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Novel bronchodilators in asthma
Current Opinion in Pulmonary Medicine, 2010Because of the central role of bronchodilators in the treatment of asthma, in recent years there has been a renewed interest in the field and now once-daily bronchodilators are in development in an attempt to simplify their use.A variety of beta2-agonists with long half-lives, also called ultra long-acting beta2-agonists (ultra-LABAs; indacaterol ...
CAZZOLA M +2 more
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Archives of Internal Medicine, 1979
From the clinician's standpoint, an ideal bronchodilator should have (1) selectivity for bronchial smooth muscle, (2) minimal stimulatory effects on the cardiovascular and central nervous system, (3) prolonged action, (4) rapid onset of action, and (5) oral effectiveness for patient convenience. In addition, bronchodilation should occur in both central
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From the clinician's standpoint, an ideal bronchodilator should have (1) selectivity for bronchial smooth muscle, (2) minimal stimulatory effects on the cardiovascular and central nervous system, (3) prolonged action, (4) rapid onset of action, and (5) oral effectiveness for patient convenience. In addition, bronchodilation should occur in both central
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Bronchodilators for bronchiolitis
1999Bronchiolitis is an acute, highly communicable lower respiratory tract infection. Bronchodilators are commonly used in the management of bronchiolitis in North America, but not in the United Kingdom. The objective of this review was to assess the effects of bronchodilators for bronchiolitis.We searched MEDLINE, EMBASE, Reference Update, reference lists
J D, Kellner +3 more
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Anticholinergic Bronchodilators
1998Publisher Summary Cholinergic bronchomotor activity can be reflexly augmented by a variety of stimuli through the neural pathways. In human airways, the bulk of efferent autonomic nerves are cholinergic. Branches of the vagus nerve travel along the airways and synapse at peribronchial ganglia, from which short postganglionic nerves travel to smooth ...
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Anticholinergic bronchodilators in combination
Expert Opinion on Pharmacotherapy, 2000Chronic obstructive pulmonary disease (COPD), which affects approximately 14 million Americans, is the fourth leading cause of death in the United States and is responsible for an estimated US$6.5 billion in direct and indirect costs per year [1,2]. Its usual course is a slow deterioration of lung function and progressive breathlessness with activities.
Raymond Pineda, Stephen I. Rennard
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Assessing bronchodilator responsiveness
Journal of Allergy and Clinical Immunology, 1977This report concerns the difficulty in distinguishing variation due to drug effects from the spontaneous daily variation in baseline levels of pulmonary function in the evaluation of bronchodilator responsiveness in asthmatic children. Both prospective and retrospective studies were employed to assess the importance of the influence of the baseline ...
Sanford E. Avner +2 more
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A Paradoxical Effect of Bronchodilators
Chest, 1997Lactic acidosis previously has been reported during treatment of asthma with beta-2 agonists. However, this metabolic disturbance never had any clinical consequence. We report a case of a patient with asthma in whom beta-2 agonist administration increased dyspnea by metabolic acidosis due to a sharp increase in lactate levels (hyperlactatemia) and led ...
Bertrand Guidet +4 more
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Beta-Adrenergic Bronchodilators [PDF]
Respiration, 1986 Long-acting beta 2-selective agonists have become a major form of therapy of reversible airway obstruction. Modern agents are effective by all routes of administration and can both eliminate bronchospasm as well as prevent its occurrence. Many drugs such as albuterol, terbutaline and fenoterol have similar pharmacologic profiles, and there is ...
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Combination Bronchodilator Therapy
Drugs, 1982Bronchodilators may be classified into 3 groups: anticholinergics, beta-adrenoceptor agonists and methylxanthines. These drugs act through related biochemical pathways and there are theoretical reasons for expecting beneficial additive or synergistic interactions between them.
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