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Role of Bromhexine in Exacerbations of Bronchiectasis
Respiration, 2009The effectiveness of bromhexine in the treatment of patients with bronchiectasis, in a stage of clinical exacerbation, was assessed in a double-blind, placebo-controlled trial involving 88 in-patients. Bronchiectasis was diagnosed by bronchography and/or CT scan. Bromhexine or matched placebo was administered as 30-mg capsules three times daily per os.
D. Olivieri +5 more
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Surfactant in the amniotic fluid and bromhexine metabolite VIII
European Journal of Obstetrics & Gynecology and Reproductive Biology, 1978The effect of metabolite VIII of bromhexine on surfactant content in the amniotic fluid was investigated in a double blind study. Administration of 100 and 200 mg NA-872 daily for 5 days to pregnant women ranging in gestational age from 196 to 243 days was not followed by a significant rise in the L/S ratio.
J M, Merkus +3 more
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Pharmacokinetics of bromhexine in the dog.
Arzneimittel-Forschung, 1981Bromhexine hydrochloride was administered to dogs i.v. and p.o. Plasma determinations of the unchanged drug were carried out by gas-liquid chromatography with electron-capture detection. The plasma levels obtained after i.v. administration were consistent with a two-compartment open model. Comparison of the results of i.v.
L M, Vandecasteele-Thienpont +3 more
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EXPECTORANT PROPERTIES OF BROMHEXINE
The Lancet, 1970K N, Palmer, W F, Hamilton
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Bromhexine and its fumarate salt: Crystal structures, Hirshfeld surfaces and dissolution study
Journal of Molecular Structure, 2021Bai-Wang Sun
exaly