Results 81 to 90 of about 178,517 (322)

Myeloid-Derived Suppressor Cells Express Bruton's Tyrosine Kinase and Can Be Depleted in Tumor-Bearing Hosts by Ibrutinib Treatment.

Cancer Research, 2016
Myeloid-derived suppressor cells (MDSC) are a heterogeneous group of immature myeloid cells that expand in tumor-bearing hosts in response to soluble factors produced by tumor and stromal cells.
Andrew Stiff, P. Trikha, R. Wesolowski, K. Kendra, Vincent Hsu, Sarvani Uppati, Elizabeth L. McMichael, Megan C. Duggan, Amanda R. Campbell, Karen A. Keller, I. Landi, Y. Zhong, J. Dubovsky, J. H. Howard, Lianbo Yu, Bonnie K. Harrington, M. Old, S. Reiff, T. Mace, S. Tridandapani, N. Muthusamy, M. Caligiuri, J. Byrd, W. Carson   +23 more
semanticscholar   +1 more source

Micro RNA 145 targets the insulin receptor substrate-1 and inhibits the growth of colon cancer cells [PDF]

, 2007
The insulin receptor substrate-1 (IRS-1), a docking protein for both the type 1 insulin-like growth factor receptor (IGF-IR) and the insulin receptor, is known to send a mitogenic, anti-apoptotic, and anti-differentiation signal. Several micro RNAs (miRs)
Baserga, Renato, deAngelis, Tiziana, Linsley, Peter, Prisco, Marco, Sepp-Lorenzino, Laura, Shi, Bin   +5 more
core   +2 more sources

The power of microRNA regulation—insights into immunity and metabolism

FEBS Letters, EarlyView.
MicroRNAs are emerging as crucial regulators at the intersection of metabolism and immunity. This review examines how miRNAs coordinate glucose and lipid metabolism while simultaneously modulating T‐cell development and immune responses. Moreover, it highlights how cutting‐edge artificial intelligence applications can identify miRNA biomarkers ...
Stefania Oliveto, Nicola Manfrini, Stefano Biffo   +2 more
wiley   +1 more source

Conformational snapshots of Tec kinases during signaling [PDF]

, 2009
The control of cellular signaling cascades is of utmost importance in regulating the immune response. Exquisitely precise protein-protein interactions and chemical modification of substrates by enzymatic catalysis are the fundamental components of the ...
Afar, Andreotti, Andreotti, August, Baraldi, Berg, Berg, Bogin, Bose, Bradshaw, Brazin, Brazin, Breheny, Brown, Brown, Bubeck Wardenburg, Bunnell, Bunnell, Chan, Ching, Christoph Grathwohl, Colgan, Cory, Cowan-Jacob, Cozier, Deindl, DeLano, Engen, Felices, Feng, Ferguson, Filippakopoulos, Fukuda, Garcon, Goldsmith, Gomez-Rodriguez, Gothel, Haire, Hansson, Hansson, Hao, Hashimoto, Hawkins, Heyeck, Heyeck, Huang, Huang, Hubbard, Hubbard, Huse, Hyvonen, Johnson, Joseph, Joseph, Joseph, Kaneko, Kashiwakura, Kato, Kojima, Kurosaki, Laederach, Laederach, Lamers, Latour, Lee, Lee, Lemmon, Lemmon, Lemmon, Levinson, Li, Li, Li, Lin, Lin, Liu, Mallis, Manning, Mano, Mao, Marengere, Marquez, Matsushita, Mihara, Mikkola, Mohamed, Morrogh, Murayama, Nagar, Nore, Ogawa, Park, Parsons, Pawson, Perez-Villar, Pletneva, Prade, Pursglove, Qi, Rawlings, Remenyi, Salim, Scharenberg, Schlessinger, Schmidt, Schwartzberg, Severin, Shan, Shoelson, Sicheri, Siliciano, Smith, Sondhi, Su, Sun, Takata, Tamagnone, Thomas, Tomlinson, Tzeng, Ubersax, Varnai, Veillette, Vetrie, Vihinen, Wang, Wilcox, Williams, Wong, Yamadori, Yamaguchi, Yang, Yang, Yu   +133 more
core   +3 more sources

The cytoskeletal control of B cell receptor and integrin signaling in normal B cells and chronic lymphocytic leukemia

FEBS Letters, EarlyView.
In lymphoid organs, antigen recognition and B cell receptor signaling rely on integrins and the cytoskeleton. Integrins act as mechanoreceptors, couple B cell receptor activation to cytoskeletal remodeling, and support immune synapse formation as well as antigen extraction.
Abhishek Pethe, Tanja Nicole Hartmann
wiley   +1 more source

B cell mechanobiology in health and disease: emerging techniques and insights into therapeutic responses

FEBS Letters, EarlyView.
B cells sense external mechanical forces and convert them into biochemical signals through mechanotransduction. Understanding how malignant B cells respond to physical stimuli represents a groundbreaking area of research. This review examines the key mechano‐related molecules and pathways in B lymphocytes, highlights the most relevant techniques to ...
Marta Sampietro, Marco Cellani, Cristina Scielzo   +2 more
wiley   +1 more source

Single‐cell insights into the role of T cells in B‐cell malignancies

FEBS Letters, EarlyView.
Single‐cell technologies have transformed our understanding of T cell–tumor cell interactions in B‐cell malignancies, revealing new T‐cell subsets, functional states, and immune evasion mechanisms. This Review synthesizes these findings, highlighting the roles of T cells in pathogenesis, progression, and therapy response, and underscoring their ...
Laura Llaó‐Cid
wiley   +1 more source

Immune response to COVID‐19 vaccination in patients with Waldenström macroglobulinaemia who pause their BTKi therapy

eJHaem, 2023
Patients with Waldenström macroglobulinaemia (WM) are at increased risk of severe COVID‐19 infection and have poor immune responses to COVID‐19 vaccination. This study assessed whether a closely monitored pause in Bruton's Tyrosine Kinase inhibitor (BTKi)
Katherine Rankin, Priyanka Hastak, Alexander Wong, Sarah C. Sasson, Brendan Beaton, Avani Yeola, Andrew Warden, Stuart Turville, Anthony D. Kelleher, Fabienne Brilot, Judith Trotman   +10 more
doaj   +1 more source

A case of chronic lymphocytic leukemia with unmutated variable region of the immunoglobulin heavy chain gene with markedly high lactate dehydrogenase responding to ibrutinib

Journal of Applied Hematology, 2021
Chronic lymphocytic leukemia (CLL) is the most common leukemia in adults. Several prognostic factors exist that help stratify patients into different risk categories.
Musa Alzahrani
doaj   +1 more source

Ofatumumab and high-dose methylprednisolone for the treatment of patients with relapsed or refractory chronic lymphocytic leukemia. [PDF]

, 2014
Ofatumumab is a humanized anti-CD20 monoclonal antibody that has been approved by the FDA for the treatment of patients with chronic lymphocytic leukemia. We conducted a phase II single-arm study at a single center.
Almahasnah, E, Carvajal, T, Castro, JE, Chang, J, Choi, MY, James, DF, Kipps, TJ   +6 more
core   +3 more sources