Allergy, Volume 78, Issue 7, Page 1934-1948, July 2023., 2023 The effectiveness of anti‐IgE and anti‐IL5/5R was compared in this prospective cohort study including patients with severe asthma enrolled in ISAR and eligible for both biologic classes. Both anti‐IgE and anti‐IL5/5R improved asthma outcomes; however, anti‐IL5/5R was superior in reducing asthma exacerbations and LTOCS use.
Paul E. Pfeffer +68 more
wiley +1 more source
Precision Medicine in Targeted Therapies for Severe Asthma:Is There Any Place for "omics" Technology? [PDF]
, 2018 According to the current guidelines, severe asthma still represents a controversial topic in terms of definition and management. The introduction of novel biological therapies as a treatment option for severe asthmatic patients paved the way to a ...
Bertolini, Francesca +6 more
core +2 more sources
Diagnosis and management of eosinophilic asthma: a US perspective. [PDF]
, 2014 Eosinophilic asthma is now recognized as an important subphenotype of asthma based on the pattern of inflammatory cellular infiltrate in the airway. Eosinophilic asthma can be associated with increased asthma severity, atopy, late-onset disease, and ...
Doherty, Taylor A, Walford, Hannah H
core +1 more source
Regional ventilation changes in the lung: Treatment response mapping by using hyperpolarized gas MR imaging as a quantitative biomarker [PDF]
, 2017 Purpose: To assess the magnitude of regional response to respiratory therapeutics in the lungs using Treatment Response Mapping (TRM) with hyperpolarized gas MRI.
Brightling, C.E. +7 more
core +1 more source
Research highlights from the 2018 European Respiratory Society International Congress: Airway disease [PDF]
, 2010 The annual European Respiratory Society (ERS) International Congress (held in Paris in 2018) was once again a platform for discussion of the highest-quality scientific research, cutting-edge techniques and innovative new therapies within the respiratory ...
Andersson, Cecilia +6 more
core +1 more source
, 2023 Respirology, Volume 28, Issue 11, Page 986-988, November 2023.
Erin S. Harvey, Matthew J. Peters
wiley +1 more source
Bronchial thermoplasty: a novel technique in the treatment of severe asthma
Therapeutic Advances in Respiratory Disease, 2010 New therapies are needed for patients with severe persistent asthma who cannot achieve control with current therapy of inhaled corticosteroids and long-acting β 2 -agonists.
Mario Castro MD, MPH +3 more
doaj +1 more source
Bronchial thermoplasty: Redefining its role [PDF]
Respirology, 2020 ABSTRACTIn this review, we trace (i) the origins of bronchial thermoplasty, (ii) the development of a solid evidence base for efficacy and safety, (iii) the emerging understanding of the pathophysiological mechanisms of action and (iv) the place in therapy today. Future challenges are then discussed.
David Langton, Pyng Lee
openaire +2 more sources
Association between asthma control and bronchial hyperresponsiveness and airways inflammation: a cross-sectional study in daily practice. [PDF]
, 2009 Summary Background The primary end-point in the management of asthma is to obtain optimal control. The aim of this study was to assess the relationships between the markers of airway inflammation (sputum eosinophilia and exhaled nitric oxide), bronchial ...
Henket, Monique +3 more
core +1 more source
What is the role of bronchial thermoplasty in the management of severe asthma?
Therapeutic Advances in Respiratory Disease, 2018 Asthma is a common chronic inflammatory condition of the airways. Conventional therapy comprises inhaled corticosteroid and bronchodilators as well as trigger avoidance and management of comorbid conditions. A small group remain symptomatic despite these
Aoife O’Reilly, Stephen Lane
doaj +1 more source