MEPOLYP was a pooled analysis of 1037 patients with SAEP[±]CRSwNP. Mepolizumab was associated with a reduction in CSEs, OCS use, and BEC, and improved lung function and ACT score. Over 47% of patients fulfilled ≥ 3 clinical remission criteria. When compared, there was a 30.0% incremental benefit of mepolizumab in reducing CSEs for patients with SAEP ...
Florence Schleich+14 more
wiley +1 more source
Lung function, symptoms and inflammation during exacerbations of non-cystic fibrosis bronchiectasis: a prospective observational cohort study. [PDF]
Exacerbations of non-cystic fibrosis bronchiectasis cause significant morbidity but there are few detailed data on their clinical course and associated physiological changes.
Brill, SE+5 more
core
Multi-morbidities are Not a Driving Factor for an Increase of COPD-Related 30-Day Readmission Risk [PDF]
Background and Objective: Chronic obstructive pulmonary disease (COPD) is the third leading cause of death in the United States. COPD is expensive to treat, whereas the quality of care is difficult to evaluate due to the high prevalence of multi ...
Chukmaitov, Askar+3 more
core +1 more source
Mortality in young adults following in utero and childhood exposure to arsenic in drinking water. [PDF]
BackgroundBeginning in 1958, the city of Antofagasta in northern Chile was exposed to high arsenic concentrations (870 µg/L) when it switched water sources. The exposure abruptly stopped in 1970 when an arsenic-removal plant commenced operations.
Ferreccio, Catterina+5 more
core +1 more source
Effect of radiological extent and severity of bronchiectasis on pulmonary function
Background The aim of this study was to ascertain the effect of the extent and severity of bronchiectasis as determined with high-resolution computed tomography (HRCT) on lung function in patients with pure bronchiectasis, bronchiectasis and asthma, and ...
Habesoglu Mehmet A+3 more
doaj +1 more source
The microbiome in bronchiectasis [PDF]
Bronchiectasis is increasing in prevalence worldwide, yet current treatments available are limited to those alleviating symptoms and reducing exacerbations. The pathogenesis of the disease and the inflammatory, infective and molecular drivers of disease progression are not fully understood, making the development of novel treatments challenging ...
Richardson, Hollian+3 more
openaire +5 more sources
Radiological features of Distal Intestinal Obstruction Syndrome (DIOS): (A) Abdominal X‐ray (AXR) demonstrating limited sensitivity in diagnosing DIOS. (B) Coronal computed tomography (CT) confirming DIOS with characteristic findings of faecal loading, mural striation, and pericolonic fat stranding.
Chen Lew+6 more
wiley +1 more source
The diagnosis and treatment of elderly patients with acute exacerbation of chronic obstructive pulmonary disease and chronic bronchitis. [PDF]
The syndrome of chronic obstructive pulmonary disease (COPD) consists of chronic bronchitis (CB), bronchiectasis, emphysema, and reversible airway disease that combine uniquely in an individual patient.
Albertson, Timothy E+2 more
core
Risk factors for Haemophilus influenzae and pneumococcal respiratory tract colonization in CVID [PDF]
To the Editor: Disease-specific studies focused on infection risk in common variable immune deficiencies (CVIDs) are needed to define strategies for controlling respiratory infections predominantly due to bacteria such as Streptococcus pneumoniae and ...
Camilli, Romina+10 more
core +1 more source
Physiological Control of Realheart Total Artificial Heart
This study evaluates the Realheart Total Artificial Heart's preload‐based physiological controller, which dynamically adjusts heart rate and stroke volume to mimic the heart's natural responses during sleep, rest, and exercise using a hybrid mock circulation loop of the cardiovascular system.
Emanuele Perra+7 more
wiley +1 more source