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Degradation of Bronchodilator Agents in Oxymix System

Journal of Pharmaceutical Sciences, 1973
Abstract: Known amounts of isoproterenol, phenylephrine, and epinephrine were added to the aqueous oxymix system and thereby exposed to potential redox destruction. Thirty minutes later, recoveries of isoproterenol and phenylephrine were 89-100% and 89-108%, respectively, while the recovery of epinephrine was 53-79%.
G H, Kronberg, B H, Takman
exaly   +3 more sources

In vitro studies on the relative potency of bronchodilator agents

Lung, 1985
This study describes a rapid in vitro assay for the order of potency of bronchodilator drugs using specific binding of (−)-[3H] dihydroalprenolol ([3H]DHA) to rat lung membranes. Under linear conditions with respect to tissue, specific binding of [3H]DHA showed saturability, rapid kinetics of association and dissociation of radioligand, and ...
J H, Fleisher, J L, Pinnas
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New isoquinolines as potential bronchodilator agents

Tetrahedron, 1973
Abstract The syntheses of 5-hydroxy-6-hydroxymethyl, 6-hydroxy-7-hydroxymethyl and 7-hydroxy-6-hydroxymethyl-1-(3,4,5-trimethoxybenzyl)-1,2,3,4-tetrahydroisoquinolines ( 1d ), ( 1b ) and ( 1c ) respectively, are described.
S.F. Dyke, A.W.C. White, D. Hartley
openaire   +1 more source

[Measurement of the effect of a bronchodilator agent].

Schweizerische Rundschau fur Medizin Praxis = Revue suisse de medecine Praxis, 1990
Response in a bronchodilator must be expressed by the combining the largest amplitude of response with the highest reproducibility. The forced expiratory volume in the first second (FEV1) meets these conditions and thus represents the best test. The bronchodilator response is commonly expressed in percent of the initial FEV1.
openaire   +1 more source

[Inhaled bronchodilators and mucolytic agents in cystic fibrosis].

Archives de pediatrie : organe officiel de la Societe francaise de pediatrie, 2004
Poor clearance of airway secretions contributes to the pulmonary disease in cystic fibrosis (CF). Bronchodilator therapy might benefit in CF, but the efficacy is controversial. Effects of mucolytic agents have not been demonstrated conclusively. Only, efficacy of recombinant human deoxyribonuclease (rhDNase) is established with a rapid onset of benefit.
P, Le Roux, B, Le Luyer
openaire   +1 more source

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