Results 301 to 310 of about 1,154,949 (367)

Tks4‐Targeted Gene Therapy Inhibited White Adipocyte Hypertrophy in Mice

open access: yesThe FASEB Journal, Volume 40, Issue 2, 31 January 2026.
Tks4 knockout or knockdown by AAV mediated shRNA both successfully restricted adipocyte hypertrophy in high fat diet. The reduction of TAG was validated by biochemistry and lipidomics analyses. This study suggested a potential of Tks4 targeted therapy in obesity intervention. ABSTRACT Obesity is one of the most prevalent public health issues worldwide,
Meng Tian   +5 more
wiley   +1 more source

The Histone Demethylase UTX Promotes Brown Adipocyte Thermogenic Program Via Coordinated Regulation of H3K27 Demethylation and Acetylation*

open access: yesJournal of Biological Chemistry, 2015
Lin Zha   +8 more
semanticscholar   +1 more source

Biochemical and Physiological Effects of Galanin in Health and Disease

open access: yesThe FASEB Journal, Volume 40, Issue 2, 31 January 2026.
Galanin is a biologically active neuropeptide hormone that mediates its effects through three galanin receptors. Galanin signaling induces changes in glucose homeostasis amongst others and plays a dynamic role in the physiological health of many organ systems.
Patrick Mireles   +3 more
wiley   +1 more source

TNF/TNFR1 is a Key Regulator of Prolonged Fasting‐Induced Decrease in Adipose Tissue

open access: yesThe FASEB Journal, Volume 40, Issue 1, 15 January 2026.
Fasting triggers an inflammatory response and increases sympathetic tone in white adipose tissue (WAT), promoting fat breakdown and tissue remodeling. Fasting sparks an inflammatory response that underpins the reduction in adipocyte size and WAT remodeling.
Amanda Carla Clemente de Oliveira   +12 more
wiley   +1 more source

A Somatic Mutation in HIF‐2α Affects Glucose and Lipid Metabolism via CD36 and Ceramide

open access: yesThe FASEB Journal, Volume 40, Issue 1, 15 January 2026.
A mutation within the C‐terminal transactivation domain of HIF‐2α enhances Cd36 expression by increased transactivation activity, leading to ceramide accumulation and disruption of glucose and lipid metabolism. Inhibition of ceramide synthesis by myriocin reduces ceramide levels and ameliorates these metabolic disturbances.
Feiqiong Gao   +9 more
wiley   +1 more source

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