Results 141 to 150 of about 78,184 (307)

Suppressed Andreev Reflection at the Normal-Metal / Heavy-Fermion Superconductor CeCoIn$_5$ Interface

, 2005
Dynamic conductance spectra are taken from Au/CeCoIn$_5$ point contacts in the Sharvin limit along the (001) and (110) directions. Our conductance spectra, reproducibly obtained over wide ranges of temperature, constitute the cleanest data sets ever ...
Greene, Laura H., Park, Wan Kyu, Sarrao, John L., Thompson, Joe D.   +3 more
core   +1 more source

Acquired BTK mutations associated with resistance to noncovalent BTK inhibitors

Blood Advances, 2023
Jialei Qi, Sascha Endres, Deyan Yordanov Yosifov, Eugen Tausch, Rashmi Priyadharshini Dheenadayalan, Xiang Gao, Annika Müller, Christof Schneider, Daniel Mertens, Peter Gierschik, Martin Wist, Billy Michael Chelliah Jebaraj, Stephan Stilgenbauer   +12 more
openaire   +2 more sources

Acalabrutinib in Chronic Lymphocytic Leukemia: Pharmacology and Emerging Clinical Perspectives

European Journal of Haematology, EarlyView.
ABSTRACT Acalabrutinib, a second‐generation Bruton's tyrosine kinase inhibitor (BTKi), is characterized by enhanced specificity and selectivity for BTK with minimal off‐target effects, offering a significant evolution in the treatment of chronic lymphocytic leukemia (CLL). Its mechanism of action, a covalent binding to Cys481 within the BTK active site,
Gianluca Gaidano, Romano Danesi
wiley   +1 more source

Civil együttműködések a kistelepülési színtereken

Tér és Társadalom, 2007
A tanulmány egy, a rurális térségben, az egészség és életminőség fejlesztése terén tevékenykedő civil szervezetek körében készített (2006 novembere és 2007 áprilisa között végzett) felmérés eredményeit ismerteti.
Ragadics Tamás, Varga Ivett, Füzesi Zsuzsanna   +2 more
doaj   +1 more source

Management of Primary Refractory Diffuse Large B‐Cell Lymphoma in Patients Unsuitable for CAR T‐Cell Therapy

European Journal of Haematology, EarlyView.
ABSTRACT Primary refractory Diffuse Large B‐Cell Lymphoma is associated with poor outcomes and limited responsiveness to conventional salvage therapies. Although CAR T‐cell therapy represents the standard of care in this setting, a substantial proportion of patients cannot receive it despite meeting disease‐related criteria. In this review, “unsuitable”
Santino Caserta, Enrica Antonia Martino, Mamdouh Skafi, Maria Eugenia Alvaro, Antonella Bruzzese, Nicola Amodio, Eugenio Lucia, Virginia Olivito, Caterina Labanca, Francesco Mendicino, Ernesto Vigna, Fortunato Morabito, Massimo Gentile   +12 more
wiley   +1 more source

Distinct Roles for Bruton's Tyrosine Kinase in B Cell Immune Synapse Formation

Frontiers in Immunology, 2018
Bruton's tyrosine kinase (Btk) has a key role in the signaling pathways of receptors essential for the B lymphocyte response. Given its implication in B cell-related immunodeficiencies, leukemias/lymphomas and autoimmunity, Btk is studied intensely and ...
Sara Roman-Garcia, Sara V. Merino-Cortes, Sofia R. Gardeta, Marjolein J. W. de Bruijn, Rudi W. Hendriks, Yolanda R. Carrasco   +5 more
doaj   +1 more source

Andreev reflection spectroscopy of the heavy-fermion superconductor CeCoIn$_5$ along three different crystallographic orientations

, 2006
Andreev reflection spectroscopy has been performed on the heavy-fermion superconductor (HFS) CeCoIn$_5$ single crystals along three different crystallographic orientations, (001), (110), and (100), using Au tips as counter-electrodes. Dynamic conductance
Andreev, Aoki, Blonder, Covington, Deutscher, Deutscher, Goll, Izawa, Joe D. Thompson, John L. Sarrao, Kashiwaya, Laura H. Greene, Naidyuk, Naidyuk, Nakatsuji, Park, Park, Park, Park, Pham, Rourke, Rourke, Sharvin, Sheet, Thompson, Tsuei, Van Harlingen, Vorontsov, Wan Kyu Park   +28 more
core   +1 more source

Transition Into Clinical Routine and Survival Outcomes of BCL2‐ and BTK Inhibitors: An Analysis of Patient Data From the GCLLSG Registry

European Journal of Haematology, EarlyView.
ABSTRACT Within a dataset of the German CLL Study Group (GCLLSG) registry, 274 patients were allocated to a cohort with venetoclax and 888 to a cohort with BTKi (79 acalabrutinib, 809 ibrutinib), each as first administered targeted substance class within the documented treatment sequence.
Nadine Kutsch, Rudy Ligtvoet, Sandra Robrecht, Hartmut Linde, Thomas Illmer, Steffen Dörfel, Jörg Lipke, Ali Aldaoud, Rudolf Schlag, Jolanta Dengler, Othman Al‐Sawaf, Petra Langerbeins, Paula Cramer, Michael Hallek, Barbara Eichhorst, Kirsten Fischer, Anna Fink   +16 more
wiley   +1 more source

Conformational heterogeneity of the BTK PHTH domain drives multiple regulatory states

eLife
Full-length Bruton’s tyrosine kinase (BTK) has been refractory to structural analysis. The nearest full-length structure of BTK to date consists of the autoinhibited SH3–SH2–kinase core.
David Yin-wei Lin, Lauren E Kueffer, Puneet Juneja, Thomas E Wales, John R Engen, Amy H Andreotti   +5 more
doaj   +1 more source

Crucial role of SLP-76 and ADAP for neutrophil recruitment in mouse kidney ischemia-reperfusion injury. [PDF]

, 2012
Neutrophils trigger inflammation-induced acute kidney injury (AKI), a frequent and potentially lethal occurrence in humans. Molecular mechanisms underlying neutrophil recruitment to sites of inflammation have proved elusive. In this study, we demonstrate
Block, Helena, Herter, Jan, Kliche, Stefanie, Lowell, Clifford, Rossaint, Jan, Stadtmann, Anika, Zarbock, Alexander   +6 more
core