Results 51 to 60 of about 66,193 (232)

Identification and functional characterization of a novel gene conferring root rot resistance in Panax Notoginseng

BMC Plant Biology
Background Panax notoginseng is highly susceptible to root rot during cultivation, a disease that severely reduces yield and compromises quality, thereby constraining sustainable industry development.
Manqiao Li, Zihan Yang, Kuixiu Li, Xuyan Liu, Yueyue Zhu, Zihan Yang, Fugang Wei, Shengchao Yang, Guanze Liu   +8 more
doaj   +1 more source

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

Next-Generation Sequencing from Bulked-Segregant Analysis Accelerates the Simultaneous Identification of Two Qualitative Genes in Soybean

Frontiers in Plant Science, 2017
Next-generation sequencing (NGS)-based bulked-segregant analysis (BSA) approaches have been proven successful for rapidly mapping genes in plant species.
Jian Song, Zhen Li, Zhangxiong Liu, Yong Guo, Li-Juan Qiu   +4 more
doaj   +1 more source

Long‐term hippocampal alterations and cognitive impairment in a murine model of surgical sepsis

FEBS Open Bio, EarlyView.
Using a mouse model of surgical sepsis, we tested long‐term memory and analyzed the transcriptome of single cells isolated from the hippocampus. Survivor mice showed worse memory, loss of certain brain cell subpopulations, and abnormal immune cell activity—suggesting that post‐sepsis brain alterations may be linked to cognitive deficits.
Dong Seong Cho, Rebecca Schmitt, Aneesha Dasgupta, Alexandra Ducharme, Jason Doles   +4 more
wiley   +1 more source

Loss of AMBRA1 activates MAPK and angiogenesis signaling pathways in melanoma cells

FEBS Open Bio, EarlyView.
Loss of AMBRA1 in melanoma cells activates multiple oncogenic pathways associated with tumor progression. Transcriptomic and protein network analyses revealed that AMBRA1 depletion enhances MAPK/ERK signaling, angiogenesis, TGF‐β/EMT signaling, and Wnt/axon guidance pathways.
Milad Ibrahim, Marco Corazzari, Iman Osman, Jane Armstrong, Noel Carter   +4 more
wiley   +1 more source

Research Note: Combined analysis of BSA-seq based mapping and RNA-seq reveals candidate genes associated with sub-Columbian plumage in H line chickens

Poultry Science, 2023
: Columbian coloration patterns in plumage are widespread phenomena in several standard breeds of poultry, such as the Columbian Plymouth Rock chicken. H line chicken plumage is generally a pure white except in the hackle, wing, and tail plumage, which ...
Ruiting Li, Xinlei Wang, Yanxing Wang, Danli liu, Yushi Zhang, Yang Liu, Xinran Niu, Ruili Han, Hong Li, Ruirui Jiang, Guirong Sun, Guoxi Li, Yadong Tian, Xiaojun Liu, Xiangtao Kang, Zhuanjian Li   +15 more
doaj   +1 more source

Tuning Mechanoreceptor Signaling Enhances the Adjuvant Effect of Biomaterial Vaccines

Advanced Functional Materials, EarlyView.
Matrix stiffness serves as an independent immunological signal in biomaterial vaccines. Stiffer microporous hydrogel vaccines enhance dendritic cell maturation and migration to draining lymph nodes, promote T follicular helper cell expansion through Yap/Taz signaling, and increase antigen‐specific antibody production.
Lily Shang, Daniel P. Mayer, Prabhat K. Purbey, Yingzi Liu, Kindra Kelly‐Scumpia, Clara Kang, Natalie Tsubamoto, Dhriti Bolangadi, Iqra Arshad, Charisse Ng, Maksim V. Plikus, Dino Di Carlo, Jason S. Weinstein, Philip O. Scumpia   +13 more
wiley   +1 more source

Flash Assembloids: A Rapid Biofabrication of a Platform for Modeling Early Glioblastoma Invasion at the Glioblastoma–Brain Organoid Interfaces

Advanced Healthcare Materials, EarlyView.
This study presents a bioengineered assembloid (ASM) system combining glioblastoma (GBM) cells in oxidized alginate (OA) microgels with dorsal organoids (DOs). This model simulates brain tumor‐host interactions, revealing enhanced GBM invasion, altered gene expression, and aggressive infiltration patterns, demonstrating ASM as a valuable platform for ...
Chao Liang, Henry Robert Howard, Shihui Chen, Won‐Young Choi, Summer Cao, Arthur Chien, Kevin Zou, Michael Kassiou, Fabien Delerue, Ho Sang Jung, Yeonju Park, Young Mee Jung, Yong‐Dae Kwon, Karrie M. Kiang, Gilberto Ka‐Kit Leung, Ryohichi Sugimura, Ann‐Na Cho, Sang Jin Lee   +17 more
wiley   +1 more source

Identification of candidate genes for watermelon (Citrullus lanatus) seed weight trait by BSA-seq

Molecular Breeding
Watermelon seed size is a key agricultural trait with important economic significance. Seed weight is one of the standards for measuring seed size, yet its genetic mechanisms and variation remain unclear. In this study, the F2 genetic population was constructed using Zhengzhou wild (big seeds) and [(microparticles × 102B4) × 102B4] (small seeds) as ...
Rui Sun, Meng-Ling Zheng, Hai-Nan Liu, Long Zhao, Zhong-Hou Zhu, Xue-Jie Zhu, Da-Long Guo   +6 more
openaire   +2 more sources

Mining candidate genes of single fruit mass in peach by BSA-seq and RNA-seq analysis [PDF]

Guoshu xuebao
[Objective] Single fruit mass is a critical target in crop production and the domestication of horticultural species. This study aimed to identify candidate genes influencing peach (Prunus persica L.) single fruit mass, providing valuable insights for ...
BIE Hangling, DU Jiayi, CHEN Changwen, FANG Weichao, WANG Lirong, CAO Ke   +5 more
doaj   +1 more source