Results 61 to 70 of about 110,976 (348)

Inhaled Interleukin-10 before and after induction of experimental endotoxemia in the rat : effects on the inflammatory response [PDF]

, 2007
To determine the effects of inhaled IL-10 at different doses and different time points on the pulmonary and systemic inflammatory response during endotoxemia, 48 ventilated, anaesthetized rats (mean body weight ± standard deviation, 500 ± 33g) were ...
Nguyen, Ngoc-Thach
core  

Biomarker-guided antibiotic stewardship in suspected ventilator-associated pneumonia (VAPrapid2) : a randomised controlled trial and process evaluation [PDF]

, 2019
Background Ventilator-associated pneumonia is the most common intensive care unit (ICU)-acquired infection, yet accurate diagnosis remains difficult, leading to overuse of antibiotics. Low concentrations of IL-1β and IL-8 in bronchoalveolar lavage fluid
Agus, Ashley M., Allen, Joy, Anderson, Niall, Bannard-Smith, Jonathan, Bassford, Christopher, Baudouin, Simon V., Blackwood, Bronagh, Bonner, Stephen, Boschman, Gert, Bowett, Susan, Conway Morris, Andrew, Dark, Paul, Emerson, Lydia M., Hellyer, Thomas P., Hulme, Jonathan, Keenan, James, Kefala, Kallirroi, Laha, Shondipon K., Linnett, Vanessa, McAuley, Daniel F., McMullan, Ronan, O’Kane, Cecilia M., Parker, Jennie, Paterson, Ross L., Perkins, Gavin D., Phair, Glenn, Robin, Nicole M., Rostron, Anthony J., Roy, Alistair I., Scott, Jonathan, Simpson, John, Singh, Suveer, Sonksen, Julian, Spencer, Craig, Van Den Broeck, Tina, Walsh, Timothy S., Welters, Ingeborg D., Wright, Stephen E., Yates, Bryan   +38 more
core   +6 more sources

Pulmonary Delivery of siRNA Anti‐TNFα‐loaded Lipid Nanoparticles for Rapid Recovery in Murine Acute Lung Injury

Advanced Healthcare Materials, EarlyView.
In a murine model of acute lung injury, pulmonary administration of lipid nanoparticles carrying TNFα siRNA enables targeted delivery to immune cells. The study emphasises the importance of optimizing LNP distribution and delivery timing to improve therapeutic outcomes and develop emergency therapies for lung hyperinflammation.
Qinglin Wang, Jihana Achour, Laila Emam, Younes Louaguenouni, Catherine Cailleau, Françoise Mercier‐Nomé, Séverine Domenichini, Claudine Delomenie, Sezen Gul, Juliette Vergnaud, Nicolas Tsapis, Arnaud Mansart, Djillali Annane, Francois Fay, Elias Fattal   +14 more
wiley   +1 more source

Phospholipid composition and kinetics in different endobronchial fractions from healthy volunteers [PDF]

, 2014
Tracheal secretions may be of value as a surrogate to assess bronchoalveolar lavage fluid surfactant molecular composition and metabolism in healthy people.
Cusack, Rebecca, Dushianthan, Ahilanandan, Goss, Victoria, Grocott, Michael P.W., Postle, Anthony D.   +4 more
core   +1 more source

Advanced Nanoparticle Therapeutics for Targeting Neutrophils in Inflammatory Diseases

Advanced Healthcare Materials, EarlyView.
This review highlights recent advances in nanoparticle‐based strategies to modulate neutrophil activity in inflammatory diseases. By targeting inflammatory neutrophils, NET formation, and neutrophil apoptosis or recruitment, these approaches aim to improve therapeutic precision.
Min Ji Byun, Elizabeth S. Nakasone, Ha Eun Shin, Hyojin Lee, Jong‐Chan Park, Wonhwa Lee, Wooram Park, Chun Gwon Park, Juwon Park, Se‐Na Kim   +9 more
wiley   +1 more source

Kinetics of microRNA Expression in Bronchoalveolar Lavage Fluid Samples [PDF]

Lung, 2015
Levels of microRNAs (miRNAs) are increasingly assessed in biological fluids, for example, in samples obtained by bronchoalveolar lavage (BAL). "Post-collection kinetics" of miRNA expression levels, however, have not been investigated to date. In these experiments, we analyzed the dynamic expression profile of 5 different miRNAs (miR-17, miR-19b, miR ...
Brock Matthias, Rechsteiner Thomas, Kohler Malcolm, Franzen Daniel, Huber Lars C.   +4 more
openaire   +4 more sources

Histoplasma capsulatum Infection in an Allogeneic Hematopoietic Stem Cell Transplant Patient Receiving Voriconazole Prophylaxis [PDF]

, 2020
Histoplasma capsulatum infection is a rare complication in the allogeneic stem cell transplant patients. Minimal guidance exists on how to appropriately manage histoplasmosis in these patients.
Agrawal, Vaibhav, Brinda, Bryan J., Farag, Sherif S.   +2 more
core   +1 more source

Interactions Between Active Matters and Endogenous Fields

Advanced Materials, EarlyView.
This review synthesizes endogenous field information and computational methods in contexts such as cancer, wounds, and biofilms. It organizes NAMs and AAMs by sensing, transmitting, and executing functions, compares their limitations, and from these contrasts proposes design strategies for next‐generation AAMs, offering perspectives to foster ...
Jinwei Lin, Qiaoxin Guan, Jiangqi Feng, Shuqin Chen, Leilei Xu, Jianguo Guan, Samuel Sánchez   +6 more
wiley   +1 more source

Alterations in vasodilator-stimulated phosphoprotein (VASP) phosphorylation: associations with asthmatic phenotype, airway inflammation and β\u3csub\u3e2\u3c/sub\u3e-agonist use [PDF]

, 2006
Background Vasodilator-stimulated phosphoprotein (VASP) mediates focal adhesion, actin filament binding and polymerization in a variety of cells, thereby inhibiting cell movement.
Batra, Vikas, Cirelli, Rosemary, Foster, Gayle C., Hastie, Annette T., Hawkins, Gregory A., Peters, Stephen P., Rybinski, Katherine A., Wu, Min, Zangrilli, James G.   +8 more
core   +1 more source

Intracellular Concentrations of Fosfomycin in Alveolar Macrophages from Weaning Piglets [PDF]

, 2015
At weaning, piglets are more susceptible to infectious diseases, being respiratory syndromes one of the most frequent conditions. Fosfomycin is indicated for the treatment of a variety of porcine bacterial pathogens, with MIC90 ranging between 0.25-0.50 ...
Dieguez, Susana Nelly, Fernández Paggi, María Belén, Martínez, Guadalupe, Pérez, Denisa Soledad, Riccio, Maria Belen, Soraci, Alejandro Luis, Tapia, Maria Ofelia   +6 more
core   +2 more sources