Results 111 to 120 of about 548 (160)
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British Journal of Diseases of the Chest, 1978
Fourteen patients with acute severe asthma necessitating hospital admission were all treated with a standard therapeutic regimen, and in addition received either bromhexine or placebo (initially intravenously and subsequently orally) double-blind. We were unable to show any significant improvement in the rate of recovery of the bromhexine-treated group,
M, Rudolf +4 more
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Fourteen patients with acute severe asthma necessitating hospital admission were all treated with a standard therapeutic regimen, and in addition received either bromhexine or placebo (initially intravenously and subsequently orally) double-blind. We were unable to show any significant improvement in the rate of recovery of the bromhexine-treated group,
M, Rudolf +4 more
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Elemental impurities determination in bromhexine hydrochloride injections
Journal of Pharmaceutical and Biomedical Analysis, 2023Elemental impurities in drug products have no therapeutic effect and may pose toxicological concerns, therefore it is urgent to assess the safety of elements especially in parenteral exposure drug. In the present work, a high throughput inductively coupled plasma mass spectrometry (ICP-MS) method was developed for the quantitative determination of 31 ...
Shujuan, Xu +4 more
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Metabolism of bromhexine in pig hepatocyte cultures
Journal of Veterinary Pharmacology and Therapeutics, 2004The metabolism of bromhexine [N‐cyclohexyl‐N‐methyl‐2‐(2‐amino‐3,5‐di‐bromo‐benzyl)‐amine] was studied using pig hepatocyte cultures and LC/MS/MS techniques. Phase I ‘single‐step’ reactions, i.e. hydroxylation and demethylation occurred the fastest whereas the formation of hydroxylated/demethylated and aminal hydroxylated metabolites, which can be ...
Meijer, L.A. +3 more
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Bromhexine and mucociliary clearance in chronic bronchitis
British Journal of Diseases of the Chest, 1974Abstract Lung mucociliary clearance was assessed in 9 patients with chronic bronchitis from the rate of removal of previously inhaled particles tagged with a radioisotope (99mTc) before and after the administration of bromhexine (Bisolvon) 16 mg three times daily.
M L, Thomson +3 more
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Bromhexine in the treatment of otitis media with effusion
Clinical Otolaryngology, 1985In a double blind randomised trial of 95 children aged 3-8 years with otitis media with effusion (OME), the efficacy of the mucolytic agent bromhexine hydrochloride (Bisolvon) was compared with a placebo. Each child received two 4 week courses of either bromhexine or placebo in a random fashion.
I A, Stewart +3 more
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Role of Bromhexine in Exacerbations of Bronchiectasis
Respiration, 2009The effectiveness of bromhexine in the treatment of patients with bronchiectasis, in a stage of clinical exacerbation, was assessed in a double-blind, placebo-controlled trial involving 88 in-patients. Bronchiectasis was diagnosed by bronchography and/or CT scan. Bromhexine or matched placebo was administered as 30-mg capsules three times daily per os.
D. Olivieri +5 more
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Surfactant in the amniotic fluid and bromhexine metabolite VIII
European Journal of Obstetrics & Gynecology and Reproductive Biology, 1978The effect of metabolite VIII of bromhexine on surfactant content in the amniotic fluid was investigated in a double blind study. Administration of 100 and 200 mg NA-872 daily for 5 days to pregnant women ranging in gestational age from 196 to 243 days was not followed by a significant rise in the L/S ratio.
J M, Merkus +3 more
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Pharmacokinetics of bromhexine in the dog.
Arzneimittel-Forschung, 1981Bromhexine hydrochloride was administered to dogs i.v. and p.o. Plasma determinations of the unchanged drug were carried out by gas-liquid chromatography with electron-capture detection. The plasma levels obtained after i.v. administration were consistent with a two-compartment open model. Comparison of the results of i.v.
L M, Vandecasteele-Thienpont +3 more
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