Results 71 to 80 of about 4,349,521 (358)

Apoptotic and chemotherapeutic properties of iron(III)-salophene in an ovarian cancer animal model [PDF]

, 2008
The cytotoxicity of organometallic compounds iron(III)-, cobalt(III)-, manganese(II)-, and copper(II)-salophene (-SP) on platinum-resistant ovarian cancer cell lines was compared. Fe-SP displayed selective cytotoxicity (IC 50 at ∼1 μM) against SKOV-3 and
Alptürk, O, Brard, L, Kyu, KK, Lange, TS, Luisi, BS, McCourt, C, Singh, AP, Singh, RK, Strongin, RM   +8 more
core   +3 more sources

High LRIG1 expression predicts lymph node metastasis in patients with uterine cervical cancer

FEBS Open Bio, EarlyView.
Lymph node status is crucial in determining treatment for women with early‐stage cervical cancer. We demonstrate that high LRIG1 protein expression in primary tumors can predict lymph node metastases. Our findings support further investigation of LRIG1 as a biomarker to improve staging accuracy and guide treatment decisions in cervical cancer patients.
Pernilla Israelsson, Lisa Lif, Husam Oda, Alexandra Lorenzzi de Melo, David Lindquist, Håkan Hedman   +5 more
wiley   +1 more source

Multiple brown tumors caused by a parathyroid adenoma mimicking metastatic bone disease from giant cell tumor

World Journal of Nuclear Medicine, 2016
Brown tumor affects multiple bones in the body with variable clinical symptoms, which may be misdiagnosed as multiple bone metastases or primary bone tumor.
Rohit Phulsunga, Rahul Parghane, Rajendra Kanojia, Debasis Gochhait, Ashwani Sood, Anish Bhattacharya, Bhagwant Mittal   +6 more
doaj   +1 more source

Synthetic Lethality of Chk1 Inhibition Combined with p53 and/or p21 Loss During a DNA Damage Response in Normal and Tumor Cells [PDF]

, 2013
Cell cycle checkpoints ensure genome integrity and are frequently compromised in human cancers. A therapeutic strategy being explored takes advantage of checkpoint defects in p53-deficient tumors in order to sensitize them to DNA-damaging agents by ...
A Besson, A Eastman, A Goga, A Goloudina, A Z Munir, AA Levesque, AA Levesque, AJ Fikaris, AN Tse, AT Ferguson, B Xu, C Tapia, CJ Sherr, CS Sorensen, CX Ma, EA Kohn, EA Kohn, F Bunz, FI Raynaud, H Piwnica-Worms, H Zhao, I Hassepass, J Bartkova, J Falck, K Shimuta, L S White, LL Parker, MH Lam, MV Cespedes, O Gilad, O Wang, OA Sedelnikova, PM Fracasso, R Di Micco, R Rodriguez, RP Perez, RT Bunch, S Origanti, S-r Cai, SD Zabludoff, T Abbas, T Waldman, WR Taylor, Y Luo   +43 more
core   +2 more sources

Longitudinal Relationship Between Pain and Depression in People With Inflammatory Arthritis: A Narrative Review

Arthritis Care &Research, EarlyView.
As many patients with inflammatory arthritis (IA) have chronic pain, understanding how to best assess and manage pain in IA is a priority. Comorbid depression is prevalent in adults with IA, affecting 15% to 39% of people. Although pain and depression are thought to be associated in IA, this concept is largely based on cross‐sectional data.
Natasha Cox, Saeed Farooq, Helen Twohig, Ian C. Scott   +3 more
wiley   +1 more source

ORAL MANIFESTATION OF RENAL OSTHEODISTROPHY IN CHILDREN

Romanian Journal of Oral Rehabilitation, 2018
Very rare in children, the brown tumor, or osteoclastoma, is an understudied ectopic entity that causes severe debilitation in patients with chronic renal insufficiency.
Iuliana Magdalena Stârcea, Anca Ivanov, Adriana Mocanu, Vasile Valeriu Lupu, Mirabela Subotnicu, Mihaela Munteanu, Ancuţa Ignat, Ingrith Miron   +7 more
doaj  

Use of bone-SPECT/CT and Na[18F]F-PET/CT in hyperparathyroidism

Frontiers in Nuclear Medicine
Hyperparathyroidism disrupts the balance of physiological bone formation and resorption by upregulating osteoclast activity. This leads to hypercalcemia, resulting in osteoporosis and eventually the formation of “brown tumors.” Currently used ...
Wouter van der Bruggen, Bernard F. Bulten   +1 more
doaj   +1 more source

Rare Classic Presentation of Primary Hyperparathyroidism: A Case Report and Literature Review

Open Access Surgery, 2023
Wongel Tena Shale,1 Tolasa Dibisa Jirata,2 Mekbeb Chere Enawgaw,1,3 Ararso Gonfa Metekia,2 Yosef Lemma Kelecha1 1Jimma University College of Public Health and Medical Sciences, Department of Surgery, Jimma University, Jimma, Oromia, Ethiopia; 2Jimma ...
Shale WT, Jirata TD, Enawgaw MC, Metekia AG, Kelecha YL   +4 more
doaj  

Activated lymphocyte recruitment into the tumor microenvironment following preoperative sipuleucel-T for localized prostate cancer. [PDF]

, 2014
BackgroundSipuleucel-T is a US Food and Drug Administration-approved immunotherapy for asymptomatic or minimally symptomatic metastatic castration-resistant prostate cancer (mCRPC). Its mechanism of action is not fully understood.
Amling, Christopher L, Carroll, Peter, Chan, Stephen, Corman, John, Fong, Lawrence, Frohlich, Mark W, Lewis, Jera, Sheikh, Nadeem A, Simko, Jeffrey, Sims, Robert B, Small, Eric J, Stephenson, Robert A, Weinberg, Vivian   +12 more
core   +2 more sources

Management challenges with brown tumor of primary hyperparathyroidism masked by severe vitamin D deficiency: a case report

Journal of Medical Case Reports, 2016
BackgroundHyperparathyroidism is a disease characterized by excessive secretion of parathyroid hormone, the hormone responsible for calcium and phosphate homeostasis in the body. It can be of three types: primary, secondary, or tertiary.
Marya Hussain, M. Hammam
semanticscholar   +1 more source