Results 71 to 80 of about 1,562,206 (187)

Effects of indacaterol versus tiotropium on exercise tolerance in patients with moderate COPD: a pilot randomized crossover study

Jornal Brasileiro de Pneumologia
Objective: To compare a once-daily long-acting β2 agonist (indacaterol 150 µg) with a once-daily long-acting anticholinergic (tiotropium 5 µg) in terms of their effects on exercise endurance (limit of tolerance, Tlim) in patients with moderate COPD ...
Danilo Cortozi Berton, Álvaro Huber dos Santos, Ivo Bohn Jr., Rodrigo Quevedo de Lima, Vanderléia Breda, Paulo José Zimermann Teixeira   +5 more
doaj   +1 more source

Glycyrrhizic Acid Relieves Fatigue Induced by Acute and Chronic Exercise in Mice via Inhibition of the NF‐κB/NLRP3 Signaling Pathway

Brain and Behavior, Volume 16, Issue 10, October 2026.
Molecular mechanism diagram of Gly‐A in the treatment of acute and chronic exercise‐fatigue. ABSTRACT Background Glycyrrhizic acid (Gly‐A) exhibits anti‐inflammatory and antioxidant effects in various central nervous system disorders. Acute fatigue and chronic fatigue (CF) are associated with serious physical and psychological effects.
Xin‐ying Cai, Wen‐jun Li, Cai‐xia Chen, Lu Peng, Li‐chao Yang, Xiao‐ning Lin, Hong‐tao Liu, Jian‐bo Jia, Yan‐chao Jiao, Ying Li   +9 more
wiley   +1 more source

Multisystem Complications in Non‐Transfusion‐Dependent β‐Thalassemia Intermedia: A Case Highlighting the Need for Early Intervention

Clinical Case Reports, Volume 14, Issue 10, October 2026.
ABSTRACT This case highlights that severe complications of non‐transfusion‐dependent β‐thalassemia may be preventable with appropriate monitoring and timely intervention; however, once established, multisystem complications can be challenging to treat.
Oldooz Aloosh, Seyedeh Esmat Hosseini, Mohammad Karimi   +2 more
wiley   +1 more source

Determinants of invasive ventilation in infants with acute bronchiolitis: an observational study of pre-hospital and in-hospital treatments [PDF]

Einstein (São Paulo)
Objective: To analyze the factors associated with invasive ventilation in infants admitted to the hospital with acute bronchiolitis and identify the treatments administered before and during hospitalization.
Carlos Henrique Araújo Carvalho, Cristina Ortiz Sobrinho Valete, Carolina Perez Montenegro, Esther Angelica Luiz Ferreira   +3 more
doaj   +1 more source

Is It Safe to Reduce Inhaled Corticosteroid Dose in Severe Asthma Patients Receiving Biologic Therapy?

Clinical and Translational Allergy, Volume 16, Issue 10, October 2026.
ABSTRACT Background Biologic therapies can control severe asthma and may modify its natural history beyond symptom control. However, step‐down is not standardized, and its safety has not been clearly established. Methods This single‐center retrospective cohort study reviewed adults with severe asthma on biologics (January 2019–May 2024).
Nagihan Orhan Özer, Betül Özdel Öztürk, Begüm Görgülü Akın, Ceren Kaplankıran, Şadan Soyyiğit   +4 more
wiley   +1 more source

Bronchodilator responsiveness and reported respiratory symptoms in an adult population. [PDF]

, 2013
The relationship between patient-reported symptoms and objective measures of lung function is poorly understood.To determine the association between responsiveness to bronchodilator and respiratory symptoms in random population samples.4669 people aged ...
A. Sonia Buist (390258), Robert Cowie, Kenneth R. Chapman (390254), Shawn Aaron (390256), CanCOLD Collaborative Research Group, Don D. Sin (116489), Wan C Tan, Kenneth R Chapman, Denis E. O’Donnell (390259), Robert Cowie (390255), Paul Hernandez (390253), Darcy D Marciniuk, Francois Maltais, A Sonia Buist, J Mark FitzGerald, Darcy D. Marciniuk (390257), Jean Bourbeau, Jean Bourbeau (390252), Francois Maltais (2342827), Paul Hernandez, Denis E O'Donnell, Shawn Aaron, J. Mark FitzGerald (115951), Don D Sin, Wan C. Tan (390251), Hernandez Paul, FitzGerald J. Mark, Maltais Francois, Aaron Shawn, Bourbeau Jean, Chapman Kenneth R., Tan Wan C., Cowie Robert, Buist A. Sonia, O’Donnell Denis E., Sin Don D., Marciniuk Darcy D.   +36 more
core   +1 more source

Change in inhaled corticosteroid treatment and COPD exacerbations: an analysis of real-world data from the KOLD/KOCOSS cohorts

Respiratory Research, 2019
Background This cohort study of patients with chronic obstructive pulmonary disease (COPD) was performed to evaluate the status of inhaled corticosteroid (ICS) prescriptions following the 2017 revision of the Global Initiative for Chronic Obstructive ...
Se Hee Lee, Ji-Hyun Lee, Ho Il Yoon, Hye Yun Park, Tae-Hyung Kim, Kwang Ha Yoo, Yeon-Mok Oh, Ki Suk Jung, Sang-Do Lee, Sei Won Lee   +9 more
doaj   +1 more source

Curcumin Improves Silica Induced Lung Fibrosis by Targeting TLR4‐NLRP3 Inflammasome and TGF‐β Inhibition in Mice Model

Journal of Biochemical and Molecular Toxicology, Volume 40, Issue 10, October 2026.
ABSTRACT Silicosis, a progressive occupational lung disease, caused by inhalation of crystalline silica particles, leads to chronic inflammation and pulmonary fibrosis. Increasing evidence suggests that activation of the TLR4/NF‐κB signaling pathway and NLRP3 inflammasome plays a crucial role in silica‐induced lung injury.
Sneha Kumari, Payal Singh, D. Dash, Rashmi Singh   +3 more
wiley   +1 more source

Structure and functional impact of seed region variant in MIR-499 gene family in bronchial asthma

Respiratory Research, 2017
Background Small non-coding RNAs (microRNAs) have been evolved to master numerous cellular processes. Genetic variants within microRNA seed region might influence microRNA biogenesis and function.
Eman A. Toraih, Mohammad H. Hussein, Essam Al Ageeli, Eman Riad, Nouran B. AbdAllah, Ghada M. Helal, Manal S. Fawzy   +6 more
doaj   +1 more source

The Clinical Characteristic and Prognostic Value of Frailty in Elderly COPD Patients

Journal of Cachexia, Sarcopenia and Muscle, Volume 17, Issue 5, October 2026.
ABSTRACT Background and Objective Frailty, as one of the extrapulmonary comorbidities of chronic obstructive pulmonary disease (COPD), is highly prevalent in COPD patients. The primary objective of this research was to assess how frailty influences subsequent exacerbation and augments the predictive capacity of dyspnoea or the exacerbation history ...
Tao Li, Ping Zhang, Qing Song, Cong Liu, Ling Lin, Yuqin Zeng, Ping Chen   +6 more
wiley   +1 more source