Clinical Features of Cellular Senescence Pathways in Severe Asthma
Allergy, EarlyView.In bronchial biopsies, SASP and p53 pathway enrichment scores are elevated in severe asthma versus non‐severe asthma and healthy controls. SASP enrichment is validated in the independent NOVA cohort. SASP enrichment is also elevated in nasal brushings of participants with nasal polyps, independently of asthma status.
Woo‐Jung Song +122 more
wiley +1 more source
Case Report: Adult fibrinous bronchitis associated with lymphatic reflux: a probable diagnosis based on convergent evidence. [PDF]
Front Med (Lausanne)Li H +6 more
europepmc +1 more source
Determinants of Poor Health‐Related Quality of Life in Patients With Food Allergy
Allergy, EarlyView.Machine‐learning analysis of 502 well‐characterised food‐allergic patients was used to identify key determinants of poor FA‐HRQL, defined as FAQLQ ≥ 5. The most relevant predictors were adult age, female sex, multiple food allergies, severe reactions, need for urgent care, onset before 18 years, and longer disease duration.
Rosialzira Natasha Vera‐Berrios +24 more
wiley +1 more source
Trends in the Overall Incidence and Mortality of Lung Cancer: An Extensive Longitudinal Study Utilizing the CDC WONDER Database 1999-2020. [PDF]
Thorac CancerYasinzai AQK +10 more
europepmc +1 more source
Therapeutic potential of natural products in cancer immunotherapy: Advances and challenges
British Journal of Pharmacology, EarlyView.This review systematically outlines the mechanisms underlying tumour immunotherapy resistance and elucidates the role of natural products in enhancing therapeutic efficacy as immunomodulatory adjuvants. Abstract Immunotherapy has emerged as a clinically pivotal approach in cancer treatment, but its application remains limited to a small subset of ...
Rao Hu +6 more
wiley +1 more source
Pulmonary artery pseudoaneurysm as a neglected manifestation of pulmonary mucormycosis: a retrospective observational study. [PDF]
BMC Infect DisNguyen-Thi BN +6 more
europepmc +1 more source
The metalloproteinase ADAM17 promotes acute lung inflammatory responses during pancreatitis
British Journal of Pharmacology, EarlyView.Background and Purpose Acute pancreatitis (AP) is a multifactorial upper gastrointestinal inflammatory disorder that in severe cases (~20% of all AP) is associated with substantial morbidity and mortality, the latter coincident with multiorgan dysfunction, particularly acute lung injury (ALI).
Shermin Chan +17 more
wiley +1 more source
Beyond the Usual Suspects: Rare Causes of Hemoptysis. [PDF]
Diagnostics (Basel)Sekulovic-Radovanovic I +3 more
europepmc +1 more source
British Journal of Pharmacology, EarlyView.Abstract Catecholamines are classically viewed as neuronal transmitters and adrenal hormones; however, accumulating evidence demonstrates that sources other than nerve fibres and adrenal medulla play a fundamental role in local organ regulation. Physiological paradoxes, such as preserved organ function after denervation or transplantation, challenge a ...
Mariana G. de Oliveira +3 more
wiley +1 more source