Results 211 to 220 of about 5,286 (232)

Signalling of Bruton's Tyrosine Kinase, Btk

Scandinavian Journal of Immunology, 1999
Bruton's tyrosine kinase, which is encoded by the BTK gene, is a cytoplasmic protein tyrosine kinase (PTK) crucial for B‐cell development and differentiation. It belongs to the Tec family of PTKs containing several domains that are characteristic of signalling molecules.
A J, Mohamed, B F, Nore, B, Christensson, C I, Smith   +3 more
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Bruton’s tyrosine kinase (Btk)—the critical tyrosine kinase in LPS signalling?

Immunology Letters, 2004
The discovery of the Toll-like receptors (TLRs) has revolutionised the field of innate immunity. One unresolved question regarding LPS signalling is whether there is a role for tyrosine kinases downstream of the LPS receptor. Studies in mice deficient in Bruton's tyrosine kinase have previously shown that they are defective in their responses to LPS ...
Caroline A, Jefferies, Luke A J, O'Neill
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Brutons Tyrosine Kinase as a New Therapeutic Target

Anti-Cancer Agents in Medicinal Chemistry, 2007
Targeting Brutons tyrosine kinase (BTK) with a small molecule inhibitor may be useful in treatment of BTK-expressing malignancies because of the anti-apoptotic function of BTK in cancer cells. Furthermore, BTK inhibitors also exhibit anti-thrombotic properties that may be desirable in the context of the increased risk of thromboembolic ...
Fatih M, Uckun, Heather E, Tibbles, Alexei O, Vassilev   +2 more
openaire   +2 more sources

Cardiovascular Toxicities of Bruton’s Tyrosine Kinase Inhibitors

Current Treatment Options in Oncology, 2020
There has been a significant shift in the management of B cell malignancies over the past decade. Initial strategies involving the use of systemic chemotherapies have been gradually replaced by more targeted therapies to improve survival and overall tolerability.
Ricardo, Pineda-Gayoso, Mohammed, Alomar, Dae Hyun, Lee, Michael G, Fradley   +3 more
openaire   +2 more sources

Role of Bruton’s tyrosine kinase in macrophage apoptosis

Apoptosis, 2010
Macrophages and polymorphonuclear cells (PMNs) rapidly respond to microbial and immune inflammatory stimuli and die during these responses. We have shown earlier that many macrophage and PMN functions are compromised in x-linked immunodeficient (Xid) mice with functional deficiency in Bruton's tyrosine kinase (Btk).
Anupriya, Khare, Bharathi, Viswanathan, Rupali, Gund, Nidhi, Jain, Balachandran, Ravindran, Anna, George, Satyajit, Rath, Vineeta, Bal   +7 more
openaire   +2 more sources

Phosphorylation of Bruton’s tyrosine kinase by c-Abl

Biochemical and Biophysical Research Communications, 2002
Bruton's tyrosine kinase (Btk) is necessary for B-lymphocyte development. Mutation in the gene coding for Btk causes X-linked agammaglobulinemia (XLA) in humans. Similar to Btk, c-Abl is a tyrosine kinase shuttling between the cytoplasm and the nucleus where it is involved in different functions depending on the localization. In this report we describe
Carl Magnus, Bäckesjö, Leonardo, Vargas, Giulio, Superti-Furga, C I, Smith   +3 more
openaire   +2 more sources

Bruton Tyrosine Kinase Degraders

American Journal of Clinical Oncology
Bruton tyrosine kinase (BTK) is a key enzyme involved in B-cell development and signaling, making it a crucial target in the treatment of B-cell malignancies, such as chronic lymphocytic leukemia and non-Hodgkin lymphoma. While BTK inhibitors (BTKi), such as ibrutinib, have been effective, resistance—both intrinsic and acquired—poses a significant ...
Giorgi, Sabakhtarishvili, Mouza, Alshebli, Omer, Bajwa, Imad A, Tabbara   +3 more
openaire   +2 more sources

Bruton's Tyrosine Kinase (Btk)

2012
Bruton's tyrosine kinase (Btk) is a non-receptor tyrosine kinase belonging to the Tec family of kinases. Btk is critical for B-cell development, differentiation and signalling through the B-cell antigen receptor (BCR) as is evident by its genetic association to a human primary immunodeficiency disease known as X-linked Agammaglobulinemia (XLA).
MARK E. SCHNUTE, ADRIAN HUANG, EDDINE SAIAH   +2 more
openaire   +1 more source

Production of Monoclonal Antibodies to Bruton's Tyrosine Kinase

Hybridoma, 1995
Bruton's X-linked agammaglobulinemia is caused by mutations in a cytoplasmic protein tyrosine kinase termed Bruton's tyrosine kinase (BTK). The protein is expressed in all members of the B cell lineage and is critical for B cell development. The protein consists of several modules, including a pleckstrin homology domain and the Src homology domains SH1,
D M, Stewart, C C, Kurman, D L, Nelson
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Resistance to Bruton Tyrosine Kinase Inhibitors

Hematology/Oncology Clinics of North America
Targeting Bruton tyrosine kinase (BTK) has revolutionized the therapy for chronic lymphocytic leukemia. As patients remain on therapy, however, resistance develops progressively over time. The most common mechanism of resistance to covalent BTK inhibitors is mutation of the C481 target residue to serine, abrogating covalent binding.
openaire   +2 more sources