Rilzabrutinib for the Treatment of Immune Thrombocytopenia
ABSTRACT Advancements in the understanding of ITP pathogenesis have led to significant improvements in disease management through the use of both traditional immunosuppressive strategies and novel targeted therapies. However, a subset of patients remains refractory to treatment or achieves only transient benefits, underscoring the need for alternative ...
Caterina Labanca+12 more
wiley +1 more source
G Protein βγ Subunits Act on the Catalytic Domain to Stimulate Bruton's Agammaglobulinemia Tyrosine Kinase [PDF]
William E. Lowry, Xin‐Yun Huang
openalex +1 more source
Follicle on the Roof: Tertiary Lymphoid Structures in Central Nervous System Autoimmunity
ABSTRACT Leptomeningeal tertiary lymphoid structures (TLS) have emerged as a relatively common pathological feature of autoimmune disease, including multiple sclerosis (MS) and particularly in people with progressive and nonremitting MS. These ectopic lymphoid aggregates, observed in the leptomeninges adjacent to so‐called “Type 3” sub‐pial cortical ...
Michelle Zuo+2 more
wiley +1 more source
In recent years, there has been a focus on developing and discovering novel Bruton's tyrosine kinase (BTK) inhibitors, as they offer an effective treatment strategy for B-cell malignancies.
Mourad Aloui+10 more
doaj
Identification of mutations of Bruton's tyrosine kinase gene (BTK) in Brazilian patients with X-linked agammaglobulinemia [PDF]
Sergio Massayuki Tani+6 more
openalex +1 more source
Involvement of Bruton's tyrosine kinase in FcepsilonRI-dependent mast cell degranulation and cytokine production. [PDF]
We investigated the role of Bruton's tyrosine kinase (Btk) in FcepsilonRI-dependent activation of mouse mast cells, using xid and btk null mutant mice.
Alt, FW+16 more
core
Trajectories of allergic diseases in children: Destination unknown?
Abstract The trajectories of allergic diseases represent one of the most currently debated topics both when referred to childhood and likewise adulthood. Data from cohorts show their heterogeneity as well as the key role of genetic and environmental factors.
Birgit Kalb+13 more
wiley +1 more source
Bruton's Tyrosine Kinase Is Required For Lipopolysaccharide-induced Tumor Necrosis Factor α Production [PDF]
Nicole J. Horwood+7 more
openalex +1 more source
Toll-like receptor 2 (TLR2) and TLR4 signaling in the innate response against bacterial components [PDF]
Toll-like receptors (TLRs) are transmembrane proteins involved in the recognition of specific microbial structures and thus the activation of signaling cascades of innate immunity.
Liljeroos, Mari
core
Editorial: New Insights on Bruton’s Tyrosine Kinase Inhibitors [PDF]
Rula Zain+3 more
openaire +4 more sources