Results 41 to 50 of about 28,269 (237)

The effect of lipoprotein-associated phospholipase A2 deficiency on pulmonary allergic responses in Aspergillus fumigatus sensitized mice. [PDF]

, 2012
BackgroundLipoprotein-associated phospholipase A2 (Lp-PLA2)/platelet-activating factor acetylhydrolase (PAF-AH) has been implicated in the pathogenesis of cardiovascular disease.
Fehrenbach, Melane L, Haczku, Angela, Jiang, Zhilong, Kokalari, Blerina, Macphee, Colin, Ravaioli, Giulia, Redai, Imre G, Sheardown, Steven A, Wilson, Stephen   +8 more
core   +2 more sources

KCNJ2 is Required for NLRP3 Inflammasome Activation That Drives Allergic Airway Inflammation and Remodeling

Advanced Science, EarlyView.
This study aims to evaluate the impact of the potassium channel KCNJ2 on asthma development. KCNJ2 promotes NLRP3 inflammasome activation through both Ca2+ influx and K+ efflux in airway epithelial cells, which drives allergic airway inflammation and remodeling, suggesting a promising therapeutic target for asthma.
Yachao Cui, Shumei Wu, Yang Peng, Yiqi Liu, Li Che, Shiying Chen, Feng Zhang, Dajiang Qin, Shiyue Li, Pixin Ran, Wenguang Yin   +10 more
wiley   +1 more source

Role of neutral endopeptidase in endotoxin-induced bronchial hyperresponsiveness to substance P in guinea pigs

Allergology International, 1998
To investigate effects of endotoxin on allergic airway diseases, we studied bronchial responsiveness to histamine (HI) and substance P (SP) in actively sensitized and non-sensitized guinea pigs 24 h after exposure to endotoxin (75 (μg/mL; 40 min) and its
Shigenori Iwamae, Hideo Tsukagoshi, Takeshi Hisada, Daisuke Uno, Masatomo Mori   +4 more
doaj   +1 more source

Endogenous Ceramide 24:1 Constrains Th17‐Driven Neutrophilic Inflammation by Antagonizing EP2 Signaling

Advanced Science, EarlyView.
Cer24:1 levels are reduced in neutrophilic asthma and inversely correlate with disease severity and airway neutrophilia. Restoring Cer24:1 suppresses pathogenic Th17 differentiation by engaging EP2 on CD4+ T cells, thereby dampening the JAK2–STAT3–RORγt axis and reducing IL‐17 production.
Huan Liu, Abudureyimujiang Aili, Zheng Kuang, Liting Cao, Zemin Li, Ying Shang, Yingying Ge, Tingting Hu, Yongchang Sun, Wuli Zhao, Rong Jin, Chun Chang   +11 more
wiley   +1 more source

Relationship between Exhaled Nitric Oxide Measured by Two Offline Methods and Bronchial Hyperresponsiveness in Japanese Adults with Asthma

Allergology International, 2008
Background: Exhaled nitric oxide (eNO) is a useful marker of eosinophilic airway inflammation in asthmatics. There have been no studies to show the relationship between eNO measured by offline methods and the degree of bronchial hyperresponsiveness in ...
Takahiro Tsuburai, Naomi Tsurikisawa, Sonoko Morita, Hideki Hasunuma, Hiroshi Kanegae, Yasushi Ishimaru, Yuma Fukutomi, Hidenori Tanimoto, Emiko Ono, Chiyako Oshikata, Kiyoshi Sekiya, Mamoru Otomo, Yuji Maeda, Masami Taniguchi, Kunihiko Ikehara, Kazuo Akiyama   +15 more
doaj   +1 more source

Asthma: Cells involved in the pathophysiology of asthma

The Journal of Association of Chest Physicians, 2023
Asthma is a complex chronic inflammatory disease of the bronchioles characterized by airway hyperresponsiveness, bronchial hyperresponsiveness, and airway obstruction. Asthma is classified into various types.
Vivek Shinde, Pavankumar Wankhede, Neeraj Vyawahare   +2 more
doaj   +1 more source

気管支喘息症例における気道過敏性と鼻腔･副鼻腔疾患の関係に関する検討 [PDF]

, 1999
Pathological changes of nasosinus occur often in subjects with bronchial asthma. Coexisting nasosinus lesion may affect pathophysiology of lower respiratory tract in asthmatics.
Ashida, Kozo, Harada, Mine, Harada, Seishi, Hosaki, Yasuhiro, Mifune, Takashi, Mitsunobu, Fumihiro, Okamoto, Makoto, Takata, Shingo, Tanizaki, Yoshiro, Tsugeno, Hirofumi   +9 more
core   +1 more source

Clinical Characteristics of Geriatric Asthma in Guangxi of China: A Retrospective Comparative Descriptive Study

AGING MEDICINE, EarlyView.
Geriatric asthmatics exhibit more comorbidities, poorer lung function, higher neutrophil ratios, and elevated CRP levels. ABSTRACT Objective The research analyzed the clinical characteristics of geriatric and nongeriatric asthma cases, aiming to provide new insights into the diagnosis and management of geriatric asthma for clinicians.
Mengxia Gu, Qixiang Sun, Yujia Huang, Yuetian Deng, Xiaohong Jiang   +4 more
wiley   +1 more source

A Guinea Pig Model of Airway Smooth Muscle Hyperreactivity Induced by Chronic Allergic Lung Inflammation: Contribution of Epithelium and Oxidative Stress

Frontiers in Pharmacology, 2019
Asthma is a heterogeneous disease of the airways characterized by chronic inflammation associated with bronchial and smooth muscle hyperresponsiveness. Currently, different murine models for the study of asthma show poor bronchial hyperresponsiveness due
Luiz Henrique César Vasconcelos, Maria da Conceição Correia Silva, Alana Cristina Costa, Giuliana Amanda de Oliveira, Iara Leão Luna de Souza, Fernando Ramos Queiroga, Layanne Cabral da Cunha Araujo, Glêbia Alexa Cardoso, Renato Fraga Righetti, Renato Fraga Righetti, Alexandre Sérgio Silva, Alexandre Sérgio Silva, Patrícia Mirella da Silva, Patrícia Mirella da Silva, Carla Roberta de Oliveira Carvalho, Carla Roberta de Oliveira Carvalho, Giciane Carvalho Vieira, Iolanda de Fátima Lopes Calvo Tibério, Fabiana de Andrade Cavalcante, Fabiana de Andrade Cavalcante, Bagnólia Araújo da Silva, Bagnólia Araújo da Silva   +21 more
doaj   +1 more source

高齢者気管支喘息における喫煙による気道過敏性の亢進と温泉療法の臨床効果 [PDF]

, 2004
Clinical effects of spa therapy were examined in 60 elderly asthmatics in comparison between ex-smokers with a long history of cigarette smoking more than 20 years and never-smokers. Spa therapy wse effective in 47 of the 60 subjects (78.4%) with asthma.
Ashida, Kozo, Fujii, Makoto, Hamada, Masanori, Hosaki, Yasuhiro, Iwagaki, Naofumi, Mitsunobu, Fumihiro, Takata, Shingo, Tanizaki, Yoshiro   +7 more
core   +1 more source