Results 111 to 120 of about 80,266 (330)

BTK Inhibition Attenuates FcεR1-Dependent Bronchoconstriction in Human Precision Cut Lung Slices [PDF]

, 2021
Cynthia Koziol‐White, J. Jude, N. Karmacharya, R. Bauer, M. Wilson, D. Choy, Reynold A. Panettieri   +6 more
openalex   +1 more source

Btk Inhibitors: A Medicinal Chemistry and Drug Delivery Perspective

International Journal of Molecular Sciences, 2021
In the past few years, Bruton’s tyrosine Kinase (Btk) has emerged as new target in medicinal chemistry. Since approval of ibrutinib in 2013 for treatment of different hematological cancers (as leukemias and lymphomas), two other irreversible Btk ...
C. Brullo, Carla Villa, B. Tasso, E. Russo, A. Spallarossa   +4 more
semanticscholar   +1 more source

Fat Mass and Obesity‐Associated Protein Contributes to Tumorigenesis and Drug Resistance of Diffuse Large B‐Cell Lymphoma by Suppressing N6‐Methyladenosine Methylation of Myc

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Ibrutinib resistance remains a major obstacle in the treatment of diffuse large B‐cell lymphoma (DLBCL). Fat mass and obesity‐associated protein (FTO) has been implicated in drug resistance through its regulation of N6‐methyladenosine (m6A) modifications; however, whether FTO mediates ibrutinib resistance in DLBCL remains unclear.
Ting‐Ting Lu, Jin‐Hao Chen, Yan‐Fang Wang, Xiao Wu, Hui‐Yun Ni, Qiu‐Rong Zhang   +5 more
wiley   +1 more source

Cirmtuzumab inhibits Wnt5a-induced Rac1 activation in chronic lymphocytic leukemia treated with ibrutinib. [PDF]

, 2016
Signaling via the B cell receptor (BCR) plays an important role in the pathogenesis and progression of chronic lymphocytic leukemia (CLL). This is underscored by the clinical effectiveness of ibrutinib, an inhibitor of Bruton's tyrosine kinase (BTK) that
Chen, L, Chen, Y, Choi, MY, Cui, B, Kipps, TJ, Rassenti, LZ, Widhopf Ii, GF, Wu, Christina, Yu, J, Zhang, L   +9 more
core   +1 more source

Placebo-Controlled Trial of an Oral BTK Inhibitor in Multiple Sclerosis.

New England Journal of Medicine, 2019
BACKGROUND Bruton's tyrosine kinase (BTK) regulates the functions of B cells and myeloid cells that are implicated in the pathogenesis of multiple sclerosis.
X. Montalban, D. Arnold, Martin S. Weber, I. Staikov, Karolina Piasecka-Stryczynska, J. Willmer, E. Martin, F. Dangond, S. Syed, J. Wolinsky   +9 more
semanticscholar   +1 more source

Nano Delivery Strategy Opens Effective Avenues for the Treatment of Colorectal Cancer

Medicine Bulletin, EarlyView.
ABSTRACT Colorectal cancer (CRC) presents significant therapeutic challenges because of chemoresistance, systemic toxicity, and the complexity of the tumor microenvironment (TME). Nanodrug delivery systems (NDDS) have emerged as versatile platforms capable of overcoming these limitations by enhancing tumor accumulation, improving pharmacokinetics, and ...
Qiurong Wei, Yunli Xu, Tianjiao Zhang, Shuyu Xu, Haonan Wang, Yuan Wang, Xinxin Xie, Xiaolong Liang   +7 more
wiley   +1 more source

Irreversible inhibition of BTK kinase by a novel highly selective inhibitor CHMFL-BTK-11 suppresses inflammatory response in rheumatoid arthritis model

Scientific Reports, 2017
BTK plays a critical role in the B cell receptor mediated inflammatory signaling in the rheumatoid arthritis (RA). Through a rational design approach we discovered a highly selective and potent BTK kinase inhibitor (CHMFL-BTK-11) which exerted its ...
Hong Wu, Qiong Huang, Ziping Qi, Yongfei Chen, Aoli Wang, Cheng Chen, Qianmao Liang, Jinghua Wang, Wensheng Chen, Jin Dong, Kailin Yu, Chen Hu, Wenchao Wang, Xiaochuan Liu, Yuanxin Deng, Li Wang, Beilei Wang, Xiaoxiang Li, Nathanael S. Gray, Jing Liu, Wei Wei, Qingsong Liu   +21 more
doaj   +1 more source

The role of critical current on point contact Andreev Reflection spectrum between a normal metal and a superconductor

, 2003
The point contact spectrum between a normal metal and a superconductor often shows unexpected sharp dips in the conductance at voltage values larger than the superconducting energy gap.
Mukhopadhyay, S., Raychaudhuri, P., Sheet, G.   +2 more
core   +1 more source

Point Contact Spectroscopy of Superconducting Gap Anisotropy in Nickel Borocarbide Compound LuNi2B2C [PDF]

, 2004
Point contacts are used to investigate the anisotropy of the superconducting energy gap in LuNi2B2C in the ab plane and along the c axis. It is shown that the experimental curves should be described assuming that the superconducting gap is non-uniformly ...
A. A. Abrikosov, A. A. Abrikosov, A. V. Zaitsev, A. V. Zaitsev, D. G. Naugle, D. Kahaner, I. K. Yanson, K-H. Muller, K. D. D. Rathnayaka, L. V. Tyutrina, N. L. Bobrov, P. N. Chubov, S. I. Beloborod’ko, S. I. Beloborod’ko, Y. De Wilde   +14 more
core   +2 more sources

Inter‐Individual Differences in T1, T2, and Proton Density Using Quantitative Synthetic Imaging for 1H‐MRS Quantification

Magnetic Resonance in Medicine, EarlyView.
ABSTRACT Purpose Metabolite concentrations can be determined from proton magnetic resonance spectroscopy (1H‐MRS) data using water as an internal reference. This calculation requires tissue‐specific water T1 and T2 relaxation constants and proton density (PD).
Samantha A. Leech, Sarah L. Manske, Paul G. Mullins, Tiffany K. Bell, Ashley D. Harris   +4 more
wiley   +1 more source