Results 51 to 60 of about 9,222 (174)

Fever Unmasked Brugada Syndrome in Pediatric Patient: A Case Report

Clinical Practice and Cases in Emergency Medicine, 2020
Introduction: Brugada syndrome is an arrhythmogenic disorder that is a known cause of sudden cardiac death. It is characterized by a pattern of ST segment elevation in the precordial leads on an electrocardiogram (EKG) due to a sodium channelopathy. Case
Orhay Mirzapolos, Perry Marshall, April Brill   +2 more
doaj   +1 more source

An open‐label, single‐arm, dose‐escalating concentration–QT study to investigate the cardiac effects and safety of paroxetine in healthy adults

British Journal of Clinical Pharmacology, Volume 92, Issue 5, Page 1385-1396, May 2026.
Abstract Aims Paroxetine is a selective serotonin reuptake inhibitor (SSRI), approved for treatment of major depressive disorder and anxiety disorders. Some SSRIs are known to prolong the QT interval; however, clinical evidence to establish a lack of association between paroxetine and corrected QT interval (QTc) prolongation is limited. Therefore, this
Sven C. van Dijkman, Mathieu Félices, Bhaskar Pandurangavittal, Sanman Ghorpade, Caroline Easterbrook, Marcin Zabielski, Oscar Della Pasqua   +6 more
wiley   +1 more source

Alternative Lead ECG Placements

Annals of Noninvasive Electrocardiology, Volume 31, Issue 3, May 2026.
Alternative ECG lead placements can improve diagnostic yield when the standard 12‐lead ECG is suboptimal or infeasible. This review summarizes practical, scenario‐driven modifications (right‐sided, posterior, seated/prone, Lewis, Fontaine, torso‐based, and monitoring configurations) to better detect ischemia, right ventricular disease/ARVD, and ...
José Luis Morales‐Arteaga, Amin Meghdadi, Derek Wu, Abdullah Bhuiyan, Nicole Langleben, Cengiz Burak, Emily Wilson, Ashley Pellerito, David Aristizábal, Keanu Razzaghi, Juan Maria Farina, Shyla Gupta, Adrian Baranchuk   +12 more
wiley   +1 more source

Population‐Based Study Found Low Risk of Misdiagnosing Long QT Syndrome as Breath‐Holding Spells in Swedish Children

Acta Paediatrica, Volume 115, Issue 5, Page 1116-1125, May 2026.
ABSTRACT Aim An electrocardiogram is commonly recommended in breath‐holding spell management, mainly to rule out long QT syndrome. This retrospective study investigated the risk of long QT syndrome being misdiagnosed as breath‐holding spells in a paediatric population in southern Sweden.
Sanna Hellström Schmidt, Ida Jeremiasen, Erik A. Eklund, Cornelis Jan Pronk   +3 more
wiley   +1 more source

Alcohol-induced Ventricular Fibrillation in Brugada Syndrome

Journal of Arrhythmia, 2009
A 37-year-old man lost consciousness suddenly due to ventricular fibrillation (VF). After cardioversion, twelve-lead ECG showed a pattern characteristic of type 1 Brugada. An implantable cardioverter defibrillator (ICD) was implanted for Brugada syndrome.
Takekuni Hayashi, MD, Haruo Mitani, MD, Kosaku Goto, MD, Rieko Ishimura, MD, Susumu Tao, MD, Sachiko Ito, MD, Jun Masuda, MD, Hajime Fujimoto, MD, Yo Fujimoto, MD, Sugao Ishiwata, MD, Tetsu Yamaguchi, MD, Minoru Ohno, MD   +11 more
doaj   +1 more source

A Case of STEMI Masquerading Brugada Syndrome: Emphasizing the Importance of Clinical Decision Making in Emergencies

Journal of Investigative Medicine High Impact Case Reports, 2021
Brugada syndrome is a rare arrhythmogenic syndrome that is associated with an increased risk of ventricular fibrillation and sudden cardiac death. Electrocardiographic findings include patterns similar to a right bundle branch block (RBBB) and persistent
Nirmal Guragai MD, Rahul Vasudev MD, Dhaval Shah MD, Balraj Singh MD, Parminder Kaur MD, Ashen Fernando MD, Fayez Shamoon MD, Raja Pullatt MD, Meherwan Joshi MD, Preet Randhawa MD   +9 more
doaj   +1 more source

Connexin43 Deficiency Leads to Ventricular Arrhythmias by Reprogramming Proline Metabolism

Advanced Science, Volume 13, Issue 19, 2 April 2026.
The study demonstrated that connexin43 (Cx43) knockout caused arrhythmic phenotype and decreased proline content in vitro and in vivo. Mechanistically, Cx43 interacts with the amino acid transporter SNAT2 (sodium‐dependent neutral amino acid transporter), and its deficiency disrupts proline transport and metabolism.
Hangying Ying, Hangping Fan, Yunhe Wang, Ruhong Jiang, Dongsheng Cai, Hui Cheng, Hao Wang, Chenyang Jiang, Ping Liang   +8 more
wiley   +1 more source

Treatment of Anxiety and Depression in a Patient with Brugada Syndrome

Case Reports in Psychiatry, 2014
Background. Brugada syndrome is rare and has been a clinically diagnosable entity since 1992. Its clinical manifestations are highly variable, and while some patients remain asymptomatic, others endure sudden cardiac death.
Jasper J. Chen, Rajbir S. Sangha
doaj   +1 more source

Propofol‐Related Infusion Syndrome in Paediatrics—Cautious Consideration or Considered Caution? Case Report

Journal of Paediatrics and Child Health, EarlyView.
Michael A. Stokes, Mark A. J. Dexter, Stephen Jacobe, Jonathan R. Egan, Cindy G. Berrueta Rodriguez, Ashfaque Quadir   +5 more
wiley   +1 more source

Calcium Channel Blockers Inhibit Pancreatic Neuroendocrine Neoplasms Progression via Cav1.2‐Epigenetic Circuit

Advanced Science, Volume 13, Issue 20, 9 April 2026.
Our study reveals a novel mechanism of a positive regulatory circuit between Cav1.2 and H3K27ac for pancreatic neuroendocrine neoplasms (pNENs) progression. Cav1.2 is identified as a crucial target for promoting disease progression and correlates with malignant behaviors, which are remarkably inhibited by the administration of calcium channel blockers (
Yangyinhui Yu, Qiongcong Xu, Jinzhao Xie, Mingjian Ma, Xitai Huang, Yinhao Shi, Jiawei Zhou, Enliang Zhu, Ziyi Zhao, Ning Zhang, Zhide Liu, Jingyuan Ye, Xiaoyu Yin   +12 more
wiley   +1 more source