Results 101 to 110 of about 147,735 (295)
Biology of Sex Differences, 2019 Background The obesity-related risk of developing metabolic syndrome is higher in males than in females of reproductive age, likely due to estrogen-mediated reduced adipose tissue inflammation and fibrosis with hypertrophied adipocytes.
Sujoy Ghosh +7 more
doaj +1 more source
Science-Business eXchange, 2010 German researchers have identified a COX-2–mediated pathway in mice that could trigger weight loss. To use this to treat obesity, the challenge would be to develop compounds that boost activity of the pathway in adipose tissue without increasing COX-2–related inflammation.
openaire +1 more source
Cut the fat: 1% or less campaign [PDF]
, 2001 Plan BIntroduction. Obesity is the leading contributor to the progression of chronic disease and cardiovascular disease is the number one killer of American men and women. Objective.
Schmidt, Amanda E.
core +1 more source
Advanced Science, EarlyView.Light wavelength encodes distinct macrophage fates through mitochondrial and metabolic remodeling. Red 625 nm irradiation induces glycolysis, mitochondrial fission, and M1 polarization, whereas near‐infrared 850 nm irradiation promotes fatty acid oxidation, mitochondrial fusion, and M2 polarization.
Qiusheng Shi +12 more
wiley +1 more source
Brown and Beige Fat: Therapeutic Potential in Obesity
Indonesian Biomedical Journal, 2014 BACKGROUND: The epidemic of obesity and type 2 diabetes presents a serious challenge to scientific and biomedical communities worldwide. There has been an upsurge of interest in the adipocyte coincident with the onset of the obesity epidemic and the ...
Anna Meiliana, Andi Wijaya
doaj +1 more source
Transcriptional fingerprinting of "browning" white fat identifies NRG4 as a novel adipokine [PDF]
, 2014 Brown adipocytes help to maintain body temperature by the expression of a unique set of genes that facilitate cellular metabolic events including uncoupling protein 1-dependent thermogenesis.
Christian, Mark, Christian, M
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NMI Regulates Adipose Adaptive Thermogenesis Through TLR4/IRF3 Signaling to Promote Obesity
Advanced Science, EarlyView.Adipose tissue‐derived NMI is secreted under metabolic stress and suppresses adaptive thermogenesis through TLR4/IRF3 signaling, repressing the PPARα/PGC‐1α/UCP1 thermogenic transcriptional program. Genetic ablation or anti ‐ NMI monoclonal antibody treatment enhances energy expenditure, protects against DIO, and ameliorates adipose tissue inflammation,
Ting‐Ting Li +7 more
wiley +1 more source
Brown Fat Development in Wild-type and NG2 Null Mice. [PDF]
, 2013 (A–C) Oil Red O staining of IBAT from P5 wild-type (A) and NG2 null (B) mice and quantification of Oil Red O staining intensity (C, n = 6). Bar = 50 µm. D. mRNA levels for brown fat-related genes in IBAT from P5 wild-type and NG2 null mice (n = 3). (E–H)
Zhi-Gang She (334208) +6 more
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Advanced Science, EarlyView.ABSTRACT High‐fat diet (HFD)‐induced hepatic injury represents a pathology observed across vertebrates, yet the underlying mechanisms remain incompletely understood. Herein, the present study identifies phosphatidylethanolamine methyltransferase (Pemt), a key enzyme in phosphatidylcholine synthesis, as a critical regulator of mitochondrial homeostasis ...
Xianyong Bu +11 more
wiley +1 more source
Mir193b-365 is essential for brown fat differentiation [PDF]
, 2011 2012 February 1Mammals have two principal types of fat. White adipose tissue primarily serves to store extra energy as triglycerides, whereas brown adipose tissue is specialized to burn lipids for heat generation and energy expenditure as a defence ...
Mori, Marcelo A. +17 more
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