Results 51 to 60 of about 66,208 (273)
Advanced Science, EarlyView.This study reveals a copper‐driven mechanism of COPD acute exacerbations mediated by the TNF‐α/ATP7A axis. TNF‐α suppresses the copper transporter ATP7A via competitive NF‐κB/CREB1/CBP signaling, resulting in intracellular copper accumulation, mitochondrial oxidative stress, and epithelial barrier disruption.
Xinru Xiao +7 more
wiley +1 more source
The Assessment of Vitamin D, Antimicrobial Peptides and Procalcitonin in Bronchiectasis [PDF]
, 2014 My research investigated the distribution of antimicrobial peptides (cathelicidin and β-defensin 2), vitamin D and the inflammatory marker procalcitonin, between systemic and localised respiratory levels in stable bronchiectasis patients.
Gartner, Sarah Nicole
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Arthritis &Rheumatology, EarlyView.Objective To characterize the clinical, immunologic, and proteomic changes associated with CD19 chimeric antigen receptor T cell therapy in patients with progressive systemic sclerosis (SSc). Methods Patients with progressive SSc received CD19 chimeric antigen receptor (CAR)‐T cell therapy and were observed longitudinally for safety, clinical efficacy,
Chenhan Jia +16 more
wiley +1 more source
Lung function, symptoms and inflammation during exacerbations of non-cystic fibrosis bronchiectasis: a prospective observational cohort study. [PDF]
, 2015 Exacerbations of non-cystic fibrosis bronchiectasis cause significant morbidity but there are few detailed data on their clinical course and associated physiological changes.
Hurst, JR +5 more
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Singing for children and adults with bronchiectasis [PDF]
This is a protocol for a Cochrane Review (Intervention). The objectives are as follows: To evaluate the effects of a singing program as an adjunctive therapy on the morbidity, respiratory muscles and pulmonary function of children and adults with ...
Irons, J.Y., Chang, A.B., Kenny, D.T.
core +1 more source
Immunity, Inflammation and Disease, 2022 Background Chronic rhinosinusitis affects 62% of adults with bronchiectasis and is linked to greater bronchiectasis severity. However, the impact of symptoms of chronic rhinosinusitis on disease‐specific and cough‐related quality of life is unknown ...
Annemarie L. Lee +6 more
doaj +1 more source
Arthritis &Rheumatology, Accepted Article.Objective We evaluated baseline characteristics, treatment patterns, and outcomes in patients with systemic autoimmune rheumatic disease‐associated progressive pulmonary fibrosis (SARD‐PPF) and evaluated whether outcomes differed by SARD subtype. Methods The ILD‐PRO Registry is a prospective multicenter US registry of patients with PPF.
Sonali J Bracken +7 more
wiley +1 more source
Chronic Diseases and Translational Medicine, 2017 Objective: To investigate the presence of previously undiagnosed radiographic bronchiectasis in stable chronic obstructive pulmonary disease (COPD) patients using high resolution computed tomography (HRCT) and to evaluate the effect of radiographic ...
Rong-Bao Zhang +3 more
doaj +1 more source
Cancer in Systemic Sclerosis: Clinical Associations and Prognostic Impact From the EUSTAR Registry
Arthritis &Rheumatology, EarlyView.Objective Cancer represents a major cause of death in systemic sclerosis (SSc). Established risk factors are limited to specific subsets, particularly early diffuse anti‐RNA polymerase III (POLR3)–positive disease, needing further exploration. Methods We performed a nested case‐control study within the European Scleroderma Trials and Research group ...
Antonio Tonutti +52 more
wiley +1 more source
EpigeneticsThis study aims to discover drug targeted genes and explore the potential epigenetics mechanisms in bronchiectasis. Cis-expression quantitative trait locus (eQTL) was obtained as exposure, and bronchiectasis from the FinnGen cohort was used as outcome ...
Jiangyue Qin +7 more
doaj +1 more source