Results 91 to 100 of about 292,612 (343)

Adipose-Derived Stem Cells: Isolation, Characterization, and Differentiation Potential

Cell Transplantation, 2013
In mammals, the two main types of adipose tissues, white and brown adipose tissues, exert different physiological functions. White adipose tissue (WAT) is for storing energy, while brown adipose tissue (BAT) is for energy consumption.
Shyh-Jer Huang, Ru-Huei Fu, Woei-Cherng Shyu, Shih-Ping Liu, Gwo-Ping Jong, Yung-Wei Chiu, Hsiao-Su Wu, Yung-An Tsou, Chao-Wen Cheng, Shinn-Zong Lin M.D., Ph.D.   +9 more
doaj   +1 more source

Adipocyte‐Derived Exosomal miR‐5099 Mitigates M1 Macrophage Polarization and Adipose Inflammation via c‐Met/NF‐κB Axis to Improve Metabolic Health

Advanced Science, EarlyView.
Celastrol upregulates adipocyte‐derived exosomal miR‐5099, suppressing the macrophage c‐Met/NF‐κB axis to mitigate pro‐inflammatory M1 polarization and adipose inflammation. These miR‐5099‐enriched exosomes also act as endocrine signals targeting the liver, muscle, and adipocytes to significantly enhance systemic insulin sensitivity.
Ping Tang, Lixin Tai, Hongxia Xu, Dongliang Zhu, Jiajia Li, Hao Feng, Jinghui Cui, Shuhai Lin, Li‐jun Di, Li Wang   +9 more
wiley   +1 more source

Brown adipose tissue is associated with cardiometabolic health

Nature Medicine, 2021
T. Becher, Srikanth Palanisamy, Daniel J. Kramer, M. Eljalby, S. J. Marx, A. Wibmer, Scott D Butler, Caroline S. Jiang, Roger A. Vaughan, H. Schöder, A. Mark, P. Cohen   +11 more
semanticscholar   +1 more source

Cold-Induced Thermogenesis Depends on ATGL-Mediated Lipolysis in Cardiac Muscle, but Not Brown Adipose Tissue

Cell Metabolism, 2017
Summary Fatty acids (FAs) activate and fuel UCP1-mediated non-shivering thermogenesis (NST) in brown adipose tissue (BAT). Release of FAs from intracellular fat stores by adipose triglyceride lipase (ATGL) is considered a key step in NST.
R. Schreiber, C. Diwoky, Gabriele Schoiswohl, Ursula Feiler, Nuttaporn Wongsiriroj, M. Abdellatif, D. Kolb, J. Hoeks, E. Kershaw, S. Sedej, P. Schrauwen, G. Haemmerle, R. Zechner   +12 more
semanticscholar   +1 more source

Advanced Corneal Hydrogels: From Passive Replacement to Active Regeneration and Intelligent Interaction

Advanced Science, EarlyView.
This review charts the evolution of corneal hydrogels from passive replacements to active and intelligent systems, evaluating natural and synthetic materials while addressing design challenges such as transparency and strength. Advanced applications such as scarless wound healing, three‐dimensional bioprinting, and smart wearables are highlighted to ...
Xinwei Wang, Wen Zhou, Haotian Xue, Wenjun Xue, Guangping Gao, Bing Zhu, Hongyuan Song, Qingqiang Xu, Jing Zhao, Wei Shen   +9 more
wiley   +1 more source

Mfn2 is critical for brown adipose tissue thermogenic function

EMBO Journal, 2017
Mitochondrial fusion and fission events, collectively known as mitochondrial dynamics, act as quality control mechanisms to ensure mitochondrial function and fine‐tune cellular bioenergetics.
Marie Boutant, Sameer S. Kulkarni, Magali Joffraud, Joanna Ratajczak, Miriam Valera-Alberni, R. Combe, A. Zorzano, C. Cantó   +7 more
semanticscholar   +1 more source

Cars2‐Mediated Cysteine Catabolism Drives Brown Fat Development and Thermogenesis Through Persulfidating EBF2

Advanced Science, EarlyView.
We demonstrate that Cars2, a cysteine catabolic enzyme in mouse iBAT, is critical for cold tolerance and brown adipocyte differentiation. Through its CPERS activity, Cars2 produces CysSSH/H2S to induce EBF2 persulfidation, promoting its interaction with PPARγ and BRG1 to enhance thermogenic gene expression.
Xin Peng, Hongyong Song, Yin Long, Kaimin Wu, Yinkun Fu, Wenkai Zhou, Wenyan Li, Zhe Shi, Xu‐Yun Zhao   +8 more
wiley   +1 more source

Brown adipose tissue macrophages control tissue innervation and homeostatic energy expenditure

Nature Immunology, 2017
Tissue macrophages provide immunological defense and contribute to the establishment and maintenance of tissue homeostasis. Here we used constitutive and inducible mutagenesis to delete the nuclear transcription regulator Mecp2 in macrophages.
Yochai Wolf, S. Boura-Halfon, N. Cortese, Zhana Haimon, Hadas Sar Shalom, Y. Kuperman, V. Kalchenko, A. Brandis, Eyal David, Yifat Segal-Hayoun, Louise Chappell-Maor, A. Yaron, Steffen Jung   +12 more
semanticscholar   +1 more source

Erasable FAP Targeted Spray‐On Probe for Fluorescence‐Guided Surgery

Advanced Science, EarlyView.
We present the first erasable spray‐on probe for fluorescence‐guided surgery. Following topical delivery, FAP‐FLASH550 targets fibroblast activation protein–expressing stromal cells, delineating tumor margins with high tumor‐to‐background ratios. A 365 nm UV light pulse rapidly erases fluorescent signals through triazene photodegradation and subsequent
Zachary Rabinowitz, Riley J. Deutsch‐Williams, Ralph Weissleder   +2 more
wiley   +1 more source

[18F]F-AraG imaging reveals association between neuroinflammation and brown- and bone marrow adipose tissue

Communications Biology
Brown and brown-like adipose tissues have attracted significant attention for their role in metabolism and therapeutic potential in diabetes and obesity.
Jelena Levi, Caroline Guglielmetti, Timothy J. Henrich, John C. Yoon, Prafulla C. Gokhale, David A. Reardon, Juliet Packiasamy, Lyna Huynh, Hilda Cabrera, Marisa Ruzevich, Joseph Blecha, Michael J. Peluso, Tony L. Huynh, Sung-Min An, Mark Dornan, Anthony P. Belanger, Quang-Dé Nguyen, Youngho Seo, Hong Song, Myriam M. Chaumeil, Henry F. VanBrocklin, Hee-Don Chae   +21 more
doaj   +1 more source