Results 251 to 260 of about 132,728 (352)

Myofibroblast‐Derived Extracellular Vesicles Drive Profibrotic Cascade Amplification in Pulmonary Fibrosis via the Nestin‐Rab7 Axis

Journal of Extracellular Vesicles, Volume 15, Issue 1, January 2026.
ABSTRACT Idiopathic pulmonary fibrosis (IPF) is a fatal fibrotic lung disease characterized by aberrant myofibroblast activation and excessive extracellular matrix deposition, with extracellular vesicles (EVs) playing a crucial role in this pathological process. We observed that EVs levels are significantly elevated in IPF and positively correlate with
Xiaofan Lai, Yong Xiao, Yingying Lin, Senyu Yao, Bin Wang, Hainan Chen, Tianxiang Lei, Shaojie Huang, Chenxing Lei, Qihao Zeng, Yuan Qiu, Hong Chen, Tao Wang, Jiancheng Wang, Andy Peng Xiang   +14 more
wiley   +1 more source

CXCR3/CXCL10 Axis‐Mediated T Cell Infiltration in the Lungs of Patients With HTLV‐1‐Associated Diseases: Implications for Subclinical Pulmonary Involvement

Journal of Medical Virology, Volume 98, Issue 1, January 2026.
Abstract HTLV‐1 is a retrovirus associated with adult T cell leukemia/lymphoma (ATL) and inflammatory diseases, including HTLV‐1‐associated myelopathy (HAM) and HTLV‐1‐associated bronchopneumonopathy (HAB). Although pulmonary complications are common in HTLV‐1‐associated diseases, the underlying mechanisms remain unclear.
Kanako Tsuchimoto, Ayasa Mori, Masakazu Tanaka, Shiho Arishima, Daisuke Kodama, Mika Dozono, Satoshi Nozuma, Hiroshi Takashima, Ryuji Kubota   +8 more
wiley   +1 more source

CD4/CD8 T-cell ratio in bronchoalveolar lavage fluid as a marker of sarcoidosis severity: a retrospective study. [PDF]

BMC Pulm Med
Zannese T, Viallard JF, Sridi-Cheniti S, Prot-Leurent C, Dupuy H, Léonard C, Duffau P, Lazaro E, Greib C, Rivière E.   +9 more
europepmc   +1 more source

Alveolar Extracellular Vesicles May Protect Some Patients With Chronic Aspiration From Pneumonia

The Laryngoscope, Volume 136, Issue 1, Page 134-142, January 2026.
A subset of patients with chronic aspiration appear to be relatively protected against pneumonias. This prospective observational study examines the alveolar fluid of patients with chronic aspiration with and without pneumonia. We found relatively little difference in classical cytokine levels but a difference in both the level and protein composition ...
James T. Ross, Nina W. Zhao, Dino Petrov, Ching‐Wen Lin, Alyssa Bellini, Neona Lowe, Bryan Nguyen, Dustin Hadley, Randy P. Carney, Anamaria J. Robles, Rachael A. Callcut, Peter C. Belafsky   +11 more
wiley   +1 more source

Application value of metagenomic next-generation sequencing of bronchoalveolar lavage fluid in pathogen detection and diagnostic efficiency of acute exacerbation of bronchiectasis. [PDF]

Am J Transl Res
He Z, Kong J, Su Q, Lin J.
europepmc   +1 more source

Emestrin‐Type Epidithiodiketopiperazines Inhibited Gasdermin D‐Mediated Pyroptosis via Caspase‐3/7 Activation

MedComm, Volume 7, Issue 1, January 2026.
This study demonstrates that emestrin‐type ETPs suppress GSDMD‐mediated pyroptosis through caspase‐3/7 activation, thereby attenuating inflammatory responses and conferring protection against sepsis. In THP‐1 macrophages, ETPs significantly reduced pyroptosis and secretion of the proinflammatory cytokines IL‐1β and IL‐18.
Bingchuan Geng, Shuang Lin, Wai Yen Yim, Weiguang Sun, Xiaotian Zhang, Cao Ma, Zhiwen Zhang, Quan Guo, Jie Gao, Hanxiao Zeng, Qingyi Tong, Yixuan Wang, Zhengfeng Fan, Jincheng Hou, Muwei Li, Yonghui Zhang, Zhengxi Hu   +16 more
wiley   +1 more source

Application of Metagenomic and Targeted Next-Generation Sequencing in Diagnosis of Pulmonary Tuberculosis in Bronchoalveolar Lavage Fluid. [PDF]

Infect Drug Resist
Yang Z, Liu Q, Hu Y, Geng S, Ni JX.
europepmc   +1 more source

Wnt Signaling Pathway: Biological Function, Diseases, and Therapeutic Interventions

MedComm, Volume 7, Issue 1, January 2026.
The Wnt signaling pathway is essential for development and tissue homeostasis, while its dysregulation drives diverse diseases. This review systematically outlines its components, functions, regulators, and preclinical models, highlighting secreted frizzled‐related proteins (SFRPs) as context‐dependent, biphasic modulators.
Xiaoyu Jin, Jiahui Wang, Runyi Cao, Dongsheng Jiang   +3 more
wiley   +1 more source

Development and validation of a LC-MS/MS method for the simultaneous determination of simnotrelvir and ritonavir in human serum and bronchoalveolar lavage fluid. [PDF]

BMC Chem
Yang X, Lin W, Zhao Y, Zhao C, Zhou F, Wang D, Yue Z, Pei L, Jia M, Cao B, Cao LL, Wang H.   +11 more
europepmc   +1 more source

Clinical Application Value of Simultaneous Plasma and Bronchoalveolar Lavage Fluid Metagenomic Next Generation Sequencing in Patients with Pneumonia-Derived Sepsis

Jiayan Li, Dongxu Pan, Yuxin Guo, Bo Zhang, Xinglin Lu, Chen Deng, Feifei Xu, Zongnan Lv, Qinhe Chen, Yafeng Zheng, Shuhao Nong, Lihua Su, Rongfa Qin, Fufu Jiang, Wei Gai, Gang Qin   +15 more
openalex   +1 more source