Results 161 to 170 of about 7,553 (206)

Bruton’s Tyrosine Kinase in Ankylosing Spondylitis

Spine, 2023
Study Design. Prospective case-control study. Objective. To explore the role of Bruton’s tyrosine kinase (BTK) in ankylosing spondylitis (AS). Summary of Background Data.
Hsien-Tzung, Liao, Chun-Hsiung, Chen
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Signalling of Bruton's Tyrosine Kinase, Btk

Scandinavian Journal of Immunology, 1999
Bruton's tyrosine kinase, which is encoded by the BTK gene, is a cytoplasmic protein tyrosine kinase (PTK) crucial for B‐cell development and differentiation. It belongs to the Tec family of PTKs containing several domains that are characteristic of signalling molecules.
A J, Mohamed, B F, Nore, B, Christensson, C I, Smith   +3 more
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Bruton Tyrosine Kinase Degraders

American Journal of Clinical Oncology
Bruton tyrosine kinase (BTK) is a key enzyme involved in B-cell development and signaling, making it a crucial target in the treatment of B-cell malignancies, such as chronic lymphocytic leukemia and non-Hodgkin lymphoma. While BTK inhibitors (BTKi), such as ibrutinib, have been effective, resistance—both intrinsic and acquired—poses a significant ...
Giorgi, Sabakhtarishvili, Mouza, Alshebli, Omer, Bajwa, Imad A, Tabbara   +3 more
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Bruton tyrosine kinase inhibitor ibrutinib (PCI-32765)

Leukemia & Lymphoma, 2013
Over the past 3 years, ibrutinib (PCI-32765) has emerged as a breakthrough in targeted therapy for patients with certain types of B cell malignancies. Early stage clinical trials found ibrutinib to be particularly active in chronic lymphocytic leukemia (CLL) and mantle cell lymphoma (MCL), providing the rationale for ongoing phase 3 trials. In contrast
Jan A, Burger, Joseph J, Buggy
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Bruton's Tyrosine Kinase (Btk)

2012
Bruton's tyrosine kinase (Btk) is a non-receptor tyrosine kinase belonging to the Tec family of kinases. Btk is critical for B-cell development, differentiation and signalling through the B-cell antigen receptor (BCR) as is evident by its genetic association to a human primary immunodeficiency disease known as X-linked Agammaglobulinemia (XLA).
MARK E. SCHNUTE, ADRIAN HUANG, EDDINE SAIAH   +2 more
openaire   +1 more source

Cardiovascular Toxicities of Bruton’s Tyrosine Kinase Inhibitors

Current Treatment Options in Oncology, 2020
There has been a significant shift in the management of B cell malignancies over the past decade. Initial strategies involving the use of systemic chemotherapies have been gradually replaced by more targeted therapies to improve survival and overall tolerability.
Ricardo, Pineda-Gayoso, Mohammed, Alomar, Dae Hyun, Lee, Michael G, Fradley   +3 more
openaire   +2 more sources

Role of Bruton's tyrosine kinase in immunodeficiency

Current Opinion in Immunology, 1994
The genetic defect associated with human X-linked agammaglobulinemia and murine X-linked immunodeficiency was recently shown to result from lack of function of a new cytoplasmic tyrosine kinase, called Bruton's tyrosine kinase (Btk). The phenotypes associated with these immunodeficiencies indicate that Btk plays a critical role in B-lymphocyte ...
S, Tsukada, D J, Rawlings, O N, Witte
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Bruton tyrosine kinase (Btk) suppresses osteoblastic differentiation

Journal of Bone and Mineral Metabolism, 2014
The Tec family of nonreceptor tyrosine kinases has been shown to play a key role in inflammation and bone destruction. Bruton tyrosine kinase (Btk) has been the most widely studied because of its critical role in B cells. Furthermore, recent evidence has demonstrated that blocking Btk signaling is effective in ameliorating lymphoma progression and ...
Shoichi, Kaneshiro, Kosuke, Ebina, Kenrin, Shi, Kiyoshi, Yoshida, Dai, Otsuki, Hideki, Yoshikawa, Chikahisa, Higuchi   +6 more
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Bruton’s tyrosine kinase (Btk)—the critical tyrosine kinase in LPS signalling?

Immunology Letters, 2004
The discovery of the Toll-like receptors (TLRs) has revolutionised the field of innate immunity. One unresolved question regarding LPS signalling is whether there is a role for tyrosine kinases downstream of the LPS receptor. Studies in mice deficient in Bruton's tyrosine kinase have previously shown that they are defective in their responses to LPS ...
Caroline A, Jefferies, Luke A J, O'Neill
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X-Linked Agammaglobulinemia and Bruton’s Tyrosine Kinase

1994
The genetic defect associated with human X-linked agammaglobulinemia (XLA) and murine X-linked immunodeficiency (XID) was recently identified as the deficiency of function of a new cytoplasmic tyrosine kinase called Bruton’s tyrosine kinase (Btk)1,2,3,4. The phenotypes associated with these immunodeficiencies indicate that Btk plays a crucial role in B
S, Tsukada, O N, Witte
openaire   +2 more sources