Results 101 to 110 of about 20,435 (278)

Current and potential improvements in the treatment of asthma from increased understanding of airway pathophysiology

Allergology International, 2002
The mainstay of chronic asthma management consists of using pharmacological agents that induce bronchodilatation, such as short-acting β-adrenergic receptor agonists (bronchodilators or relievers), and that control the chronic inflammatory process, such ...
Kian Fan Chung
doaj   +1 more source

Efficacy of tiotropium-olodaterol fixed-dose combination in COPD [PDF]

, 2016
Tiotropium-olodaterol, formulated in the Respimat soft-mist inhaler, is an inhaled fixed-dose combination (FDC) of a long-acting muscarinic antagonist (LAMA) and a long-acting beta(2)-agonist (LABA), commercialized under the name of Spiolto or Stiolto ...
Brusselle, Guy, Derom, Eric, Joos, Guy
core   +1 more source

G Protein‐Coupled Receptor Signaling: Implications and Therapeutic Development Advances in Cancers

MedComm, Volume 6, Issue 10, October 2025.
G protein‐coupled receptors (GPCRs) are the dynamic protein family in the human genome. GPCR dysregulation aids in the advancement of cancer through increased migration, survival, and proliferation. Novel treatments that target GPCR signaling include orthosteric ligands, biased receptor mutants, PROTACs, and antibody–drug conjugates.
Inamu Rashid Khan, Sana Khurshid, Saud Almawash, Rakesh Kumar, Ammira S. Al‐Shabeeb Akil, Ajaz A. Bhat, Muzafar A. Macha   +6 more
wiley   +1 more source

Are there specific clinical characteristics associated with physician’s treatment choices in COPD?

Respiratory Research, 2019
Background The number of pharmacological agents and guidelines available for COPD has increased markedly but guidelines remain poorly followed. Understanding underlying clinical reasoning is challenging and could be informed by clinical characteristics ...
Nicolas Roche, Anestis Antoniadis, David Hess, Pei Zhi Li, Eric Kelkel, Sylvie Leroy, Christophe Pison, Pierre-Régis Burgel, Bernard Aguilaniu, COLIBRI COPD Research Group   +9 more
doaj   +1 more source

Risk factors for COPD exacerbations in inhaled medication users: the COPDGene study biannual longitudinal follow-up prospective cohort. [PDF]

, 2016
BackgroundDespite inhaled medications that decrease exacerbation risk, some COPD patients experience frequent exacerbations. We determined prospective risk factors for exacerbations among subjects in the COPDGene Study taking inhaled medications ...
,, Bowler, Russell P, Busch, Robert, Dransfield, Mark T, Han, MeiLan K, Hersh, Craig P, Regan, Elizabeth A, van Beek, Edwin, Wells, J Michael   +8 more
core   +4 more sources

Study Design and Rationale for The Breathe Easier With Tadalafil Therapy for Exercise‐Related Dyspnea in COPD‐PH (BETTER COPD‐PH)

Pulmonary Circulation, Volume 15, Issue 4, October 2025.
ABSTRACT Dyspnea, a debilitating symptom of COPD, worsens health‐related quality of life (HRQL), reduces daily physical activity, increases health care utilization, and is more closely associated with survival than airflow limitation. Thus, having treatments that reduce dyspnea in COPD is important.
Elena DeSanti, Matthew Jankowich, Gaurav Choudhary, Alan Morrison, Zachary K. Stanley, Eric Garshick, Marilyn L. Moy, Mohleen Kang, Cherry Wongtrakool, Ruxana T. Sadikot, Edward C. Dempsey, Matthew Griffith, Duc M. Ha, Christopher H. Schmid, Ronald H. Goldstein, Sharon Rounds, the BETTER COPD‐PH Study Group, Jayashri Aragam, Brack Hattler, Tim Lahm, Kristin L. Bailey, Debra Romberger, Gautam Kumar, Joshua Detelich, Jussi Saukkonen, Emily Wan, Shelsey Johnson, Malisa Barber, Christopher Halladay, Kathleen LaCerda, Renee LeClaire, Alexis Thavenet, Makkawi Makkawi, Mehret Tekle, Susan Burbach, Jenna Eggert, Julia Gillotti, Sridhar Tanukonda, Tiffany Elliott, Radhika Mungara, Matthew Lejy   +40 more
wiley   +1 more source

Evaluating bronchodilator response in pediatric patients with post-infectious bronchiolitis obliterans: use of different criteria for identifying airway reversibility

Jornal Brasileiro de Pneumologia
Objective: Post-infectious bronchiolitis obliterans (PIBO) is a clinical entity that has been classified as constrictive, fixed obstruction of the lumen by fibrotic tissue.
Rita Mattiello, Paula Cristina Vidal, Edgar Enrique Sarria, Paulo Márcio Pitrez, Renato Tetelbom Stein, Helena Teresinha Mocelin, Gilberto Bueno Fischer, Marcus Herbert Jones, Leonardo Araújo Pinto   +8 more
doaj   +1 more source

Equivalência farmacêutica da formulação combinada de budesonida e formoterol em cápsula única com dispositivo inalador de pó Pharmaceutical equivalence of the combination formulation of budesonide and formoterol in a single capsule with a dry powder inhaler

Jornal Brasileiro de Pneumologia, 2012
OBJETIVO: Avaliar a equivalência farmacêutica da formulação teste (associação fixa de budesonida e fumarato de formoterol em cápsula única dispensada com o dispositivo Aerocaps®) em relação a uma formulação referência (budesonida e fumarato de formoterol
Marina Andrade-Lima, Luiz Fernando Ferreira Pereira, Ana Luisa Godoy Fernandes   +2 more
doaj   +1 more source

Combination inhaled steroid and long-acting beta-agonist in addition to tiotropium versus tiotropium or combination alone for chronic obstructive pulmonary disease (Review) [PDF]

, 2011
Background The long-acting bronchodilator tiotropium and single inhaler combination therapy of inhaled corticosteroids and long-acting beta(2)-agonists are both commonly used for maintenance treatment of chronic obstructive pulmonary disease.
Appleton, Barr, Beeh, Effing, Fang, Lacasse, Nannini, Nannini, Nannini, Welsh, Yang   +10 more
core   +1 more source

Indacaterol/glycopyrronium versus salmeterol/fluticasone in Asian patients with COPD at a high risk of exacerbations: results from the FLAME study

International Journal of COPD, 2017
Jadwiga A Wedzicha,1 Nanshan Zhong,2 Masakazu Ichinose,3 Michael Humphries,4 Robert Fogel,5 Chau Thach,5 Francesco Patalano,6 Donald Banerji5 1National Heart and Lung Institute, Imperial College London, London, UK; 2State Key Laboratory of Respiratory ...
Wedzicha JA, Zhong N, Ichinose M, Humphries M, Fogel R, Thach C, Patalano F, Banerji D   +7 more
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