Results 1 to 10 of about 69,832 (232)

Splice-correcting oligonucleotides restore BTK function in X-linked agammaglobulinemia model [PDF]

, 2014
X-linked agammaglobulinemia (XLA) is an inherited immunodeficiency that results from mutations within the gene encoding Bruton’s tyrosine kinase (BTK). Many XLA-associated mutations affect splicing of BTK pre-mRNA and severely impair B cell development ...
Behlke, Mark A, Berglöf, Anna, Bestas, Burcu, Blomberg, K Emelie M, El Andaloussi, Samir, Gait, Michael J, Gustafsson, Manuela O, Guterstam, Peter, Kharazi, Shabnam, Lundin, Karin E, Mohammad, Dara K, Moreno, Pedro M D, Månsson, Robert, Nordin, Joel Z, Piątosa, Barbara, Roberts, Thomas C, Saleh, Amer F, Smith, C I Edvard, Sutlu, Tolga, Wengel, Jesper, Wood, Matthew J A   +20 more
core   +3 more sources

Combining BTK inhibitors with BCL2 inhibitors for treating chronic lymphocytic leukemia and mantle cell lymphoma [PDF]

Biomarker Research, 2022
The advent of BTK inhibitors has changed the treatment of patients with chronic lymphocytic leukemia (CLL) and mantle cell lymphoma (MCL). The first-in-class BTK inhibitor ibrutinib has shown remarkable therapeutic effects and manageable toxicities in ...
Jing Zhang, Xueying Lu, Jianyong Li, Yi Miao   +3 more
doaj   +2 more sources

BTK Inhibition in Hematology: From CLL/SLL to Emerging Applications Across B-Cell and Immune Disorders [PDF]

Biomolecules
BTK (Bruton’s tyrosine kinase) has become a key therapeutic target across several hematologic diseases, beginning with its original use in CLL/SLL.
Andrea Duminuco, Paola De Luca, Gaia Stanzione, Laura Anastasia Caruso, Giulio Lavenia, Salvatore Scarso, Bruno Garibaldi, Fanny Erika Palumbo, Calogero Vetro, Giuseppe Alberto Palumbo   +9 more
doaj   +2 more sources

Inhibition of bruton’s tyrosine kinase directly alleviates pathogenic CD4+ T cell response via PPAR-γ signaling in autoimmune uveitis [PDF]

Journal of Neuroinflammation
Background Bruton’s tyrosine kinase (BTK), a key regulator of immune responses, has been extensively studied in B cells and innate immunocytes. Small-molecule BTK inhibitors (BTKi) have shown remarkable efficacy in multiple preclinical and clinical ...
Zhiqiang Xiao, Zhuang Li, Wenjie Zhu, Guanyu Chen, Xiaoshuang Luo, Zhiqing Mai, Minzhen Wang, Haixiang Huang, Zuoyi Li, Yuxun Shi, Yanyan Xie, Hao Wu, Xiaoqing Chen, Dan Liang   +13 more
doaj   +2 more sources

SY-1530, a highly selective BTK inhibitor, effectively treats B-cell malignancies by blocking B-cell activation

Cancer Biology & Medicine, 2022
Objective: B-cell antigen receptor (BCR) signaling is required to maintain the physiological functions of normal B cells and plays an important pathogenic role in B-cell malignancies. Bruton tyrosine kinase (BTK), a critical mediator of BCR signaling, is
Liao Wang, Yinghui Sun, Xijie Liu, Hongjuan Li, Chang Lu, Ronghui Yang, Chuanzhen Yang, Binghui Li   +7 more
doaj   +1 more source

Pirtobrutinib in Chronic Lymphocytic Leukemia: Navigating Resistance and the Personalisation of BTK-Targeted Therapy. [PDF]

Cancers (Basel)
Molica S, Allsup D.
europepmc   +3 more sources

Novel antiplatelet strategies targeting GPVI, CLEC-2 and tyrosine kinases

Platelets, 2021
Antiplatelet medications comprise the cornerstone of treatment for diseases that involve arterial thrombosis, including acute coronary syndromes (ACS), stroke and peripheral arterial disease.
Maan H. Harbi, Christopher W. Smith, Phillip L. R. Nicolson, Steve P. Watson, Mark R. Thomas   +4 more
doaj   +1 more source

Structure-based virtual screening and biological evaluation of novel small-molecule BTK inhibitors

Journal of Enzyme Inhibition and Medicinal Chemistry, 2022
Bruton tyrosine kinase (BTK) is linked to multiple signalling pathways that regulate cellular survival, activation, and proliferation. A covalent BTK inhibitor has shown favourable outcomes for treating B cell malignant leukaemia.
Tony Eight Lin, Li-Chin Sung, Min-Wu Chao, Min Li, Jia-Huei Zheng, Tzu-Ying Sung, Jui-Hua Hsieh, Chia-Ron Yang, Hsueh-Yun Lee, Er-Chieh Cho, Kai-Cheng Hsu   +10 more
doaj   +1 more source

Megjegyzések a lokális Craig interpolációhoz

Elpis, 2022

Zalán Molnár, Övge Öztürk
doaj   +1 more source

Egyetemi hallgatók környezettudatossága a materializmus, az élettel való elégedettség, a politikai, illetve a pandémiával kapcsolatos nézeteik függvényében

Metszetek, 2022
Az elmúlt évtizedekben egyre nagyobb figyelmet kap a környezeti problémák és az ezzel ös - szefüggő társadalmi jelenségek vizsgálata. Az egyetemi hallgatók környezettudatosságának és környezettudatosságukat befolyásoló tényezőknek a megismerése ...
Ferenc Mónus, Tamás Béres, Flórián Sipos   +2 more
doaj   +1 more source