Results 61 to 70 of about 80,333 (208)

The diagnosis and treatment of elderly patients with acute exacerbation of chronic obstructive pulmonary disease and chronic bronchitis. [PDF]

, 2010
The syndrome of chronic obstructive pulmonary disease (COPD) consists of chronic bronchitis (CB), bronchiectasis, emphysema, and reversible airway disease that combine uniquely in an individual patient.
Albertson, Timothy E, Chan, Andrew L, Louie, Samuel   +2 more
core  

Early clinical pharmacology evaluation of the novel anti‐inflammatory macrolide, glasmacinal (EP395): tolerability, pharmacokinetics and drug interactions

British Journal of Clinical Pharmacology, EarlyView.
Abstract Aims This work assessed the pharmacokinetics (PK), safety and tolerability of glasmacinal (EP395, an oral anti‐inflammatory macrolide with negligible antimicrobial activity in development for COPD treatment) in two healthy participant trials: ‘first‐in‐human’ (FIH) and ‘drug–drug‐interaction’ (DDI).
Dave Singh, Kate Hanrott, Olof Breuer, Johan Bylund, Björn Schultze, Virginia Norris   +5 more
wiley   +1 more source

Gastro-oesophageal reflux disease increases healthcare use and medical costs in patients with bronchiectasis: a Korean nationwide population-based study

Therapeutic Advances in Gastroenterology, 2021
Background: Gastro-oesophageal reflux disease (GORD) is not only a common aetiology but also accompanying comorbidity of non-cystic fibrosis bronchiectasis (bronchiectasis).
Jai Hoon Yoon, Sang Hyuk Kim, Jiin Ryu, Sung Jun Chung, Youlim Kim, Chang Ki Yoon, Seung Won Ra, Yeon Mok Oh, Hayoung Choi, Hyun Lee   +9 more
doaj   +1 more source

Management of Children With Chronic Wet Cough and Protracted Bacterial Bronchitis CHEST Guideline and Expert Panel Report [PDF]

, 2017
BACKGROUND: Wet or productive cough is common in children with chronic cough. We formulated recommendations based on systematic reviews related to the management of chronic wet cough in children (aged METHODS: We used the CHEST expert cough panel\u27s ...
Chang, Anne B., CHEST Expert Cough Panel, Grant, Cameron C., Irwin, Richard S., Oppenheimer, John J., Rubin, Bruce K., Weinberger, Miles M., Weir, Kelly   +7 more
core   +2 more sources

Novel Organelle‐Based Intracellular Immunity With Mechanistic and Therapeutic Implications

Barrier Immunity, EarlyView.
A conceptual framework illustrating how PAMPs/DAMPs initiate barrier, innate, adaptive, and intracellular immune responses, with organelle‐based intracellular immunity serving as a central integrator linking metabolism, inflammatory signaling, and therapeutic interventions to restore immune homeostasis.
Keman Xu, Shih‐Yu Hung, Fatma Saaoud, Ying Shao, Yifan Lu, Juanjuan Liu, Bo Yuan, Haiyan Xiang, Hong Wang, Xiaofeng Yang   +9 more
wiley   +1 more source

Secondary Immunodeficiency and Non-cystic Fibrosis Bronchiectasis [PDF]

Tuberculosis and Respiratory Diseases
Bronchiectasis is a chronic respiratory disease characterized by abnormal dilation of the bronchi that causes cough, sputum, and recurrent infections. As it may be associated with various respiratory or systemic diseases, a critical aspect of managing ...
Sungmin Zo, Ji-Yong Moon, Kyung Hoon Min, Hyun Lee   +3 more
doaj   +1 more source

Lung function, symptoms and inflammation during exacerbations of non-cystic fibrosis bronchiectasis: a prospective observational cohort study. [PDF]

, 2015
Exacerbations of non-cystic fibrosis bronchiectasis cause significant morbidity but there are few detailed data on their clinical course and associated physiological changes.
Brill, SE, Brown, JS, Hurst, JR, Mackay, AJ, Patel, AR, Singh, R   +5 more
core  

The development of bronchiectasis on chest computed tomography in children with cystic fibrosis: can pre-stages be identified? [PDF]

, 2016
Objective: Bronchiectasis is an important component of cystic fibrosis (CF) lung disease but little is known about its development. We aimed to study the development of bronchiectasis and identify determinants for rapid progression of bronchiectasis on ...
Bruijne, M. (Marleen) de, Caudri, D. (Daan), Perez-Rovira, A. (Adria), Tepper, L.A. (Leonie), Tiddens, H.A.W.M. (Harm)   +4 more
core   +4 more sources

A large‐scale single‐cell transcriptomic atlas indicates the immune panorama of influenza A infection

iMeta, EarlyView.
The study presents a large‐scale single‐cell transcriptomic atlas profiling over 612,010 peripheral immune cells from 97 individuals to decode the heterogeneity of influenza infection. These findings indicate a fundamental immune dichotomy determining clinical trajectories: a protective, monocyte‐centric antiviral state in mild disease versus a ...
Yi Wang, Shuzi Liu, Laurence Don Wai Luu, Yongzhi Zhai, Chenliang Zhu, Zhaomin Feng, Yao Tan, Linglong Wan, Jie Wang, Juan Zhou, Jing Wang, Lixin Xie, Quanyi Wang, Fei Xie   +13 more
wiley   +1 more source

Bronchial Mucosal Abnormalities in Idiopathic Subglottic Stenosis

The Laryngoscope, EarlyView.
Idiopathic subglottic stenosis (iSGS) is a challenging variant of airway stenosis associated with consistent distal airway abnormalities on bronchoscopy, including pits, depressions, and striations. Despite these findings, most patients demonstrate normal or mild–moderate obstruction on spirometry.
Sydney Ring, Andrew Jay Bowen, Tessa Griffin, J. Scott Ferguson, Seth H. Dailey   +4 more
wiley   +1 more source