Results 171 to 180 of about 178,517 (322)

Rilzabrutinib for the Treatment of Immune Thrombocytopenia

European Journal of Haematology, Volume 115, Issue 1, Page 4-15, July 2025.
ABSTRACT Advancements in the understanding of ITP pathogenesis have led to significant improvements in disease management through the use of both traditional immunosuppressive strategies and novel targeted therapies. However, a subset of patients remains refractory to treatment or achieves only transient benefits, underscoring the need for alternative ...
Caterina Labanca, Enrica Antonia Martino, Ernesto Vigna, Antonella Bruzzese, Francesco Mendicino, Giulio Caridà, Eugenio Lucia, Virginia Olivito, Veronica Manicardi, Nicola Amodio, Antonino Neri, Fortunato Morabito, Massimo Gentile   +12 more
wiley   +1 more source

G Protein βγ Subunits Act on the Catalytic Domain to Stimulate Bruton's Agammaglobulinemia Tyrosine Kinase [PDF]

, 2002
William E. Lowry, Xin‐Yun Huang
openalex   +1 more source

Follicle on the Roof: Tertiary Lymphoid Structures in Central Nervous System Autoimmunity

Immunological Reviews, Volume 332, Issue 1, July 2025.
ABSTRACT Leptomeningeal tertiary lymphoid structures (TLS) have emerged as a relatively common pathological feature of autoimmune disease, including multiple sclerosis (MS) and particularly in people with progressive and nonremitting MS. These ectopic lymphoid aggregates, observed in the leptomeninges adjacent to so‐called “Type 3” sub‐pial cortical ...
Michelle Zuo, Angela A. Wang, Jennifer L. Gommerman   +2 more
wiley   +1 more source

QSAR modelling, molecular docking, molecular dynamic and ADMET prediction of pyrrolopyrimidine derivatives as novel Bruton’s tyrosine kinase (BTK) inhibitors

Saudi Pharmaceutical Journal
In recent years, there has been a focus on developing and discovering novel Bruton's tyrosine kinase (BTK) inhibitors, as they offer an effective treatment strategy for B-cell malignancies.
Mourad Aloui, Mohammed Er-rajy, Hamada Imtara, Amina Goudzal, Sara Zarougui, Mohamed El fadili, David E. Arthur, Ramzi A. Mothana, Omar M. Noman, Mahmoud Tarayrah, Elhalaoui Menana   +10 more
doaj  

Identification of mutations of Bruton's tyrosine kinase gene (BTK) in Brazilian patients with X-linked agammaglobulinemia [PDF]

, 2002
Sergio Massayuki Tani, Yue Wang, Hirokazu Kanegane, Takeshi Futatani, Jorge Pinto, Maria Marluce dos Santos Vilela, Toshio Miyawaki   +6 more
openalex   +1 more source

Involvement of Bruton's tyrosine kinase in FcepsilonRI-dependent mast cell degranulation and cytokine production. [PDF]

, 1998
We investigated the role of Bruton's tyrosine kinase (Btk) in FcepsilonRI-dependent activation of mouse mast cells, using xid and btk null mutant mice.
Alt, FW, Galli, SJ, Goldfeld, AE, Han, W, Hartman, SE, Hata, D, Inagaki, N, Kawakami, T, Kawakami, Y, Khan, WN, Kitamura, T, Lantz, CS, Maeda-Yamamoto, M, Miura, T, Nagai, H, Witte, ON, Yao, L   +16 more
core  

Trajectories of allergic diseases in children: Destination unknown?

Pediatric Allergy and Immunology, Volume 36, Issue 7, July 2025.
Abstract The trajectories of allergic diseases represent one of the most currently debated topics both when referred to childhood and likewise adulthood. Data from cohorts show their heterogeneity as well as the key role of genetic and environmental factors.
Birgit Kalb, Ekaterina Khaleva, Mattia Giovannini, Karine Adel‐Patient, Flore Amat, Stefania Arasi, Susanne Lau, Antonio Nieto, Bianca Schaub, Marie Standl, Jonathan O'B Hourihane, Philippe Eigenmann, Antoine Deschildre, on behalf of the EAACI‐Clemens von Pirquet Foundation   +13 more
wiley   +1 more source

Bruton's Tyrosine Kinase Is Required For Lipopolysaccharide-induced Tumor Necrosis Factor α Production [PDF]

, 2003
Nicole J. Horwood, Tara Mahon, John McDaid, Jamie I. D. Campbell, Hiroyuki Mano, Fionula M. Brennan, David Webster, Brian M. J. Foxwell   +7 more
openalex   +1 more source

Toll-like receptor 2 (TLR2) and TLR4 signaling in the innate response against bacterial components [PDF]

, 2008
Toll-like receptors (TLRs) are transmembrane proteins involved in the recognition of specific microbial structures and thus the activation of signaling cascades of innate immunity.
Liljeroos, Mari
core  

Editorial: New Insights on Bruton’s Tyrosine Kinase Inhibitors [PDF]

Frontiers in Immunology, 2021
Rula Zain, Rula Zain, Jennifer R. Brown, C. I. Edvard Smith   +3 more
openaire   +4 more sources