Results 51 to 60 of about 51,706 (265)

Genome sequencing reveals underdiagnosis of primary ciliary dyskinesia in bronchiectasis

European Respiratory Journal, 2022
Background Bronchiectasis can result from infectious, genetic, immunological and allergic causes. 60–80% of cases are idiopathic, but a well-recognised genetic cause is the motile ciliopathy, primary ciliary dyskinesia (PCD).
A. Shoemark, Helen Griffin, G. Wheway, C. Hogg, J. Lucas, C. Camps, Jenny C. Taylor, M. Carroll, M. Loebinger, J. Chalmers, D. Morris-Rosendahl, H. Mitchison, A. De Soyza, D. J.C. P. R. M. F. C.R. H. M.J. G.C. T. A. A. S. T.J Brown Ambrose Arumugam Bevers Bleda Boardman-Prett   +13 more
semanticscholar   +1 more source

DNA methylation and bronchiectasis: a Mendelian randomization analysis to investigate causal link and therapeutic target

Epigenetics
This study aims to discover drug targeted genes and explore the potential epigenetics mechanisms in bronchiectasis. Cis-expression quantitative trait locus (eQTL) was obtained as exposure, and bronchiectasis from the FinnGen cohort was used as outcome ...
Jiangyue Qin, Bi Ran, Lian Liu, Ping Li, Zhenni Chen, Diandian Li, Yongchun Shen, Fuqiang Wen   +7 more
doaj   +1 more source

Common variable immunodeficiency disorder - An uncommon cause for bronchiectasis

Lung India, 2014
Bronchiectasis continues to be a common respiratory problem of varied etiology. Common variable immunodeficiency disorder (CVID) is an uncommon cause for bronchiectasis.
Manoj Kumar Panigrahi
doaj   +1 more source

Integrated Clinical and Proteomic Profiling of CD19 Chimeric Antigen Receptor T Cell Therapy in Progressive Systemic Sclerosis

Arthritis &Rheumatology, EarlyView.
Objective To characterize the clinical, immunologic, and proteomic changes associated with CD19 chimeric antigen receptor T cell therapy in patients with progressive systemic sclerosis (SSc). Methods Patients with progressive SSc received CD19 chimeric antigen receptor (CAR)‐T cell therapy and were observed longitudinally for safety, clinical efficacy,
Chenhan Jia, Wanyi Lin, Zhangyi Zhao, Fenglin Wu, Chaoyu Gu, Yuankai Sun, Zhe Ding, Chang Wei, Xinyu Li, Cuiwei Xie, Peng Xia, Zhen Xia, Xuesong Liu, Shaoying Yang, Chunyan Zhang, Hanlin Yin, Liangjing Lu   +16 more
wiley   +1 more source

Phase 2 Trial of the DPP-1 Inhibitor Brensocatib in Bronchiectasis.

New England Journal of Medicine, 2020
BACKGROUND Patients with bronchiectasis have frequent exacerbations that are thought to be related to neutrophilic inflammation. The activity and quantity of neutrophil serine proteases, including neutrophil elastase, are increased in the sputum of ...
J. Chalmers, C. Haworth, M. Metersky, M. Loebinger, F. Blasi, O. Sibila, A. O'donnell, E. Sullivan, K. Mange, Carlos Fernandez, Jun Zou, C. Daley   +11 more
semanticscholar   +1 more source

Bronchiectasis exacerbation: a narrative review of causes, risk factors, management and prevention

Annals of Translational Medicine, 2022
Background and Objective Bronchiectasis exacerbations are significant events in the natural course of the disease and determine long-term clinical outcomes.
Hayoung Choi, J. Chalmers
semanticscholar   +1 more source

Pathophysiology and genomics of bronchiectasis

European Respiratory Review
Bronchiectasis is a complex and heterogeneous inflammatory chronic respiratory disease with an unknown cause in around 30–40% of patients. The presence of airway infection together with chronic inflammation, airway mucociliary dysfunction and lung damage
Lidia Perea, R. Faner, James D. Chalmers, O. Sibila   +3 more
semanticscholar   +1 more source

Paediatric development of radiopharmaceutical imaging agents and radioligand therapeutics

British Journal of Clinical Pharmacology, EarlyView.
Abstract This review focuses on the development of radiopharmaceutical imaging agents and radioligand therapeutics for paediatric use. Nuclear medicine plays an important role in the diagnosis and treatment of various childhood conditions, including cancers, infections and brain disorders.
Justin L. Hay, Amandine Manon, Hunter Stephens, S. Y. Amy Cheung, Bart de Keizer, Erik T. te Beek   +5 more
wiley   +1 more source

Medical Causes of Hospitalisation among Patients with Bronchiectasis: A Nationwide Study in Japan

Pathogens
Purpose: Although the international guidelines for managing bronchiectasis are centred on preventing the exacerbation of bronchiectasis, the medical causes of admissions to hospital among patients with bronchiectasis have not been fully investigated ...
Akihiko Hagiwara, Hisayuki Shuto, Ryohei Kudoh, Shota Omori, Kazufumi Hiramatsu, Jun-ichi Kadota, Kiyohide Fushimi, Kosaku Komiya   +7 more
doaj   +1 more source

Exacerbations of bronchiectasis

European Respiratory Review
Bronchiectasis presents a significant challenge due to its rising prevalence, associated economic burden and clinical heterogeneity. This review synthesises contemporary understanding and literature of bronchiectasis exacerbations, addressing the ...
Alessandro De Angelis, Emma D. Johnson, S. Sutharsan, S. Aliberti   +3 more
semanticscholar   +1 more source