Results 51 to 60 of about 32,043 (255)

Antibiotic persistence of intracellular Brucella abortus

PLOS Neglected Tropical Diseases, 2022
Background Human brucellosis caused by the facultative intracellular pathogen Brucella spp. is an endemic bacterial zoonosis manifesting as acute or chronic infections with high morbidity. Treatment typically involves a combination therapy of two antibiotics for several weeks to months, but despite this harsh treatment relapses occur at a rate of 5–15%
Selma Mode, Maren Ketterer, Maxime Québatte, Christoph Dehio   +3 more
openaire   +5 more sources

Mitochondrial fusion protein 2 affects intracellular survival of brucella abortus a19 by regulating endoplasmic reticulum stress and apoptosis [PDF]

Kafkas Universitesi Veteriner Fakültesi Dergisi
Mitochondrial fusion protein 2 (MFN2) deficiency has been shown to hinder the survival of bacteria in macrophages. Endoplasmic reticulum stress and apoptosis are vital defense mechanisms against Brucella infection, but the specific role of MFN2 in ...
Zhenyu XU, Qin YANG, Xiaoyu DENG, Yimei XU, Zhongchen MA, Chuangfu CHEN   +5 more
doaj   +1 more source

Brucellosis remains a neglected disease inthe developing world: a call forinterdisciplinary action [PDF]

, 2018
Brucellosis places significant burdens on the human healthcare system and limits the economic growth of individuals, communities, and nations where such development is especially important to diminish the prevalence of poverty.
A Fournier, A Gregoire, A. M. Arenas-Gamboa, AH Al-Talafhah, AM Arenas-Gamboa, AS Dean, AS Dean, B Megersa, B Schumaker, B. N. Häsler, BB Asiimwe, BB Singh, C Jo, CW Cooper, D Grace, D Merriott, E Herrera, E Moreno, EL Prado, F Roth, FF Tuon, FP Poester, G Vilchez, II Musallam, J Godfroid, J McDermott, J Rushton, J Zinsstag, JA Assenga, JJ McDermott, K Pedersen, K. A. Franc, MN Seleem, NE Lucero, O Vered, P Chand, PH Bamaiyi, R Strasser, R. C. Krecek, S Kose, SC Olsen, SC Welburn, SS Mandal, TR Kelly, TW Roberts, V Racloz, YM Hegazy   +46 more
core   +1 more source

Structural Analysis and Inhibitor Modeling of Bacterioferritin From Brucella abortus

Proteins: Structure, Function, and Bioinformatics, EarlyView.
ABSTRACT Iron homeostasis in various pathogenic bacteria is regulated by bacterioferritins (Bfr) which function to store Fe3+ and release Fe2+ as needed for metabolic processes. The Bfr structure consists of 18 kDa subunits in which dimer pairs bind a heme molecule and are assembled into a highly symmetrical 24‐meric spherical structure with an ...
Lijun Liu, Elizabeth K. Harmon, Justin K. Craig, Huili Yao, Kevin P. Battaile, David K. Johnson, Sandhya Subramanian, Wesley C. Van Voorhis, Mario Rivera, Scott Lovell   +9 more
wiley   +1 more source

A lysozyme-like protein in Brucella abortus is involved in the early stages of intracellular replication [PDF]

, 2013
Secretion of proteins in Gram-negative bacteria is a high-energy consuming process that requires the translocation across two membranes and a periplasmic space composed of a mesh like layer, the peptidoglycan.
Czibener, Cecilia, del Giudice, Mariela Giselda, Ugalde, Juan Esteban   +2 more
core   +1 more source

Serological and molecular detection of bovine brucellosis at institutional livestock farms in Punjab, Pakistan [PDF]

, 2020
Bovine brucellosis remains a persistent infection in ruminants in Pakistan. A total of 828 (409 buffaloes and 419 cattle) sera were collected from 11 institutional-owned livestock farms in Punjab, Pakistan.
Hussain, Muhammad Hammad, Jamil, Tariq, Kasi, Khushal Khan, Khan, Iahtasham [u.v.m.], Melzer, Falk, Rashid, Imaad, Saqib, Muhammad, Schwarz, Stefan, Shahzad, Asim, Tahir, Usman   +9 more
core   +1 more source

Brucella abortus Endocarditis [PDF]

Circulation, 1957
The diagnosis and successful treatment of a case of bacterial endocarditis due to Brucella abortus is described. Therapy consisted of the combination of aureomycin and streptomycin.
openaire   +2 more sources

Recent advances in Brucella abortus vaccines [PDF]

Veterinary Research, 2015
Brucella abortus vaccines play a central role in bovine brucellosis control/eradication programs and have been successfully used worldwide for decades. Strain 19 and RB51 are the approved B. abortus vaccines strains most commonly used to protect cattle against infection and abortion.
Dorneles, Elaine M. S., Sriranganathan, Nammalwar, Lage, Andrey P.   +2 more
openaire   +4 more sources

Fatal spinal cord compression in a horse with chronic actinobacterial cranial nuchal bursitis

Equine Veterinary Education, EarlyView.
Summary A 14‐year‐old warmblood gelding was managed for waxing and waning cranial nuchal bursitis for 2 years. Intensive medical and surgical management was not curative, and the patient was subjected to euthanasia after becoming acutely recumbent. Ante‐mortem and post‐mortem next generation sequencing of bursal tissue and post‐mortem conventional PCR ...
H. Mesch, C. Frank, J. B. Daniels, E. Acutt, E. Contino   +4 more
wiley   +1 more source

16- DETECTION OF BRUCELLA SPECIES IN APPARENTLY HEALTHY COWS AND GOATS RAW MILK BY PCR [PDF]

Basrah Journal of Veterinary Research, 2018
Brucellosis an intracellular pathogen capable of infecting animals and humans. The aim of this study was to identify Brucella spp in apparently healthy cow and goat raw milk samples by a polymerase chain reaction (PCR)-based method.
Fawzia A. Abdullah, Enas Ismael Al- Jaboury   +1 more
doaj   +1 more source