Bruton’s Tyrosine Kinase Inhibition for the Treatment of Rheumatoid Arthritis
ImmunoTargets and Therapy, 2021 Laura C Arneson,1,* Kristen J Carroll,1,* Eric M Ruderman2 1Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA; 2Department of Medicine, Division of Rheumatology, Northwestern University Feinberg School ...
Arneson LC, Carroll KJ, Ruderman EM
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Profound Sinoatrial Arrest Associated with Ibrutinib
Case Reports in Oncological Medicine, 2017 Background. Ibrutinib is a Bruton’s tyrosine kinase (BTK) inhibitor approved for second-line treatment for mantle cell lymphoma (MCL), chronic lymphocytic leukemia (CLL), and Waldenström macroglobulinemia.
Kanupriya Mathur +3 more
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Regulatory Mechanism of PTP-PEST for IgE Fc Receptor Signaling [PDF]
, 2010 連続したくしゃみ、止まらない鼻水などやっかいな症状で悪名の高い所謂「アレルギー」を直接引き起こす細胞は、マスト細胞もしくは好塩基球である。マスト細胞は、IgE 受容体 (FcεR) を介して活性化され、顆粒中に蓄えた炎症物質放出と炎症性サイトカインの合成・放出によりアレルギー性炎症を惹起する。この細胞内シグナル伝達において、種々のタンパク質中のチロシンリン酸化と脱リン酸化制御が重要な働きをしている。我々は、以前、マスト細胞のFcεRシグナルにおける各種チロシン脱リン酸化酵素(PTP ...
片桐 達雄, 鈴木 望美
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The expression and signalling patterns of CD180 toll like receptor in Chronic Lymphocytic Leukaemia (CLL) [PDF]
, 2019 Chronic lymphocytic leukaemia (CLL) is characterised by a progressive accumulation of mature CD5+CD20+CD23+ lymphocytes. Despite the remarkable progress in our understanding of the immunobiology of CLL, the aetiology of the disease remains unknown.
Sayed, U., Sayed, U.
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Isoform of Bruton's tyrosine kinase (BTK) protein
, 2008 The use of compounds is described which are capable of functionally blocking at least one of the genes chosen from the group composed of EphA1, EphA2, EphA8, EphB2, CSF1R, VEGFR2, RAMP2, RAMP3, CLRN1, MAPK4, PIK3C2A, PIK3CG, GSK3alpha, GSK3beta, IRAK3, DAPK1, JAK1, PIM1, TRB3, BTG1, LATS1, LIMK2, MYLK, PAK1, PAK2, CDC2, BTK, PNRC2, NCOA4, NR2C1, TPR ...
LAVITRANO, MARIALUISA +2 more
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Novel Bruton's tyrosine kinase inhibitors currently in development.
OncoTargets and therapy, 2013 Bruton's tyrosine kinase (Btk) is intimately involved in multiple signal-transduction pathways regulating survival, activation, proliferation, and differentiation of B-lineage lymphoid cells. Btk is overexpressed and constitutively active in several B-lineage lymphoid malignancies.
D’Cruz, Osmond J, Uckun, Fatih M
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INCREASED SURVIVAL OF CLL B CELLS IN THE PRESENCE OF MARROW MESENCHYMAL STROMAL CELLS: A NOVEL MODEL TO DEFINE NEW TARGETS FOR THERAPY [PDF]
, 2016 Chronic Lymphocytic Leukemia (CLL) is the most common leukemia in the Western World, accounting for about 30% of adult leukemia, and it is characterized by the clonal expansion and accumulation of mature CD19+/CD5+/CD23+ B lymphocytes in the peripheral ...
CASTELLI, MONICA
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Involvement of Bruton's tyrosine kinase in FcepsilonRI-dependent mast cell degranulation and cytokine production. [PDF]
, 1998 We investigated the role of Bruton's tyrosine kinase (Btk) in FcepsilonRI-dependent activation of mouse mast cells, using xid and btk null mutant mice.
Alt, FW +16 more
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Profound reduction of mature B cell numbers, reactivities and serum lg levels in mice which simultaneously carry the XID and CD40 deficiency gense [PDF]
, 2017 It has been known for some time that single mutant nude or CD40T mice have apparently normal numbers of cells in the precursor compartments of bone marrow and the mature B cell compartments of the periphery.
Andersson, Jan +8 more
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Functional interaction between CD180 Toll-like receptor (TLR) and B cell receptor (BCR) in the biology of Chronic Lymphocytic Leukaemia (CLL) [PDF]
, 2017 Chronic Lymphocytic Leukaemia (CLL) is the most common leukaemia in the western world and remains incurable. It is driven by as yet unknown (auto)antigens via the B cell receptor (BCR) and growth, survival and expansion signals it receives from the ...
Rajakaruna, A., Rajakaruna, A.
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