Results 221 to 230 of about 78,184 (307)

Post‐translational Modifications in Proteins: Prediction Methods, Biological Functions, and Diseases

MedComm, Volume 7, Issue 4, April 2026.
Posttranslational modifications (PTMs) serve as rapid and reversible molecular switches that reshape protein activity, stability, and interactomes, thereby governing virtually all physiological cues ranging from signal transduction to epigenetic memory. Mass spectrometry‐based proteomics has substantially expanded our understanding of PTM emergence and
Shuning Zhang, Jingmin Li, Meihuan Chen, Hailong Huang   +3 more
wiley   +1 more source

Corrigendum to "Tumor-homing exosomes enable targeted delivery of siRNA and isoimperatorin for overcoming BTK inhibitor resistance in DLBCL" [Mater. Today Bio (35) 102267]. [PDF]

Mater Today Bio
Sun R, Yang Y, Zhang B, Chen J, Wang Y, Jiang Z, Zhang L, Ashrafizadeh M, Sethi G, Shen J, Chi Z.   +10 more
europepmc   +1 more source

Disarming the Hsp70–Bim Alliance: Small‐Molecule and Peptidic Disruptors of a Chaperone‐Apoptotic Switch in Cancer

ChemistryOpen, Volume 15, Issue 4, April 2026.
Targeting a nucleotide‐sensitive groove on Hsp70 that binds the Bim BH3 helix, we integrate structures, biophysics, and SAR from peptides, fragments, and phenalene‐dicarbonitrile “wedges.” These disrupt the Hsp70–Bim complex with sub‐µM cellular engagement and in vivo activity while sparing Hsp90/mortalin.
Emadeldin M. Kamel, Mohammed Al‐zharani, Lina M. Alneghery, Noha A. Ahmed, Faris F. Aba Alkhayl, Al Mokhtar Lamsabhi   +5 more
wiley   +1 more source

Tunable Aromatic Sulfoxides and Sulfones as Cysteine-Targeting Warheads: Exploring the Structure-Reactivity Relationship. [PDF]

J Med Chem
Nyström H, Valaka AP, Kalesse HA, Håversen L, Olsson T, Gunnarsson A, Schweikart F, Borén J, Grøtli M.   +8 more
europepmc   +1 more source

Phytochemical‐Based Strategies for Lung Cancer: Clinical Insights Into Pleiotropic Molecular Signaling and Therapeutic Roles

Phytotherapy Research, Volume 40, Issue 4, Page 2003-2024, April 2026.
Lung cancer (LC) remains the leading cause of global cancer‐related death. Phytochemicals from medicinal plants are increasingly being considered as potential LC treatment agents due to their multi‐targeted action, safety, and accessibility. These have anticancer properties by regulating key molecular signaling pathways.
Md. Rezaul Islam, Abdur Rauf, Happy Akter, Md. Ibrahim Khalil Al‐Imran, Md. Naeem Hossain Fakir, Gazi Kaifeara Thufa, Umme Habiba, Karjin Nahar Riya, Md. Mahfuzur Rahman, Md Sadique Hussain, Hanan A. Ogaly, Abdullah S. M. Aljohani, Waleed Al Abdulmonem, Dorota Formanowicz, Marcello Iriti   +14 more
wiley   +1 more source

Considerations for establishing occupational exposure limits for small molecule kinase inhibitors in drug development. [PDF]

Front Toxicol
Nicholas T, Morinello E, Moudgal C, Beaulieu A, Graham J.   +4 more
europepmc   +1 more source

Biodegradable Mg Alloys: Enhancing Anti‐tumor Immunity in Cancer Therapy

Rare Metals, Volume 45, Issue 4, April 2026.
ABSTRACT Magnesium (Mg) alloys, as biodegradable metallic materials with excellent biocompatibility and mechanical properties, demonstrate significant advantages. In the field of immunotherapy, they present a promising potential option for enhancing therapeutic outcomes and hold broad prospects for application.
Can Feng, Ning Liang, Pingping Hu, Yingying Zhang, Jun Wang, Zhong Lu, Kai Guan, Guodong Deng, Jiandong Zhang   +8 more
wiley   +1 more source

Photothermal Resilience of Biopolymer-Based Btk Microcapsules: Implications for Sustainable Pest Control. [PDF]

ACS Omega
Suresha GV, Neethu Roy D, Duraimurugan P, Chandrika KSVP.   +3 more
europepmc   +1 more source

Mono(2‐Ethylhexyl) Phthalate Induces Inflammatory and Angiogenic Alterations Mediated by the PI3K/AKT Pathway in HTR‐8/SVneo Trophoblastic Cells

Environmental Toxicology, Volume 41, Issue 4, Page 209-222, April 2026.
ABSTRACT Exposure to mono(2‐ethylhexyl) phthalate (MEHP) during pregnancy has been associated with adverse pregnancy and birth outcomes characterized by extravillous trophoblast (EVT) abnormal function. Previous reports have suggested that MEHP can activate the PI3K/AKT pathway in EVT cells, a pathway known to regulate inflammation and angiogenesis in ...
Luis Daniel Martínez‐Razo, Ericka Karol Pamela Almeida‐Aguirre, Mariana Bobadilla‐Bravo, Ismael Mancilla‐Herrera, Alejandra Martínez‐Ibarra, Marco Cerbón   +5 more
wiley   +1 more source

Richter-like transformation of CLL/SLL after a temporary hold of ibrutinib: A case report. [PDF]

Leuk Res Rep
Chiang TL, Frater J, Cashen A.
europepmc   +1 more source