Results 251 to 260 of about 175,591 (354)

Vascular Endothelial NAMPT‐Mediated NAD+ Biosynthesis Regulates Angiogenesis and Cardiometabolic Functions in Male Mice

Aging Cell, EarlyView.
Using male vascular endothelial cell–specific Nampt knockout and naturally aged mice, we identified endothelial NAD+ deficiency as a central driver of age‐related angiogenic failure, impaired subcutaneous adipogenesis, and cardiometabolic dysfunction.
Shotaro Kosugi, Shintaro Yamaguchi, Ken Nishioka, Taichi Nagahisa, Yasuhiro Watanabe, Daiki Kojima, Kenji Kaneko, Ryunosuke Mitsuno, Ran Nakamichi, Yoshinaga Kawano, Kenichiro Kinouchi, Koichiro Homma, Takeshi Kanda, Junichiro Irie, Kazutoshi Miyashita, Toshiaki Monkawa, Jun Yoshino, Hiroshi Itoh, Kaori Hayashi   +18 more
wiley   +1 more source

YTHDC1 promotes postnatal brown adipose tissue development and thermogenesis by stabilizing PPARγ. [PDF]

EMBO J
Wang L, Wang Y, Ding K, Li Z, Zhang Z, Li X, Song Y, Xie L, Chen Z.   +8 more
europepmc   +1 more source

TRPM7 Deficiency Accelerates Vascular Senescence by Inhibiting H3K18 Lactylation

Aging Cell, EarlyView.
TRPM7 deficiency reduces lactate production in endothelial cells and downregulates both p300 expression and nuclear translocation. These changes collectively lead to decreased H3K18 lactylation levels. Consequently, this downregulates genes vital for vascular homeostasis while upregulating genes associated with aging and vascular remodeling (including ...
Yue Wang, Jing Chen, Xuan Wang, Jin Li, Shujun Yang, Lingping Zhu, Zhenyu Li, Chuanchang Li, Wanzhou Wu, Yongping Bai   +9 more
wiley   +1 more source

Thermoneutral housing worsens MASLD and reveals defective brown adipose tissue response to β3-adrenergic stimulation. [PDF]

iScience
Martin CMP, Polizzi A, Alquier-Bacquié V, Huillet M, Rives C, Dauriat CJG, Bruse J, Melin V, Naylies C, Lippi Y, Lasserre F, Wan J, Flores-Flores R, Bertrand-Michel J, Blas-Y-Estrada F, Rousseau-Bacquié E, Levade T, Rémignon H, Langin D, Mouisel E, Lotersztajn S, Chassaing B, Gamet-Payrastre L, Guillou H, Ellero-Simatos S, Fougerat A, Loiseau N.   +26 more
europepmc   +1 more source

Caloric Restriction Reprograms Adipose Tissues in Rhesus Monkeys

Aging Cell, EarlyView.
Here we show shared and depot‐specific adaptations to life‐long CR in subcutaneous and visceral adipose depots from advanced‐age male rhesus monkeys. Transcriptomics reveal differences between the depots, as well as shared and distinct CR‐responsive pathways.
Josef P. Clark, Timothy W. Rhoads, Sean J. McIlwain, Michael A. Polewski, Derek M. Pavelec, Ricki J. Colman, Rozalyn M. Anderson   +6 more
wiley   +1 more source

Brown adipose tissue and diet-induced thermogenesis

, 1981
G. R. Hervey, G. Tobin
openalex   +1 more source

Single‐Cell RNA Sequencing Identifies Accumulation of Fcgr2b + Virtual Memory‐Like CD8 T Cells With Cytotoxic and Inflammatory Potential in Aged Mouse White Adipose Tissue

Aging Cell, EarlyView.
Age‐associated accumulation of Fcgr2b + VM‐like CD8 T cells within visceral adipose tissue contributes to inflammation. ABSTRACT Aging and obesity are associated with pro‐inflammatory changes in adipose tissue. Overlapping mechanisms, such as the infiltration of inflammatory macrophages and T cells into visceral adipose tissue, have been implicated in ...
Archit Kumar, Martin O'Brien, Vincent B. Young, Raymond Yung   +3 more
wiley   +1 more source

Understanding the Variability of Peanut‐Oral Immunotherapy Responses by Multi‐Omics Profiling of Immune Cells

Allergy, EarlyView.
This study analyzes molecular drivers of OIT responsiveness. Multi‐omics profiling of peanut‐stimulated PBMCs in a controlled peanut‐OIT trial identifies immune, transcriptomic, and epigenetic changes distinguishing complete responders from incomplete responders. Key findings highlight gastrointestinal immune mechanisms, including extracellular exosome
Aleix Arnau‐Soler, Sarah E. Ashley, Ahla Ghauri, Alexander C. S. N. Jeanrenaud, Ingo Marenholz, Katharina Blumchen, Penelope Cibin, Alisa Iakupova, Norbert Hubner, Kirsten Beyer, Young‐Ae Lee   +10 more
wiley   +1 more source

Endothelial SIRT3 deficiency predisposes brown adipose tissue to whitening in diet-induced obesity. [PDF]

Int J Biol Sci
Zhou Q, Lu Z, Wang B, Wang Y, Li L, You M, Wang L, Cao T, Tong D, Xiang J, Zhao Y, Li Q, Mou A, Shu W, He H, Zhao Z, Liu D, Zhu Z, Gao P, Yan Z.   +19 more
europepmc   +1 more source

The sensory penis: A comprehensive immunohistological and ontogenetic exploration of human penile innervation

Andrology, EarlyView.
Abstract Background Penile sexual sensation relies on intricate neural structures that remain incompletely characterized. Immunohistological insights into their development and organization can enhance understanding of penile neuroanatomy and function, while optimizing surgical outcomes.
Alfonso Cepeda‐Emiliani, María Otero‐Alén, Juan Suárez‐Quintanilla, Marina Gándara‐Cortés, Tomás García‐Caballero, Rosalía Gallego, Lucía García‐Caballero   +6 more
wiley   +1 more source