Results 41 to 50 of about 51,706 (265)

The clinical impact of self‐reported symptoms of chronic rhinosinusitis in people with bronchiectasis

Immunity, Inflammation and Disease, 2022
Background Chronic rhinosinusitis affects 62% of adults with bronchiectasis and is linked to greater bronchiectasis severity. However, the impact of symptoms of chronic rhinosinusitis on disease‐specific and cough‐related quality of life is unknown ...
Annemarie L. Lee, Caroline H. H. Nicolson, Janet Bondarenko, Brenda M. Button, Samantha Ellis, Robert G. Stirling, Mark Hew   +6 more
doaj   +1 more source

Microbial Dysregulation of the Gut-Lung Axis in Bronchiectasis

American Journal of Respiratory and Critical Care Medicine, 2022
Rationale Emerging data support the existence of a microbial “gut-lung” axis that remains unexplored in bronchiectasis. Methods Prospective and concurrent sampling of gut (stool) and lung (sputum) was performed in a cohort of n = 57 individuals with ...
J. Narayana, S. Aliberti, Micheál Mac Aogáin, T. Jaggi, Nur A'tikah Binte Mohamed Ali, F. Xaverius Ivan, H. Cheng, Y. Yip, Marcus Ivan Gerard Vos, Zun Siong Low, J. X. T. Lee, F. Amati, A. Gramegna, S. Wong, J. Sung, N. Tan, K. Tsaneva-Atanasova, F. Blasi, S. Chotirmall   +18 more
semanticscholar   +1 more source

Cathepsin C (dipeptidyl peptidase 1) inhibition in adults with bronchiectasis: AIRLEAF, a phase II randomised, double-blind, placebo-controlled, dose-finding study

European Respiratory Journal
Graphical abstract Overview of key study findings. 1) A significant dose-dependent benefit of BI 1291583 over placebo was established based on time to first exacerbation up to week 48.
James D. Chalmers, M. Shteinberg, M. Mall, A. O’Donnell, H. Watz, Abhya Gupta, E. Frahm, A. Eleftheraki, J. Rauch, S. Chotirmall, A. Armstrong, P. Eickholz, N. Hasegawa, W. Sauter, P. Mcshane   +14 more
semanticscholar   +1 more source

The sputum microbiome and clinical outcomes in patients with bronchiectasis: a prospective observational study.

The Lancet Respiratory Medicine, 2021
BACKGROUND Infection is a key component of bronchiectasis pathophysiology. Characterisation of the microbiome offers a higher degree of sensitivity and resolution than does traditional culture methods.
A. Dicker, M. Lonergan, Holly R. Keir, Alexandria H Smith, J. Pollock, S. Finch, A. Cassidy, J. Huang, J. Chalmers   +8 more
semanticscholar   +1 more source

Marked Long‐Term Improvement in Lung Function in Melanoma Differentiation–Associated Protein 5 Antibody–Positive Dermatomyositis Patients: Experience of a Single‐Center Longitudinal Cohort in North America

Arthritis Care &Research, EarlyView.
Objective The objective of this study was to describe the longitudinal disease course and pulmonary outcomes of North American patients with melanoma differentiation–associated protein 5 (MDA5) antibody–associated dermatomyositis (DM). Methods Thirty patients with MDA5 antibody–associated DM were identified in a single‐center longitudinal cohort of 352
Jenice X. Cheah, Sangmee S. Bae, Tiffany De Leon, Yuna Lee, Rong Guo, David Elashoff, Jennifer Wang, Ani Shahbazian, Christina Charles‐Schoeman   +8 more
wiley   +1 more source

Bronchiectasis management in adults: state of the art and future directions

European Respiratory Journal
Formerly regarded as a rare disease, bronchiectasis is increasingly recognised. A renewed interest in this disease has led to significant progress in bronchiectasis research.
Hayoung Choi, P. McShane, S. Aliberti, James D. Chalmers   +3 more
semanticscholar   +1 more source

Clinical outcomes of bronchiectasis in India: data from the EMBARC/Respiratory Research Network of India registry

European Respiratory Journal, 2022
Background Identifying risk factors for poor outcomes can help with risk stratification and targeting of treatment. Risk factors for mortality and exacerbations have been identified in bronchiectasis but have been almost exclusively studied in European ...
R. Dhar, Sheetu Singh, D. Talwar, B.V. Murali Mohan, Suryakant Tripathi, R. Swarnakar, Sonali Trivedi, S. Rajagopala, G. D'Souza, Arjun Padmanabhan, B. Archana, P. Mahesh, B. Ghewade, Girija Nair, A. Jindal, G. D. Jayadevappa, Honney Sawhney, K. Sarmah, K. Saha, Suresh Anantharaj, A. Khanna, Samir Gami, Arti Shah, Arpan Shah, N. Dutt, Himanshu Garg, S. Vyas, K. Venugopal, R. Prasad, N. M. Aleemuddin, S. Karmakar, Virendra Singh, S. Jindal, Shubham Sharma, D. Prajapat, Sagar Chandrashekar, M. Loebinger, Aditi Mishra, F. Blasi, R. Ramanathan, P. Goeminne, Preethi Vasudev, A. Shoemark, B. Jayaraj, Rahul Kungwani, Akanksha Das, Mehneet Sawhney, E. Polverino, T. Welte, Nayan Sri Gulecha, M. Shteinberg, A. Mangala, Palak Shah, N. Chauhan, Nikita Jajodia, Ashutosh Singhal, S. Batra, A. Hasan, S. Aliberti, M. Crichton, S. Limaye, S. Salvi, J. Chalmers   +62 more
semanticscholar   +1 more source

Human Urine Stem Cells Alleviate Pulmonary Fibrosis via Inhibiting Macrophage‐Myofibroblast Transition

Advanced Science, EarlyView.
Therapeutic role and mechanism of human urine stem cells (hUSCs) in pulmonary fibrosis. hUSCs alleviated pulmonary fibrosis by selectively inhibiting macrophage‐myofibroblast transition (MMT) in two ways: on one hand, hUSCs inhibited mitochondrial reactive oxygen species (mtROS) production and apoptosis/senescence of epithelial cells in pulmonary ...
Zhou‐Hang Zhang, Guan‐Lin Guo, Xiao‐Hui Guan, Min Hu, Qi‐Ming Huang, Ding‐Wen Guo, Hao‐Cheng Gu, You‐Qiong Zhuo, Ning Li, Hong‐Bo Xin, Ke‐Yu Deng   +10 more
wiley   +1 more source

Increasing prevalence and burden of bronchiectasis in urban Chinese adults, 2013–2017: a nationwide population-based cohort study

Respiratory Research, 2022
Background While the prevalence and disease burden of bronchiectasis are increasing, data in the world’s largest population are lacking. We aimed to investigate the prevalence and disease burden of bronchiectasis in Chinese adults. Methods We conducted a
Jingnan Feng, Lina Sun, Xiaoyan Sun, Lu Xu, Lili Liu, Guozhen Liu, Jinxi Wang, Pei-Rong Gao, S. Zhan, Yahong Chen, Shengfeng Wang, Yongchang Sun   +11 more
semanticscholar   +1 more source

Evaluation of symptoms and risks in stable chronic obstructive pulmonary disease patients with radiographic bronchiectasis

Chronic Diseases and Translational Medicine, 2017
Objective: To investigate the presence of previously undiagnosed radiographic bronchiectasis in stable chronic obstructive pulmonary disease (COPD) patients using high resolution computed tomography (HRCT) and to evaluate the effect of radiographic ...
Rong-Bao Zhang, Fei Yuan, Xing-Yu Tan, Quan-Ying He   +3 more
doaj   +1 more source