Results 131 to 140 of about 78,184 (307)

Possible two-gap superconductivity in NdFeAs(O,F) probed by point-contact Andreev-reflection spectroscopy [PDF]

, 2008
Systematic studies of the NdFeAsOF superconducting energy gap via the point-contact Andreev-reflection (PCAR) spectroscopy are presented. The PCAR conductance spectra show at low temperatures a pair of gap-like peaks at about 4 - 7 mV indicating the ...
Bud'ko, S., Canfield, P. C., Pribulova, Z., Samuely, P., Szabo, P., Tillman, M. E.   +5 more
core   +1 more source

Basis for targeting BTK [PDF]

Science-Business eXchange, 2010
Genentech and Gilead researchers have discovered a potent and highly selective BTK inhibitor and have used it to tease out two BTK-mediated inflammatory pathways in arthritis. The findings add impetus for the development of BTK inhibitors in rheumatoid arthritis and other autoimmune diseases.
openaire   +1 more source

A multicentre analysis of efficacy, safety and molecular response correlates of fostamatinib in warm autoimmune haemolytic anaemia and Evans syndrome

British Journal of Haematology, EarlyView.
Fostamatinib had 46% durable response, with 73% steroid reduction, in this multicentre retrospective study of refractory wAIHA/ES. Hypertension, gastrointestinal (GI) distress and neutropenia occurred in 23%. Only one patient required drug discontinuation and one patient dose reduction.
Jorge N. Ruiz Lopez, Lipei Shao, Debbie Jiang, Lawrence S. Bailey, Thejaswi Bikkani, Aaron Boothby, Donald C. Moore, Irina Murakhovskaya, Caroline I. Piatek, Mauricio Pineda‐Roman, Ping Jin, Jacqueline N. Poston, Moritz Stolla, David F. Stroncek, Krystalyn E. Hudson, James B. Bussel, Sandhya R. Panch   +16 more
wiley   +1 more source

Covalent drug discovery: Progress against key targets, emerging strategies and lessons learnt

British Journal of Pharmacology, EarlyView.
Abstract Covalent drug discovery is currently experiencing a boom in industrial and academic interest. To date, at least 75 covalent drugs have received regulatory approval, targeting both traditional target classes and more challenging proteins for which other approaches failed. In many cases, unique aspects of covalent targeting are essential for the
Charles P. Brown, Alan Armstrong, David J. Mann   +2 more
wiley   +1 more source

Experimental evaluation of preprocessing algorithms for constraint satisfaction problems [PDF]

, 1992
This paper presents an experimental evaluation of two orthogonal schemes for preprocessing constraint satisfaction problems (CSPs). The first of these schemes involves a class of local consistency techniques that includes directional arc consistency ...
Dechter, Rina, Meiri, Itay
core  

Measurement of the spin polarization of the magnetic semiconductor EuS with zero-field and Zeeman-split Andreev reflection spectroscopy

, 2007
We report measurements of the spin polarization (\textbf{\textit{P}}) of the concentrated magnetic semiconductor EuS using both zero-field and Zeeman-split Andreev reflection spectroscopy (ARS) with EuS/Al planar junctions. The zero-field ARS spectra are
A. F. Andreev, A. F. Andreev, Cong Ren, J. G. Braden, J. S. Parker, J. Trbovic, P. Xiong, R. L. Kallaher, S. von Molnár, W. A. Thompson   +9 more
core   +1 more source

A Longitudinal Spaced‐Learning Approach to Support Faculty Calibration in Periodontal Diagnosis

Journal of Dental Education, EarlyView.
Clara S. Kim, Karen Matsumura‐Lem, Simon Hong, Tobias K. Boehm   +3 more
wiley   +1 more source

Cytology‐First Diagnostic Workflow for Melanoma of Unknown Primary With Molecular Profiling

Cytopathology, EarlyView.
Cytology‑first diagnostic workflow for melanoma of unknown primary. Fine‑needle aspiration of an enlarged lymph node enables rapid cytologic evaluation and immunocytochemical confirmation of melanocytic lineage (SOX10). This early cytologic diagnosis facilitates timely surgical excision and comprehensive genomic profiling, supporting integrated ...
Hong Yu, Mokhtar Abdelhammed, Xu Cao, Nisha S. Ramani   +3 more
wiley   +1 more source

Real‐World Selection of Venetoclax‐Obinutuzumab Versus BTK Inhibitor Therapy for Treatment‐Naïve Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma

European Journal of Haematology, EarlyView.
ABSTRACT Introduction Novel targeted agents have transformed the treatment of chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL), including continuous BTK inhibitor (BTKi) therapy and time‐limited regimens such as venetoclax‐obinutuzumab (Ven‐O) and ibrutinib‐venetoclax (I + V).
Rebecca Tidswell, Carolyn Owen, Mona Shafey, Sarah Perry, Nanette Cox‐Kennett, Russell Sterrett, Anthea Peters, Robert Puckrin   +7 more
wiley   +1 more source

Cost‐Effectiveness of Venetoclax‐Based Treatment in Treatment‐Naïve Fit Patients With CLL Without TP53 Aberrations

European Journal of Haematology, EarlyView.
ABSTRACT The GAIA‐CLL13 trial showed that venetoclax‐obinutuzumab (Ven‐O) based regimens, with or without ibrutinib, offer superior efficacy compared to chemoimmunotherapy (CIT) with regards to progression free survival (PFS) in fit, treatment‐naïve (TN) CLL patients. However, their higher costs warrant a cost‐effectiveness evaluation.
Lars Holger Ehlers, Mark‐David Levin, Marjolein van der Klift, Morten Berg Jensen, Hoa Thi Tuyet Tran, Arnon P. Kater, Carsten Utoft Niemann   +6 more
wiley   +1 more source