Results 41 to 50 of about 9,222 (174)

Prognostic Value of Small Coved‐Type ST‐Segment Area in Patients With Spontaneous Type 1 Brugada Syndrome

Journal of Cardiovascular Electrophysiology, EarlyView.
Electrical and structural abnormalities in Brugada syndrome lead to a smaller coved‐type ST‐segment area. A reduced ST‐segment area may identify patients at elevated risk of ventricular fibrillation. ABSTRACT Background Risk stratification in Brugada syndrome (BrS) remains challenging.
Nario Sano, Tetsuji Shinohara, Keisuke Yonezu, Masaki Takahashi, Hirochika Yamasaki, Kei Hirota, Hidekazu Kondo, Akira Fukui, Hidefumi Akioka, Yasushi Teshima, Naohiko Takahashi   +10 more
wiley   +1 more source

Supraventricular tachyarrhythmia in patients with Brugada syndrome: A single-center study

Journal of Arrhythmia, 2013
Background: Brugada syndrome is a distinct form of idiopathic ventricular fibrillation. We retrospectively investigated the incidence and clinical implications of supraventricular tachyarrhythmia in patients with Brugada syndrome. Methods: We reviewed 69
Kimie Ohkubo, Ichiro Watanabe, Yasuo Okumura, Masayoshi Kofune, Koichi Nagashima, Hiroaki Mano, Kazumasa Sonoda, Toshiko Nakai, Satoshi Kunimoto, Yuji Kasamaki, Atsushi Hirayama, Naokata Sumitomo, Tomohiro Nakayama   +12 more
doaj   +1 more source

Glycosylation of the murine cardiac channel TRPM4 is altered by the pathogenic p.I376T variant

Experimental Physiology, EarlyView.
Abstract TRPM4 is a calcium‐activated, voltage‐modulated, non‐selective cation channel expressed in various tissues, including the heart. In 2016, we reported on a large French family with progressive heart block type I carrying the variant TRPM4 p.I376T.
Sabrina Guichard, Emanuele di Lorenzo, Dominic Schneiter, Maria Essers, Prakash Arullampalam, Jean‐Sébastien Rougier, Hugues Abriel   +6 more
wiley   +1 more source

In silico modelling of multi‐electrode arrays for enhancing cardiac drug testing on hiPSC‐CM heterogeneous tissues

The Journal of Physiology, EarlyView.
Abstract figure legend Schematic overview of the experimental and computational framework for investigating hiPSC‐CM electrophysiology with MEA systems. The MEA‐based model integrates experimental data with phenotype‐specific ionic models and tissue‐level heterogeneity.
Sofia Botti, Rolf Krause, Luca F. Pavarino   +2 more
wiley   +1 more source

Brugada Syndrome 2012

Circulation Journal, 2012
Brugada syndrome (BS) is a cardiac disorder characterized by typical ECG alterations, and it is associated with a high risk for sudden cardiac death (SCD), affecting young subjects with structurally normal hearts. The prevalence of this disorder is still uncertain, presenting marked geographical differences.
Paola, Berne, Josep, Brugada
openaire   +3 more sources

Caenorhabditis elegans as an in vivo model system for human inherited primary arrhythmia syndromes

The Journal of Physiology, EarlyView.
Abstract figure legend Most genes involved in inherited primary arrhythmia syndromes (IPAS) are conserved in Caenorhabditis elegans, where genetic manipulation enables functional characterization of variants, identification of regulatory proteins, and in vivo drug testing.
Antoine Delinière, Thomas Boulin, Maëlle Jospin, Alexandre Janin, Gilles Millat, Philippe Chevalier, Olga Andrini   +6 more
wiley   +1 more source

Translating cardiovascular ion channel and Ca2+ signalling mechanisms into therapeutic insights

The Journal of Physiology, EarlyView.
Abstract figure legend This white paper integrates mechanistic discoveries across ion channel biology, Ca2+ signalling and multiscale cardiovascular physiology to highlight new opportunities for accelerating research and guiding next‐generation therapies. Printed with permission from ®Anita Impagliazzo Medical Illustration. [Correction added on 2 March
Silvia Marchianò, Miguel Martín‐Aragón Baudel, Charlotte E. R. Smith, Gonzalo Hernandez Hernandez, Donald M. Bers, Patrick M. Boyle, Dobromir Dobrev, Shanna Hamilton, Osama F. Harraz, Na Li, Thomas A. Longden, William E. Louch, Madeline Nieves‐Cintron, Matthew A. Nystoriak, Walter Lee Murfee, Przemysław B. Radwański, Swapnil K. Sonkusare, Manuel F. Navedo, Eleonora Grandi   +18 more
wiley   +1 more source

Case Report: Lurasidone-Induced Type 2 Brugada Pattern in a Pediatric Patient

Clinical Practice and Cases in Emergency Medicine
Introduction: Brugada syndrome, a cardiac channelopathy, manifests with ventricular arrhythmia. Diagnosis relies on a type 1 Brugada electrocardiogram (ECG) pattern, while type 2 and type 3 patterns may necessitate electrophysiologic testing to uncover ...
Ethan Start, Aldrin Enabore
doaj   +1 more source

Analysis of a Family with Brugada Syndrome and Sudden Cardiac Death Caused by a Novel Mutation of SCN5A

Cardiology Research and Practice, 2022
Background. Brugada syndrome is a hereditary cardiac disease associated with mutations in ion channel genes. The clinical features include ventricular fibrillation, syncope, and sudden cardiac death.
Yao-Bin Zhu, Jian-Hui Zhang, Yuan-Yuan Ji, Ya-Nan Hu, Han-Lu Wang, Dan-Dan Ruan, Xiao-Rong Meng, Xin-Fu Lin, Jie-Wei Luo, Wei Chen   +9 more
doaj   +1 more source

Brugada Syndrome: New Implications for Heterozygous Carriers of the Pathogenic SCN5A c.689T>C(p.Ile230Thr) Variant

American Journal of Medical Genetics Part A, Volume 200, Issue 5, Page 1083-1086, May 2026.
ABSTRACT Pathogenic variants in the SCN5A gene and its subunits have been identified in individuals with Brugada Syndrome. One such SCN5A variant, c.689T>C(p.Ile230Thr), was previously reported as disease‐causing only in homozygous individuals, with heterozygous carriers being unaffected.
Shayla Shojaat, Benjamin Hale, Taylor Warner   +2 more
wiley   +1 more source