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Identification of brown adipocyte progenitors

, 2020
Today’s therapy against obesity uses life style changing and/or medication, but is little promising so far. Therefore it is important to develop new and successful therapeutically strategies against obesity. Nowadays brown adipose tissue gives hope to develop new therapeutically strategies and therapies against obesity because of its energy combusting ...
Verena Rau
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Brown Adipocyte ADRB3 Mediates Cardioprotection via Suppressing Exosomal iNOS

Circulation Research, 2022
Background: The ADRB3 (β3-adrenergic receptors), which is predominantly expressed in brown adipose tissue (BAT), can activate BAT and improve metabolic health.
Jingrong Lin, Li-Li-Qiang Ding, Lian Xu, Jun Huang, Ze-Bei Zhang, Xiao-Hui Chen, Yu-Wen Cheng, C. Ruan, P. Gao   +8 more
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Huang-Qi San ameliorates hyperlipidemia with obesity rats via activating brown adipocytes and converting white adipocytes into brown-like adipocytes

Phytomedicine, 2020
Brown adipose tissue (BAT) activation is a promising therapeutic target to treat hyperlipidemia with obesity. Huang-Qi San (HQS), an traditional Chinese medicine, can ameliorate hyperlipidemia with obesity, but its mechanism of action (MOA) is not understood.To articulate the MOA for HQS with animal models.The main chemical constituents of HQS were ...
Mengjiao Hao, Zhuoji Guan, Ying Gao, Juling Xing, Xinxin Zhou, Chunyi Wang, Jun Xu, Weimin Li   +7 more
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Isolation and Characterization of Human Brown Adipocytes

2022
Brown adipose tissue (BAT) is a thermoregulatory fat with energy-consuming properties. The location and heterogeneity of this tissue makes it complicated to sample before and after interventions in humans, and an in vitro model for mechanistic and molecular studies is therefore of great value.
Scheele, Camilla, Henriksen, Tora Ida, Nielsen, Søren   +2 more
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Succinate Oxidation in Hamster Brown Adipocytes

1978
In a suspension of isolated hamster brown adipocytes succinate can be oxidized at a high rate. This oxidation capacity is found to be mainly extracellular and can be totally blocked by the SH-reagent DTNB. In the intact cell succinate is found to be oxidized very slow probably as a function of a low transport rate over the membrane(s).
B, Pettersson, P, Lundberg, V S, Bernson
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Zinc alpha2 glycoprotein promotes browning in adipocytes

Biochemical and Biophysical Research Communications, 2018
Recent studies have highlighted recruiting and activating brite adipocytes in WAT (so-called "browning") would be an attractive anti-obesity strategy. Zinc alpha2 glycoprotein (ZAG) as an important adipokine, is reported to ameliorate glycolipid metabolism and lose body weight in obese mice. However whether the body reducing effect mediated by browning
Xin-Hua Xiao, Xiao-Yan Qi, Ya-Di Wang, Li Ran, Jing Yang, Huan-Li Zhang, Can-Xin Xu, Ge-Bo Wen, Jiang-Hua Liu   +8 more
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Determinants of brown adipocyte development and thermogenesis

International Journal of Obesity, 2010
The brown adipocyte is a thermogenic cell. Its thermogenic potential is conferred by uncoupling protein-1, which 'uncouples' adenosine triphosphate synthesis from energy substrate oxidation. Brown fat cells in so-called classical brown adipose tissue (BAT) share their origin with myogenic factor-5-expressing myoblasts.
D, Richard, A C, Carpentier, G, Doré, V, Ouellet, F, Picard   +4 more
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Beta-adrenergic stimulation of brown adipocyte proliferation

American Journal of Physiology-Cell Physiology, 1988
The mechanisms of brown adipose tissue (BAT) growth were studied by quantitative photonic radioautography using tritiated thymidine to follow mitotic activity. To identify the nature of the adrenergic pathways mediating brown adipocyte proliferation and differentiation, the effects of cold exposure (4 days at 4 degrees C) on BAT growth were compared ...
A, Géloën, A J, Collet, G, Guay, L J, Bukowiecki   +3 more
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Genetic Studies of Brown Adipocyte Induction

The Journal of Nutrition, 2000
We seek to discover an effective method for utilizing thermogenesis to reduce the caloric load in obese individuals. Experimental evidence indicates that nonshivering thermogenesis is the most effective cellular and biochemical mechanism known for reducing excessive adiposity. In this presentation, we describe our experiments aimed at understanding how
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Cannabidiol promotes browning in 3T3-L1 adipocytes

Molecular and Cellular Biochemistry, 2016
Recruitment of the brown-like phenotype in white adipocytes (browning) and activation of existing brown adipocytes are currently being investigated as a means to combat obesity. Thus, a wide variety of dietary agents that contribute to browning of white adipocytes have been identified.
Hilal Ahmad, Parray, Jong Won, Yun
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