Results 181 to 190 of about 80,266 (330)

Polymethoxylated N‐Carboranyl Isoquinolinones: A New Scaffold for ABCG2 Inhibitors

ChemMedChem, Volume 21, Issue 3, 12 February 2026.
Combinations of a boron‐based clusters (carborane) and polymethoxy group patterns are crucial to overcome ABCG2‐mediated multidrug resistance in cancer cells. (Created in BioRender. Kuhnert, L. (2025) https://BioRender.com/h4cnh5m). ABCG2‐mediated multidrug resistance (MDR) is a major challenge among chemotherapeutic treatments of colon, pancreatic ...
Lydia Kuhnert, Philipp Stockmann, Peter Lönnecke, Mara Anna Wolniewicz, Evamarie Hey‐Hawkins, Walther Honscha   +5 more
wiley   +1 more source

Bruton tyrosine kinase (BTK) may be a potential therapeutic target for interstitial cystitis/bladder pain syndrome [PDF]

, 2022
Guang Wang, Tongxin Yang, Jiongming Li, Ziye Huang, Wenbo Yang, Pei Li, Dalin He   +6 more
openalex   +1 more source

A rationale for blocking thromboinflammation in COVID-19 with Btk inhibitors

Platelets, 2020
Phillip LR. Nicolson, John D. Welsh, Abhishek Chauhan, Mark R. Thomas, Mark L. Kahn, Steve P. Watson   +5 more
doaj   +1 more source

Strategies for Managing Toxicities With High‐Dose Methotrexate in Haematological Malignancies: Lessons From Clinical Cases

Clinical Case Reports, Volume 14, Issue 2, February 2026.
ABSTRACT High‐dose methotrexate (HDMTX) is a key component of induction therapy for a range of cancers, but can lead to serious adverse effects, including acute kidney injury (AKI). We report two cases of HDMTX use in haematological malignancies. Patient 1 was an 8‐year‐old girl with high‐grade NHL.
Vanessa McLelland, Martin Guscott, Matthew R. Wilson   +2 more
wiley   +1 more source

Overcoming challenges in CAR‐T therapy for malignancies: Mechanisms and strategies

Clinical and Translational Discovery, Volume 6, Issue 1, February 2026.
Chimeric antigen receptor T (CAR‐T) cell therapy faces three major challenges: tumour‐intrinsic resistance mechanisms, limitations in CAR‐T cell efficacy and immunosuppressive tumour microenvironment (TME) effects. Emerging strategies address these hurdles through precision targeting enhancement, optimised CAR‐T cell persistence/functionality and TME ...
Yushan Huang, Jun Long, Changpeng Yang, Wang Lu, Husheng Mei, Wenbin Qian, Jing Yang, Aibin Liang   +7 more
wiley   +1 more source

Orbital and eustatic control of basin hydrology during the first stage of the Messinian Salinity Crisis

The Depositional Record, Volume 12, Issue 1, February 2026.
The paleo‐hydrology of the Sorbas Basin (SE Spain) and the wider Mediterranean region during the deposition of the Primary Lower Gypsum (PLG) stage of the Messinian Salinity Crisis, from ~5.97 to ~5.60 Ma, was affected by tectonics, precession‐forced climate oscillations, and eustatic sea‐level change.
Fernando Gázquez, Nicholas P. Evans, Thomas K. Bauska, Harold J. Bradbury, Alexandra V. Turchyn, María del Carmen Barroso, Alexander M. Piotrowski, José María Calaforra, David A. Hodell   +8 more
wiley   +1 more source

Advances in Targeted Therapy: Addressing Resistance to BTK Inhibition in B-Cell Lymphoid Malignancies [PDF]

Andrés Bravo-González, Maryam Alasfour, Deborah Soong, Jose Noy, Georgios Pongas   +4 more
openalex   +1 more source

BTK Inhibitors Differentially Induce Apoptosis but Similarly Suppress Chemotaxis and Lipid Accumulation in Mantle Cell Lymphoma [PDF]

, 2020
Zhuojun Liu, Jia Liu, Tainming Zhang, Lin Li, Shuo Zhang, Hao Jia, Yuanshi Xia, Mingxia Shi, Jing Zhang, Shuhua Yue, Xiaofang Chen, Jian Yu   +11 more
openalex   +1 more source

CRISPR Screens Identify PIK3C2A as a Novel Mediator of EGFR Inhibitor Resistance in Head and Neck Squamous Cell Carcinoma

Head &Neck, Volume 48, Issue 2, Page 486-495, February 2026.
ABSTRACT Background Head and neck squamous cell carcinoma (HNSCC) is a malignancy with poor prognosis and survival. While epidermal growth factor receptor (EGFR) is a known driver of HNSCC, EGFR inhibitors show limited efficacy as monotherapies, suggesting that effective combination therapies are needed.
Jiayu Wang, Megan L. Ludwig, Aditi Kulkarni, Andrew C. Birkeland, Nicole L. Michmerhuizen, Elizabeth Gensterblum‐Miller, Jingyi Zhai, Hui Jiang, Paul Swiecicki, Marisa Buchakjian, Molly Heft Neal, Steven B. Chinn, Matthew E. Spector, J. Chad Brenner   +13 more
wiley   +1 more source

Gene editing of BTK using CRISPR/Cas9 to study drug resistance in acute myeloid leukaemia

, 2019
Melanie Märken
openalex   +1 more source