Results 61 to 70 of about 51,706 (265)

Preserved Spermatogenesis and Hormonal Function in Men Receiving a Pretomanid Regimen (BPaMZ) for Pulmonary Drug‐Resistant Tuberculosis

Clinical Pharmacology &Therapeutics, EarlyView.
Pretomanid is a component of the World Health Organization‐recommended treatment regimen for drug‐resistant tuberculosis in patients aged ≥ 14 years. While preclinical rodent studies identified testicular toxicity as a potential clinical liability at elevated doses, no corresponding effects were observed in nonhuman primates nor clinical hormone ...
Pauline Howell, Antonio Lombardi, William Brumskine, Lali Mikiashvili, Kim Boekelheide, Joanna Moreira, Alda Holsta, Matthew Betteridge, Lindsay Thompson, Angela Crook, Paul Bruinenberg, Maria Beumont, Eugene Sun, Francesca Conradie   +13 more
wiley   +1 more source

Clinical characteristics and outcome of non-cystic fibrosis bronchiectasis in children: A tertiary care perspective

SAGE Open Medicine
Introduction: Bronchiectasis is a chronic respiratory disease caused by various respiratory and systemic conditions. It is now considered a potentially reversible disease, particularly when diagnosed early and managed with appropriate respiratory care ...
Phanthila Sitthikarnkha, Apichaya Anekvorakul, Sirapoom Niamsanit, Leelawadee Techasatian, Suchaorn Saengnipanthkul, Rattapon Uppala   +5 more
doaj   +1 more source

Gastro-oesophageal reflux disease increases healthcare use and medical costs in patients with bronchiectasis: a Korean nationwide population-based study

Therapeutic Advances in Gastroenterology, 2021
Background: Gastro-oesophageal reflux disease (GORD) is not only a common aetiology but also accompanying comorbidity of non-cystic fibrosis bronchiectasis (bronchiectasis).
Jai Hoon Yoon, Sang Hyuk Kim, Jiin Ryu, Sung Jun Chung, Youlim Kim, Chang Ki Yoon, Seung Won Ra, Yeon Mok Oh, Hayoung Choi, Hyun Lee   +9 more
doaj   +1 more source

Novel Organelle‐Based Intracellular Immunity With Mechanistic and Therapeutic Implications

Barrier Immunity, EarlyView.
A conceptual framework illustrating how PAMPs/DAMPs initiate barrier, innate, adaptive, and intracellular immune responses, with organelle‐based intracellular immunity serving as a central integrator linking metabolism, inflammatory signaling, and therapeutic interventions to restore immune homeostasis.
Keman Xu, Shih‐Yu Hung, Fatma Saaoud, Ying Shao, Yifan Lu, Juanjuan Liu, Bo Yuan, Haiyan Xiang, Hong Wang, Xiaofeng Yang   +9 more
wiley   +1 more source

Characteristics of Patients with Idiopathic Bronchiectasis in Comparison to Post-infectious Bronchiectasis in South Korea [PDF]

Tuberculosis and Respiratory Diseases
Background Bronchiectasis has a complex and heterogeneous pathogenesis, with various etiologies, the majority being idiopathic. This study aimed to examine the characteristics of patients with idiopathic bronchiectasis in comparison to those with post ...
Seo-Young Hwang, Hyun Lee, Hayoung Choi, Seung Won Ra, Yeon-Mok Oh,   +5 more
doaj   +1 more source

High‐Throughput Geocoding to Assess Short‐Term Air Pollution in Correlation With Mortality in a French Cancer Patient Cohort

International Journal of Cancer, EarlyView.
Although chronic air pollution exposure is linked to lung cancer mortality, the short‐term effects of fluctuating air quality on overall cancer mortality remain uncertain. Here, the authors applied geomatics and machine‐learning models to retrospectively examine possible associations between 31‐day pollution exposure and mortality in a French cancer ...
Loice Pokam, Joséphine Bocquet, Nadia Hégarat, Julie Perlbarg‐Samson, Thomas Balezeau, Maud Milder, Bastien Rance, Hector Countouris, Julien Guerin, Flavien Gilles, Jean Gaudart, Nicolas Girard, Clémence Basse   +12 more
wiley   +1 more source

The Efficacy and Safety of Inhaled Antibiotics for the Treatment of Bronchiectasis in Adults

Chest
Background Inhaled antibiotics are recommended conditionally by international bronchiectasis guidelines for the treatment of patients with bronchiectasis, but results of individual studies are inconsistent. A previous meta-analysis demonstrated promising
R. Cordeiro, Hayoung Choi, C. Haworth, James D. Chalmers   +3 more
semanticscholar   +1 more source

Comparison of Retrospective Motion Compensation Techniques for Pulmonary Dynamic Ultrashort Time to Echo MRI in Suspected Idiopathic Pulmonary Fibrosis

Journal of Magnetic Resonance Imaging, EarlyView.
ABSTRACT Background Motion can degrade image quality during Ultrashort Time‐to‐Echo (UTE) pulmonary MRI and is particularly prevalent in patients with lung disease. Comprehensive assessment of the impact of motion compensation techniques on image quality and clinical interpretation is needed.
Abhilash S. Kizhakke Puliyakote, Luis A. Torres, Aiah AlAtoum, Natally AlArab, Kevin M. Johnson, Rodrigo M. Bello, Bryan O'Sullivan‐Murphy, Joseph G. Mammarappallil, Andrew D. Hahn, Sean B. Fain   +9 more
wiley   +1 more source

Secondary Immunodeficiency and Non-cystic Fibrosis Bronchiectasis [PDF]

Tuberculosis and Respiratory Diseases
Bronchiectasis is a chronic respiratory disease characterized by abnormal dilation of the bronchi that causes cough, sputum, and recurrent infections. As it may be associated with various respiratory or systemic diseases, a critical aspect of managing ...
Sungmin Zo, Ji-Yong Moon, Kyung Hoon Min, Hyun Lee   +3 more
doaj   +1 more source

Mucolytics for bronchiectasis [PDF]

Cochrane Database of Systematic Reviews, 2014
Bronchiectasis is predominantly an acquired disease process that represents the end stage of a variety of unrelated pulmonary insults. It is defined as persistent irreversible dilatation and distortion of medium-sized bronchi. It has been suggested that with widespread use of high-resolution computed tomography, more bronchiectasis diagnoses are being ...
Wilkinson, M., Sugumar, K., Milan, S., Hart, A., Crockett, A., Crossingham, I.   +5 more
openaire   +3 more sources