Results 71 to 80 of about 147,735 (295)

The role of the small intestine in the development of dietary fat-induced obesity and insulin resistance in C57BL/6J mice [PDF]

, 2008
Background Obesity and insulin resistance are two major risk factors underlying the metabolic syndrome. The development of these metabolic disorders is frequently studied, but mainly in liver, skeletal muscle, and adipose tissue.
Mechteld M Grootte Bromhaar, Jansen, Jenny, de Groot Philip J, de Groot, P.J., Hooiveld Guido JEJ, Jansen Jenny, Vermeulen, J.J., Nicole JW de Wit, Jansen, J., Müller, M.R., Bosch-Vermeulen, Hanneke, van der Meer, Roelof, de Wit, Nicole J. W., Meer, R., van der, Bromhaar Mechteld, Wit, N.J.W., de, Philip J de Groot, Bosch-Vermeulen Hanneke, Hooiveld, Guido J. E. J., Müller Michael, Müller, Michael, Grootte Bromhaar, M.M., Michael Müller, de Groot, Philip J., Hanneke Bosch-Vermeulen, de Wit Nicole JW, Roelof van der Meer, de Wit, N.J.W., Bromhaar, Mechteld M. Grootte, van der Meer, R., Jenny Jansen, Groot, P.J., de, Guido JEJ Hooiveld, Hooiveld, G.J.E.J., van der Meer Roelof   +34 more
core   +1 more source

Modulation of miR‐23b Wnt/β‐catenin Axis Strengthens Endothelial Barrier Properties

Advanced Science, EarlyView.
Early blood‐brain barrier (BBB) disruption contributes to stroke and CNS disease pathology. miR‐23b was identified as a regulator of BBB integrity in brain endothelial cells. Inhibition of miR‐23b enhanced barrier‐associated properties, promoted repair‐related signaling, and reduced BBB leakage in experimental stroke models, supporting further ...
Victor Anthony Martinez, Rose E. Presby, Sara Nakanishi, Pallavi Gaur, Ugur Akcan, Johannes Daugaard Krog, Iben Daugaard Krog, Lipi Das, David S. Johnson, Danny Jamoul, Douglas Jury, Brian Lawson, Jacob Körbelin, Lewis M. Brown, Vilas Menon, Dritan Agalliu, Irene Munk Pedersen   +16 more
wiley   +1 more source

Essential role for miR-196a in brown adipogenesis of white fat progenitor cells.

PLoS Biology, 2012
The recent discovery of functional brown adipocytes in adult humans illuminates the potential of these cells in the treatment of obesity and its associated diseases. In rodents, brown adipocyte-like cells are known to be recruited in white adipose tissue
Masaki Mori, Hironori Nakagami, Gerardo Rodriguez-Araujo, Keisuke Nimura, Yasufumi Kaneda   +4 more
doaj   +1 more source

Brown fat thermogenesis in a rat model of dietary obesity [PDF]

, 1987
The effects of chronic feeding of a high-fat diet or a cafeteria-type diet on weight gain and thermogenesis in brown adipose tissue as measured by the binding of a purine nucleotide (guanosine 5'-diphosphate, GDP) to mitochondria of brown adipose tissue
R. A. Schemmel, G. A. Bray, R. D. Wood, J. S. Fisler, J. R. Lupien   +4 more
core   +1 more source

TSPYL5 Promotes Triple‐Negative Breast Cancer Metastasis by Antagonizing USP10‐Mediated PTEN Stabilization to Unleash a ZEB1‐Dependent EMT Program

Advanced Science, EarlyView.
The hyperactivation of PI3K/AKT signaling in PTEN wild‐type triple‐negative breast cancer represents a clinical paradox. We delineate a novel post‐translational regulatory axis wherein the oncogene TSPYL5 competitively antagonizes the deubiquitinase USP10.
Jiaying Shi, Ming Yi, Shengyu Xie, Zhaokun Wang, Xinyue Zhang, Yangwei Zhang, Rui Tang, Yuan Yang, Yunqiang Liu   +8 more
wiley   +1 more source

Brown Adipogenic Reprogramming Induced by a Small Molecule

Cell Reports, 2017
Brown adipose tissue (BAT) has attracted considerable research interest because of its therapeutic potential to treat obesity and associated metabolic diseases.
Baoming Nie, Tao Nie, Xiaoyan Hui, Ping Gu, Liufeng Mao, Kuai Li, Ran Yuan, Jiashun Zheng, Haixia Wang, Ke Li, Shibing Tang, Yu Zhang, Tao Xu, Aimin Xu, Donghai Wu, Sheng Ding   +15 more
doaj   +1 more source

Non-invasive quantification of white and brown adipose tissues and liver fat content by computed tomography in mice. [PDF]

PLoS ONE, 2012
ObjectivesObesity and its distribution pattern are important factors for the prediction of the onset of diabetes in humans. Since several mouse models are suitable to study the pathophysiology of type 2 diabetes the aim was to validate a novel computed ...
Marko Lubura, Deike Hesse, Nancy Neumann, Stephan Scherneck, Petra Wiedmer, Annette Schürmann   +5 more
doaj   +1 more source

Streptavidins Coordinate Biotin Sequestration and Self‐Resistance Within a Biotin‐Pathway Antibiotic Network

Advanced Science, EarlyView.
A conserved genomic region between two streptavidin genes in Streptomyces packages biosynthetic gene clusters for diverse biotin‐pathway antibiotics: acidomycin, stravidin, the new non‐proteinogenic amino acid ANDA, and the new BioA inhibitor α‐methyl‐KAPA.
Sumire Kurosawa, Jingjun Mo, Xiaotong Diao, Feng Xie, Tingting Wang, Haowen Zhao, Dalei Wu, Rolf Müller, Chengzhang Fu   +8 more
wiley   +1 more source

Gene regulatory dynamics underlying brown fat cell differentiation [PDF]

, 2017
Adipose tissue is increasingly recognized as a dynamic, endocrine organ responsible for regulating metabolic homeostasis via the collective action of its two principal subtypes: white adipose tissue (WAT) and brown adipose tissue (BAT).
Pradhan, Rachana Narendra
core   +1 more source

Multi‐Omics Profiling Reveals Immunomodulatory and Pro‐Regenerative Effects of a Graphene Oxide–Collagen Scaffold in Massive Rotator Cuff Tears

Advanced Science, EarlyView.
A graphene oxide/collagen scaffold is developed for chronic massive rotator cuff tear repair. The scaffold improves compressive stability, supports reparative mesenchymal differentiation, and modulates the immune microenvironment. In chronic MRCT models, it reduces muscle degeneration, enhances tendon–bone regeneration, and improves functional recovery,
Renwen Wan, Yechuan Deng, Zixin Hu, Yanwei He, Xinting Feng, Jun Ma, Yisheng Chen, Zhijie Zhao, Jie Mei, Zhiheng Lin, Wei Luo, Zhengyuan Fang, Zhufeng Hu, Kunlun Feng, Xinrong Li, Dan Wu, Bowen Han, James Hoi po Hui, Xuanyong Liu, Chen Chen, Gang Chen, Shiyi Chen, Nirong Bao, Jiajun Qiu, Zhiwen Luo   +24 more
wiley   +1 more source