Results 141 to 150 of about 80,266 (330)

A comprehensive analysis of pirtobrutinib in Chinese patients with chronic lymphocytic leukaemia/small lymphocytic lymphoma (CLL/SLL): Results from the phase 3 study BRUIN CLL‐321

British Journal of Haematology, EarlyView.
Summary BRUIN CLL‐321 is the first prospective, randomized study conducted in covalent BTK inhibitor (cBTKi) pretreated chronic lymphocytic leukaemia/small lymphocytic lymphoma (CLL/SLL) patients. In this heavily pretreated population, pirtobrutinib significantly improved progression‐free survival (PFS) compared to investigator's choice (IC) of ...
Shuhua Yi, Jiang Cao, Ru Feng, Keshu Zhou, Lihua Qiu, Fei Li, Hai Yan Yang, Hui Zhou, Wuhan Hui, Jie Cui, He Huang, Jiankun Zhu, Xiuhui Ye, Jeff Sharman, Lugui Qiu   +14 more
wiley   +1 more source

Ismétlés és innováció drámai művekben

Digitális Bölcsészet
Tanulmányunkban egy olyan módszert ismertetünk, amellyel drámai szereplők megszólalásainak hírértéke mérhető össze kvantitatív módon. Innovatívnak tekinthető minden olyan szereplő, aki gyakran dolgoz ki a korábbiaktól eltérő jelentést; fenntartó vagy ...
Botond Szemes, Mihály Nagy
doaj   +1 more source

Probing multiband superconductivity by point-contact spectroscopy

, 2009
Point-contact spectroscopy was originally developed for the determination of the electron-phonon spectral function in normal metals. However, in the past 20 years it has become an important tool in the investigation of superconductors.
Daghero, D., Gonnelli, R. S.
core   +1 more source

Bruton tyrosine kinase (Btk) in neutrophils is indispensable for initiating and maintaining skin inflammation in a model of pemphigoid diseases

British Journal of Pharmacology, EarlyView.
Background and Purpose Bruton tyrosine kinase (Btk) is essential for B cell function. Its role in myeloid cells is less understood. Greater insights into Btk significance in myeloid cells are needed to evaluate its potential as a therapeutic target during the effector phase of antibody‐induced autoimmune diseases, where inhibiting autoantibody ...
Henning Olbrich, Paul Schilf, Sripriya Murthy, Sina Gonther, Mareike Neumann, Christoph M. Hammers, Jasper N. Pruessmann, Christian D. Sadik   +7 more
wiley   +1 more source

Frontline Therapy in Diffuse Large B‐Cell Lymphoma: Evolving Standards, Biological Insights, and Future Directions

European Journal of Haematology, EarlyView.
ABSTRACT Diffuse large B‐cell lymphoma (DLBCL) remains the most common aggressive lymphoma, representing a biologically heterogeneous disease with diverse clinical behaviors. For more than two decades, R‐CHOP has been the cornerstone of frontline treatment, curing approximately two‐thirds of patients.
Mamdouh Skafi, Santino Caserta, Ernesto Vigna, Antonella Bruzzese, Nicola Amodio, Eugenio Lucia, Virginia Olivito, Caterina Labanca, Francesco Mendicino, Maria Eugenia Alvaro, Fortunato Morabito, Enrica Antonia Martino, Massimo Gentile   +12 more
wiley   +1 more source

Distinct Roles for Bruton's Tyrosine Kinase in B Cell Immune Synapse Formation

Frontiers in Immunology, 2018
Bruton's tyrosine kinase (Btk) has a key role in the signaling pathways of receptors essential for the B lymphocyte response. Given its implication in B cell-related immunodeficiencies, leukemias/lymphomas and autoimmunity, Btk is studied intensely and ...
Sara Roman-Garcia, Sara V. Merino-Cortes, Sofia R. Gardeta, Marjolein J. W. de Bruijn, Rudi W. Hendriks, Yolanda R. Carrasco   +5 more
doaj   +1 more source

Experimental evaluation of preprocessing algorithms for constraint satisfaction problems [PDF]

, 1992
This paper presents an experimental evaluation of two orthogonal schemes for preprocessing constraint satisfaction problems (CSPs). The first of these schemes involves a class of local consistency techniques that includes directional arc consistency ...
Dechter, Rina, Meiri, Itay
core  

Superconducting gap parameters of MgB2 obtained on MgB2/Ag and MgB2/In junctions

, 2001
MgB2 superconducting wires with critical temperature Tc approaching 40 K were used for preparation of MgB2/Ag and MgB2/In junctions. The differential conductance vs.
A. Plecenik, Blonder, Blonder, M. Grajcar, Nagamatsu, P. Kúš, Plecenik, Š. Beňačka   +7 more
core   +1 more source

Therapeutic advances in pruritus as a model of personalized medicine

Journal of the European Academy of Dermatology and Venereology, EarlyView.
Recent advances in itch biology reveal that chronic pruritus arises from distinct neuroimmune pathways driven by cytokines, JAK, BTK and GPCRs. Targeted biologics and small molecule inhibitors such as dupilumab, nemolizumab, remibrutinib and JAK inhibitors precisely modulate these pathways, leading to a new era of personalized therapeutics in pruritus.
Kelsey Auyeung, Ramsey Kubofcik, Brian S. Kim   +2 more
wiley   +1 more source

The Btk inhibitor AB‐95‐LH34 potently inhibits atherosclerotic plaque–induced thrombus formation and platelet procoagulant activity [PDF]

, 2022
Christopher W. Smith, Maan H. Harbi, Lourdes Garcia‐Quintanilla, Kieran Rookes, Helena Brown, Natalie S. Poulter, Steve P. Watson, Phillip L.R. Nicolson, Mark R. Thomas   +8 more
openalex   +1 more source