Results 231 to 240 of about 78,184 (307)

BTK Inhibitor DTRMWXHS-12 [PDF]

, 2020
openaire   +1 more source

Ghrelin Receptor Deletion or Pharmacological Inhibition Improves Muscle Function in Aging Male Mice

Aging Cell, Volume 25, Issue 4, April 2026.
Ghrelin receptor (GHSR‐1a) deletion and pharmacological inverse agonism improved muscle function and restored mitophagy and mitochondrial biogenesis markers in aged male mice. ABSTRACT Sarcopenia is characterized by age‐related declines in muscle strength and mass, along with impaired physical function.
Haiming L. Kerr, Kora Krumm, Nornubari Myree, Artur Rybachok, Elizabeth Dacek, Brynn Irwin, Siyi Jiang, Lucas Caeiro, Barbara Anderson, Theresa Li, Amanda Chen, Ross Burnside, Jessica Li, Morgan Sydor, David J. Marcinek, Gennifer E. Merrihew, James W. MacDonald, Theo K. Bammler, Michael J. MacCoss, Jose M. Garcia   +19 more
wiley   +1 more source

B cell receptor signaling in autoimmune rheumatic diseases: regulatory mechanisms and therapeutic targeting. [PDF]

Front Immunol
Zhu Y, Gao L, Han Y, Liu F, Xie X, Dai X, Wang Y, Guo Y, Luo C, Chen Y, Huang P, Du Z.   +11 more
europepmc   +1 more source

Splenic B‐Cell Lymphoma/Leukemia With Prominent Nucleoli Presenting With Characteristic Peripheral Blood and Bone Marrow Findings

eJHaem, Volume 7, Issue 2, April 2026.
Koie Son, Yoshimitsu Shimomura, Daisuke Yamashita, Tadakazu Kondo   +3 more
wiley   +1 more source

Attempts to Achieve Targeted Covalent Inhibition of Hsp90β

Chemical Biology &Drug Design, Volume 107, Issue 4, April 2026.
Electrophilic warheads were incorporated into Hsp90β‐selective inhibitors to covalently modify Lys58, which occupies the solvent‐exposed region of the binding pocket. Although many inhibitors display nanomolar affinity towards Hsp90β over a 24‐h period, analyses to determine covalent bond formation with this residue were inconclusive.
Terin D'Amico, Tyelor S. Reynolds, Michael A. Serwetnyk, Brian S. J. Blagg   +3 more
wiley   +1 more source

Chemotherapy‐Sparing Strategies in Follicular Lymphoma: Emerging Targeted and Immune‐Based Approaches

European Journal of Haematology, Volume 116, Issue 4, Page 368-379, April 2026.
ABSTRACT Follicular lymphoma (FL), traditionally considered an indolent yet incurable malignancy, is experiencing a substantial evolution in its therapeutic landscape with the emergence of chemo‐free treatment strategies. These novel approaches challenge conventional chemotherapy‐based paradigms and offer promising alternatives for both newly diagnosed
Enrica Antonia Martino, Santino Caserta, Mamdouh Skafi, Maria Eugenia Alvaro, Antonella Bruzzese, Nicola Amodio, Eugenio Lucia, Virginia Olivito, Caterina Labanca, Francesco Mendicino, Ernesto Vigna, Fortunato Morabito, Massimo Gentile   +12 more
wiley   +1 more source

Latest advances in frontline CLL treatment from the 2025 ASH congress. [PDF]

Ann Hematol
Visentin A.
europepmc   +1 more source

BTK inhibitor TG-1701 [PDF]

, 2020
openaire   +1 more source

Translational immunothrombosis in autoimmune Heparin-Induced thrombocytopenia: targeting the FcγRIIa-Syk-BTK and complement pathways. [PDF]

Clin Exp Med
Ahmadinia M, Askarzade A, Afsharara H, Gholizadeh Niari B, Jamali F, Farasatinasab M.   +5 more
europepmc   +1 more source

Cutaneous Adverse Effects in Patients Treated with BTK Inhibitors. [PDF]

Cancers (Basel)
Robak E, Robak T.
europepmc   +1 more source