Results 11 to 20 of about 430 (107)
Geophysical Monograph Series, Page 263-304., 2021 Exploring the links between Large Igneous Provinces and dramatic environmental impact
An emerging consensus suggests that Large Igneous Provinces (LIPs) and Silicic LIPs (SLIPs) are a significant driver of dramatic global environmental and biological changes, including mass extinctions.
Jessica H. Whiteside +3 more
wiley +1 more source
Cancer‐Associated BCL‐2 Mutants Reveal Mechanisms Towards Venetoclax Resistance
Advanced Science, EarlyView.Venetoclax (VEN) resistance in chronic lymphocytic leukemia arises from diverse BCL2 mutations. We map mechanisms contributing to VEN resistance across common BCL‐2 variants. G101V and D103Y reduce drug binding and increase sequestration of pro‐apoptotic proteins. V156D blocks VEN allosterically.
Jonas Aufdermauer +9 more
wiley +1 more source
Advanced Science, EarlyView.This study shows that a PARP inhibitor combined with anlotinib, administered as bridging therapy, preconditions the tumor microenvironment to enhance the infiltration and antitumor activity of subsequently infused CAR‐T cells across preclinical ovarian cancer models, supporting bridging therapy as a promising strategy to address limited CAR‐T cell ...
Huayi Li +20 more
wiley +1 more source
‘I was treated as a deficit’: Immigrant teachers' career progression in Australia
British Educational Research Journal, EarlyView.Abstract Immigrant teachers have long been recruited through skilled and employer‐sponsored migration schemes to address teacher shortages in Australia, yet their career trajectories remain constrained by systemic inequities that limit their integration and professional development opportunities.
Ching Ting Tany Kwee +2 more
wiley +1 more source
Classroom boundaries and teacher agency: Challenges of implementing Ireland's new primary curriculum
The Curriculum Journal, EarlyView.Abstract This article reports on a doctoral study examining teacher agency in one Irish primary school at a timely moment ahead of the implementation of the new Primary Curriculum Framework in September 2025. The framework embeds teacher agency as a central professional principle, yet findings from this study reveal a more cautious and bounded reality.
Máiréad Nally +2 more
wiley +1 more source
Geological Journal, EarlyView.This study reports the exceptional preservation of the Eocene freshwater bivalve Batissa sitakaraensis from Hokkaido, Japan. Multimodal analyses reveal that both the aragonitic shell mineralogy and the delicate organic periostracum retain their original structural and chemical characteristics after millions of years.
Taro Yoshimura +4 more
wiley +1 more source
Oikos, EarlyView.Understanding the scales and mechanisms by which species composition interacts with ecosystem functions is critical for forecasting the effects of environmental perturbations on ecosystem services. However, the linkages between what regulates the ecosystem functions of dispersal‐capable networks of communities (metacommunities) and what regulates a ...
Thomas P. Shannon, Evelyn E. Gaiser
wiley +1 more source
Influence of heme and pH on the oligomeric states of Brucella melitensis bacterioferritin
Acta Crystallographica Section D, EarlyView.The oligomerization of B. melitensis bacterioferritin (BmBfr) was studied using X‐ray crystallography, size‐exclusion chromatography and thermal shift analysis. These techniques allowed the characterization of both apo and holo BmBfr, highlighting the impact of heme and pH on the oligomerization mechanism.Bacterioferritin from Brucella melitensis ...
Tanguy Scaillet +2 more
wiley +1 more source
The British Journal of Sociology, EarlyView.ABSTRACT Tracing the early adoption of computer gang databases by the Los Angeles County Sheriff's Department and the Los Angeles Police Department in the 1980s to the deployment of computationally‐assisted surveillance during the Vietnam War, this paper uses a genealogical approach to compare surveillance technologies developed across the arc of ...
Christina Hughes
wiley +1 more source
Does Inequality Blur Class Lines? Meritocratic Attitudes in Comparative Perspective
The British Journal of Sociology, EarlyView.ABSTRACT Scholars of inequality generally find that lower‐class individuals are more skeptical of meritocratic narratives that link economic success to individual work effort. However, past research has yielded inconclusive findings about how economic inequality affects meritocratic attitudes across different class groups.
Roshan K. Pandian, Ronald Kwon
wiley +1 more source