Mitochondrial fusion protein 2 affects intracellular survival of brucella abortus a19 by regulating endoplasmic reticulum stress and apoptosis [PDF]
Kafkas Universitesi Veteriner Fakültesi DergisiMitochondrial fusion protein 2 (MFN2) deficiency has been shown to hinder the survival of bacteria in macrophages. Endoplasmic reticulum stress and apoptosis are vital defense mechanisms against Brucella infection, but the specific role of MFN2 in ...
Zhenyu XU +5 more
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16- DETECTION OF BRUCELLA SPECIES IN APPARENTLY HEALTHY COWS AND GOATS RAW MILK BY PCR [PDF]
Basrah Journal of Veterinary Research, 2018 Brucellosis an intracellular pathogen capable of infecting animals and humans. The aim of this study was to identify Brucella spp in apparently healthy cow and goat raw milk samples by a polymerase chain reaction (PCR)-based method.
Fawzia A. Abdullah +1 more
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Integrating serological and genetic data to quantify cross-species transmission: brucellosis as a case study [PDF]
, 2016 Epidemiological data are often fragmented, partial, and/or ambiguous and unable to yield the desired level of understanding of infectious disease dynamics to adequately inform control measures.
Buza, Joram J. +8 more
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Effects of live Brucella abortus strain 19 vaccine on reindeer
Rangifer, 1989 Twenty female and seven male reindeer (Rangifer tarandus) were vaccinated subcutaneously in the right shoulder with a 1-ml dose of approximately 1.2 x 108 colony forming units of Brucella abortus strain 19, the standard reduced dose for cattle.
Robert A. Dieterich, Jamie K. Morton
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Frontiers in Immunology, 2018 Brucella abortus is a Gram-negative intracellular bacterium that causes a worldwide zoonosis termed brucellosis, which is characterized as a debilitating infection with serious clinical manifestations leading to severe complications.
P. P. Corsetti +6 more
semanticscholar +1 more source
Antigen-specific acquired immunity in human brucellosis: implications for diagnosis, prognosis, and vaccine development. [PDF]
, 2012 Brucella spp., are Gram negative bacteria that cause disease by growing within monocyte/macrophage lineage cells. Clinical manifestations of brucellosis are immune mediated, not due to bacterial virulence factors.
Alessandro eSette +8 more
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Molecular Microbiology, EarlyView.The HWE‐family histidine kinase PhyK regulates the cell envelope structure of the intracellular pathogen Brucella ovis and affects how the host immune system responds to this bacterium. Deletion of phyK alters bacterial survival in the face of detergent stress and reduces immune activation in infected macrophages.
Xingru Chen +6 more
wiley +1 more source
Regulation of Brucella abortus Catalase [PDF]
Infection and Immunity, 2000 ABSTRACT All aerobic organisms have mechanisms that protect against oxidative compounds. Catalase, peroxidase, superoxide dismutase, glutathione, and thioredoxin are widely distributed in many taxa and constitute elements of a nearly ubiquitous antioxidant metabolic strategy.
John E. Mayfield +2 more
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Interleukin 10 suppresses lysosome-mediated killing of Brucella abortus in cultured macrophages
Journal of Biological Chemistry, 2018 Brucella abortus is a Gram-negative zoonotic pathogen for which there is no 100% effective vaccine. Phagosomes in B. abortus–infected cells fail to mature, allowing the pathogen to survive and proliferate. Interleukin 10 (IL10) promotes B.
H. T. Hop +8 more
semanticscholar +1 more source
COMPARISON OF SEROLOGICAL INTERFERENCE FOLLOWING VACCINATION WITH BRUCELLA AB~RTUS STRAINS I N ROUTINE DIAGNOSTIC TESTS [PDF]
Journal of Veterinary and Animal Sciences, 2007 The serological interference following Brucella aborfus SR851 and S99 vaccination, in routine diagnostic tests was evaluafed in catf/e of four months and above. Sero negative animals were grouped into three.
K. N. Nimisha +4 more
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