bull, S., Fink-Gremmels, J.   +3 more
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Bromhexine and mucociliary clearance in chronic bronchitis

British Journal of Diseases of the Chest, 1974
Abstract Lung mucociliary clearance was assessed in 9 patients with chronic bronchitis from the rate of removal of previously inhaled particles tagged with a radioisotope (99mTc) before and after the administration of bromhexine (Bisolvon) 16 mg three times daily.
M L, Thomson, D, Pavia, I, Gregg, J E, Stark   +3 more
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Determination of ambroxol or bromhexine in pharmaceuticals by capillary isotachophoresis

Journal of Pharmaceutical and Biomedical Analysis, 2001
Expectorant drugs ambroxol (AX) and bromhexine (BX) were determined by capillary isotachophoresis (ITP) with conductimetric detection. The leading electrolyte (LE) was a buffer solution that contained 5 mM picolinic acid and 5 mM potassium picolinate (pH 5.2). The terminating electrolyte (TE) was 10 mM formic acid.
M, Pospísilová, M, Polásek, V, Jokl
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