Results 61 to 70 of about 66,193 (232)

Therapeutic Extracellular Vesicles from Synovial Fibroblast‐Primed MSCs for Osteoarthritis Treatment

Advanced Healthcare Materials, EarlyView.
EVs derived from the microenvironment of SFs transferred MSCs (miSF‐MSC‐EVs) enhanced the expression of miRNAs that regulate cell migration, cell adhesion, and the TGF‐β signaling pathway, demonstrating superior anti‐inflammatory and cartilage regeneration effects compared to conventional MSC‐EVs.
Seo Jeong Kim, Ji Seob Kim, Min Hee Moon, Jae‐Hyeok Jang, In Sun Hwang, Byung‐Hyun Cha   +5 more
wiley   +1 more source

HMGR regulates floral fragrance through terpene synthesis pathway in Paeonia suffruticosa

Industrial Crops and Products
Tree peony is an aromatic plant that is rich in terpenoids. However, there are fewer studies on terpene synthesis related genes. In this study, the molecular mechanism of terpene synthesis in Paeonia suffruticosa was investigated by bulked segregant ...
Tongfei Niu, Linfeng Chen, Erqiang Wang, Dongfeng Wei, Yuying Li, Ruiya Li, Duoduo Wang, Lili Guo, Xiaogai Hou   +8 more
doaj   +1 more source

A Novel Perfused Full‐Thickness Human Skin Microphysiological System for Modeling Injury, Regeneration, Tumor Pathophysiology, and Therapeutics Development

Advanced Healthcare Materials, EarlyView.
What if human skin could remain fully alive and functional outside the body for weeks? A New Alternative Method (NAM) based on a vascularized full‐thickness skin microphysiological system achieves precisely this, preserving native vasculature, resident immunity, and metabolic activity for up to three weeks, while faithfully recapitulating radiation ...
Yusuf Surucu, Hamid Malekzadeh, Alexa Rivera Del Rio Hernandez, Naresh Mahajan, Ethan Banks, Dayyan Ur Rahman, José A. Arellano, Katherine S. Yang, Alexey Altman, G.V. Naveen Kumar, Matthew L. Steinhauser, Jeffrey A. Gusenoff, J. Peter Rubin, Asim Ejaz   +13 more
wiley   +1 more source

Rapid Mining of Candidate Genes for the Branchless Phenotype in Watermelon by Bulked Segregant Analysis Using Whole-genome Resequencing

Journal of the American Society for Horticultural Science
Lateral branching is an important agronomic trait in horticulture plants. The aim of this project was to reveal the genetic mechanism, map the gene localization, and predict candidate genes of watermelon lateral branching.
Kaili Ren, Yongquan Su, Taoxia Tang, Weiping Kong, Yonggang Yang, Xiaoqin Zhao, Hong Cheng   +6 more
doaj   +1 more source

A 3D‐Printed Vascular‐Like Perfusion Tumor‐on‐a‐Chip Recapitulates High‐Grade Breast Cancer With in Vivo‐Relevant Drug Resistance

Advanced Healthcare Materials, EarlyView.
A high‐resolution 3D‐printed tumor‐on‐a‐chip platform sustains breast cancer tissues at in vivo–like cell densities through vascular‐like perfusion. This engineered system recapitulates grade‐dependent molecular features and exhibits drug‐resistance profiles that uniquely align with clinically relevant Cmax values.
Geonhui Lee, Bingjie Sun, Nicholas X. Fang, Chunguang Xia   +3 more
wiley   +1 more source

Mapping Cucumber Vein Yellowing Virus Resistance in Cucumber (Cucumis sativus L.) by Using BSA-seq Analysis [PDF]

Frontiers in Plant Science, 2019
Cucumber vein yellowing virus (CVYV) causes severe yield losses in cucurbit crops across Mediterranean countries. The control of this virus is based on cultural practices to prevent the presence of its vector (Bemisia tabaci) and breeding for natural resistance, which requires the identification of the loci involved and the development of molecular ...
Marta Pujol, Marta Pujol, Konstantinos G. Alexiou, Konstantinos G. Alexiou, Anne-Sophie Fontaine, Patricia Mayor, Manuel Miras, Torben Jahrmann, Jordi Garcia-Mas, Jordi Garcia-Mas, Miguel A. Aranda   +10 more
openaire   +6 more sources

The Construction of a Mutant Library of Linseed and the Molecular Mechanism of High Oleic Acid Mutants from a Multi-Omics Perspective

Plants
Flax (Linum usitatissimum L.) is a globally important oilseed crop, valued for its edible and industrial uses. Flax seeds are rich in unsaturated fatty acids.
Caiyue Liu, Xinsen Yang, Qiaoling Tang, Xiuxia Cao, Aiping Qian, Zhiwei Yang, Limin Wang, Jianping Zhang, Xinwu Pei, Lu Gan   +9 more
doaj   +1 more source

Engineered Microvascular Model of the Blood–Brain–Tumor Barrier Reveals Endothelial Remodeling in Diffuse Midline Glioma

Advanced Healthcare Materials, EarlyView.
We developed a patient‐derived, functional microfluidic model of the diffuse midline glioma (DMG) blood–brain–tumor barrier (BBTB) comprised of endothelial cells, astrocytes, pericytes, and tumor cells. The system forms perfusable microvasculature, reveals the BBTB retains vascular integrity, identifies DMG‐specific transcriptomic changes distinct from
Kimberly R. Bennett, Yann S. Vanrobaeys, Tessy Teboh, Zakiya Smith, Anderson Scott, Cynthia Hajal, Paula T. Hammond, Joelle P. Straehla   +7 more
wiley   +1 more source

Fine mapping of the gene controlling the weeping trait of Prunus persica and its uses for MAS in progenies

BMC Plant Biology, 2022
Background Fruit tree yield and fruit quality are affected by the tree’s growth type, and branching angle is an important agronomic trait of fruit trees, which largely determines the crown structure.
Luwei Wang, Lei Pan, Liang Niu, Guochao Cui, Bin Wei, Wenfang Zeng, Zhiqiang Wang, Zhenhua Lu   +7 more
doaj   +1 more source

The Dark Side of the pollen: BSA-seq identified genomic regions linked to male sterility in globe artichoke. [PDF]

BMC Plant Biol
AbstractGlobe artichoke (Cynara cardunculus var. scolymus; 2n = 2x = 34) is a food crop consumed for its immature flower heads. Traditionally, globe artichoke varietal types are vegetatively propagated. However, seed propagation makes it possible to treat the crop as annual, increasing field uniformity and reducing farmers costs, as well as pathogens ...
Martina M, Zayas A, Portis E, Di Nardo G, Polli MF, Comino C, Gilardi G, Martin E, Acquadro A.   +8 more
europepmc   +6 more sources