Results 101 to 110 of about 180,287 (345)

Brown Adipose Tissue: Activation and Metabolism in Humans [PDF]

, 2023
Imane Hachemi, Mueez U-Din
openalex   +1 more source

A Natural Sweetener‐inducible Genetic Switch Controls Therapeutic Protein Expression in Mammals

Advanced Science, EarlyView.
This study develops a natural sweetener, the psicose‐inducible transgene expression (PURE) system based on an Agrobacterium tumefaciens–derived transcriptional repressor PsiR. The PURE system is highly specific to psicose, being insensitive to other sugars and structurally similar molecules.
Longliang Qiao, Zhihao Wang, Shasha Tang, Yuan Fang, Guiling Yu, Xiaoting Qiu, Lingxue Niu, Tao Yan, Xingwan Liu, Xiaoding Ma, Deqiang Kong, Yang Zhou, Ningzi Guan, Jinzhong Tian, Meiyan Wang, Haifeng Ye, Fengfeng Cai   +16 more
wiley   +1 more source

Quantitative evaluation of gap junctions during development of the brown adipose tissue.

Journal of Lipid Research, 1980
Gap junctions of rat brown adipose tissue (BAT) were studied with the freeze-fracture technique during development. The frequency and the mean area of gap junctions increased after birth, reached a maximal development during the functional phase of the ...
G Schneider-Picard, J L Carpentier, L Orci   +2 more
doaj   +1 more source

Effect of Acute Cold Exposure on Energy Metabolism and Activity of Brown Adipose Tissue in Humans: A Systematic Review and Meta-Analysis [PDF]

, 2022
Chuanyi Huo, Zikai Song, Jianli Yin, Ying Zhu, Xiaohan Miao, Honghao Qian, Jia Wang, Lin Ye, Liting Zhou   +8 more
openalex   +1 more source

Targeting the CMKLR1‐Mediated Signaling Rebalances Immunometabolism State in Middle‐Age Testicular Macrophages

Advanced Science, EarlyView.
In middle age, testicular CMKLR1⁺ macrophages exhibited a pro‐inflammatory immunometabolic profile, mediated by adipose signals associated with high BMI. However, inhibition of CMKLR1 signaling, either through Cmklr1 genetic ablation or treatment with a CMKLR1 antagonist peptide, can reverse this phenotype.
Zhendong Zhu, Feifei Du, Yang Liu, Jinchunzi Yang, Lei Ge, Tianxia Xiao, Mengxia Li, Jie Chen, Jia Tang, Yali Yang, Jian V. Zhang   +10 more
wiley   +1 more source

Brown Fat Paucity Due to Impaired BMP Signaling Induces Compensatory Browning of White Fat [PDF]

, 2014
Summary Maintenance of body temperature is essential for survival of homeotherms. Brown adipose tissue (BAT) is a specialized fat tissue that is dedicated to thermoregulation1.
Cypess, Aaron M., Gussoni, Emanuela, Huang, Ping, Huang, Tian Lian, McDougall, Lindsay E., Mishina, Yuji, Schulz, Tim J., Townsend, Kristy L., Tseng, Yu-Hua, Xue, Ruidan   +9 more
core   +1 more source

A Novel CYP2E1 Inhibitor, 4‐Methyl‐5‐Acetylthiazole (Q11), Alleviates Obesity Via Modulating Adipose Inflammation and Mitochondrial Dysfunction

Advanced Science, EarlyView.
Obesity involves chronic inflammation and mitochondrial dysfunction. This study identifies cytochrome P450 2E1 (CYP2E1) as a novel inflammatory target in adipose tissue. Its activity increases in obese mice and correlates with inflammation and mitochondrial impairment.
Jinhuan Qiu, Liyuan Gao, Liyang Wang, Xueke Wang, Lin Jia, Mengyan Deng, Liming Tang, Qiang Wen, Na Gao, Haiwei Xu, Hailing Qiao   +10 more
wiley   +1 more source

[18F]F-AraG imaging reveals association between neuroinflammation and brown- and bone marrow adipose tissue

Communications Biology
Brown and brown-like adipose tissues have attracted significant attention for their role in metabolism and therapeutic potential in diabetes and obesity.
Jelena Levi, Caroline Guglielmetti, Timothy J. Henrich, John C. Yoon, Prafulla C. Gokhale, David A. Reardon, Juliet Packiasamy, Lyna Huynh, Hilda Cabrera, Marisa Ruzevich, Joseph Blecha, Michael J. Peluso, Tony L. Huynh, Sung-Min An, Mark Dornan, Anthony P. Belanger, Quang-Dé Nguyen, Youngho Seo, Hong Song, Myriam M. Chaumeil, Henry F. VanBrocklin, Hee-Don Chae   +21 more
doaj   +1 more source

Shc depletion stimulates brown fat activity in vivo and in vitro. [PDF]

, 2014
Adipose tissue is an important metabolic organ that integrates a wide array of homeostatic processes and is crucial for whole-body insulin sensitivity and energy metabolism.
Bettaieb, Ahmed, Connell, Michelle, Cortopassi, Gino, Fong, Jennifer, Griffey, Stephen, Hagopian, Kevork, Haj, Fawaz, Kim, Kyoungmi, Lam, Adam, Ramsey, Jon, Rowland, Douglas, Sahdeo, Sunil, Tomilov, Alexey, Tomilova, Natalia   +13 more
core   +1 more source

Cidea Targeting Protects Cochlear Hair Cells and Hearing Function From Drug‐ and Noise‐Induced Damage

Advanced Science, EarlyView.
Acquired sensorineural hearing loss is primarily caused by the damage or loss of cochlear hair cells, induced by factors such as noise exposure and ototoxic drugs. The deficiency of apoptosis‐inducing gene Cidea in Cidea KO mice or by delivering CRISPR/SlugCas9‐HF via AAV to edit Cidea effectively alleviated hair cell damage and hearing loss caused by ...
Shasha Zhang, Ruiying Qiang, Yuan Zhang, Jinxian Wan, Chen Tao, Ying Dong, Xujun Tang, Li Xu, Hairong Xiao, Yanqin Lin, Wei Tong, Ying Ma, Yongming Wang, Peng Li, Renjie Chai   +14 more
wiley   +1 more source